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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Alpha-1A adrenergic receptor
Species	Bos taurus (Bovine)
Gene	ADRA1A
Synonym	Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
UniProt	P18130
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4892
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	1',2',3',6'-Tetrahydro-[2,4']bipyridinyl
Molecular formula	C10H12N2
IUPAC name	2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine
Molecular weight	160.22
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	0.6
Synonyms	DTXSID50569450 BDBM50026630 ZINC19811349 1'',2'',3'',6''-Tetrahydro-[2,4'']bipyridinyl CTK4J2646 2,4'-Bipyridine, 1',2',3',6'-tetrahydro- 50461-51-3 IVRPDZRVHKIBBG-UHFFFAOYSA-N 1',2',3',6'-tetrahydro-2,4'-bipyridine D08UDY 2-(1,2,3,6-tetrahydropyridin-4-yl)pyridine AKOS000205268 SCHEMBL169400 CHEMBL278934 [ Show all ]
Inchi Key	IVRPDZRVHKIBBG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H12N2/c1-2-6-12-10(3-1)9-4-7-11-8-5-9/h1-4,6,11H,5,7-8H2
PubChem CID	15166842
ChEMBL	CHEMBL278934
IUPHAR	N/A
BindingDB	50026630
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4000.0 nM	PMID6088770	BindingDB,ChEMBL

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