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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CID 62706851
Molecular formula	C22H26N4O4
IUPAC name	methyl 2-[4-[3-[(3-oxo-1-benzofuran-6-yl)amino]propyl]piperidin-1-yl]pyrimidine-5-carboxylate
Molecular weight	410.474
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	3.2
Synonyms	N/A
Inchi Key	ISAUICAMOUVWRT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N4O4/c1-29-21(28)16-12-24-22(25-13-16)26-9-6-15(7-10-26)3-2-8-23-17-4-5-18-19(27)14-30-20(18)11-17/h4-5,11-13,15,23H,2-3,6-10,14H2,1H3
PubChem CID	62706851
ChEMBL	CHEMBL2058668
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	149.0 nM	PMID22765901	ChEMBL
Emax	85.0 %	PMID22765901	ChEMBL

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