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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 4
Species	Homo sapiens (Human)
Gene	P2RY4
Synonym	UNR pyrimidinoceptor pyrimidinergic receptor P2Y P2Y4R P2Y4 receptor P2Y4 P2Y purinoceptor 4 P2Y ATP receptor 4 P2P NRU uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	365
Amino acid sequence	MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
UniProt	P51582
Protein Data Bank	N/A
GPCR-HGmod model	P51582
3D structure model	This predicted structure model is from GPCR-EXP P51582.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2123
IUPHAR	325
DrugBank	N/A

Ligand

Name	CHEMBL500840
Molecular formula	C16H28N2O22P4
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2S,3R,4R,5S)-5-ethyl-3,4,5-trihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
Molecular weight	724.287
Hydrogen bond acceptor	22
Hydrogen bond donor	10
XlogP	-8.1
Synonyms	BDBM50270544 Uridine-5''-fructose-6''-tetraphosphate
Inchi Key	IRHOAYPWMKMNPQ-MLTZJJJHSA-N
Inchi ID	InChI=1S/C16H28N2O22P4/c1-2-16(25)13(23)11(21)8(37-16)6-35-42(28,29)39-44(32,33)40-43(30,31)38-41(26,27)34-5-7-10(20)12(22)14(36-7)18-4-3-9(19)17-15(18)24/h3-4,7-8,10-14,20-23,25H,2,5-6H2,1H3,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,17,19,24)/t7-,8+,10-,11+,12-,13-,14-,16+/m1/s1
PubChem CID	44585517
ChEMBL	CHEMBL500840
IUPHAR	N/A
BindingDB	50270544
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6300.0 nM	PMID18514530	BindingDB,ChEMBL

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