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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	CHEMBL1802431
Molecular formula	C41H55N11O8
IUPAC name	(2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-aminopropanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanamide
Molecular weight	829.96
Hydrogen bond acceptor	10
Hydrogen bond donor	11
XlogP	-0.8
Synonyms	BDBM50347831
Inchi Key	IQZAMBIMRXYPCR-YXKTVTGNSA-N
Inchi ID	InChI=1S/C41H55N11O8/c1-25(42)36(56)47-23-34(54)48-31(21-27-14-7-3-8-15-27)38(58)52-33(24-53)40(60)51-32(22-28-16-9-4-10-17-28)39(59)49-29(18-11-19-46-41(44)45)37(57)50-30(35(43)55)20-26-12-5-2-6-13-26/h2-10,12-17,25,29-33,53H,11,18-24,42H2,1H3,(H2,43,55)(H,47,56)(H,48,54)(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H4,44,45,46)/t25-,29-,30-,31-,32-,33-/m0/s1
PubChem CID	56673335
ChEMBL	CHEMBL1802431
IUPHAR	N/A
BindingDB	50347831
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3350.0 nM	PMID21623631	BindingDB,ChEMBL

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