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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Adenosine receptor A2a
Species	Rattus norvegicus (Rat)
Gene	Adora2a
Synonym	A2-AR A2A receptor adenosine receptor A2a RDC8
Disease	N/A for non-human GPCRs
Length	410
Amino acid sequence	MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
UniProt	P30543
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL302
IUPHAR	19
DrugBank	N/A

Ligand

Name	8-Phenylxanthine
Molecular formula	C11H8N4O2
IUPAC name	8-phenyl-3,7-dihydropurine-2,6-dione
Molecular weight	228.211
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	0.9
Synonyms	1H-Purine-2,6-dione, 3,9-dihydro-8-phenyl- ZINC13472986 D0L8DZ 0S2BVG6C31 UNII-0S2BVG6C31 2879-14-3 CHEMBL285191 8-Phenyl-1H-purine-2,6(3H,7H)-dione DTXSID50485464 1H-Purine-2,6-dione, 3,7-dihydro-8-phenyl- BDBM50042214 Xanthine, 8-phenyl- 3,7-Dihydro-8-phenyl-1H-purine-2,6-dione CTK0J1822 8-Phenyl-3,7-dihydro-purine-2,6-dione SCHEMBL378879 [ Show all ]
Inchi Key	ACCCXSZCOGNLFL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H8N4O2/c16-10-7-9(14-11(17)15-10)13-8(12-7)6-4-2-1-3-5-6/h1-5H,(H3,12,13,14,15,16,17)
PubChem CID	12295530
ChEMBL	CHEMBL285191
IUPHAR	N/A
BindingDB	50042214
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	21000.0 nM	PMID11906291	BindingDB,ChEMBL

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