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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL340989
Molecular formulaC27H27N5O2
IUPAC nameN-[2-[4-[cyano(pyridin-4-yl)methyl]piperazin-1-yl]-2-oxoethyl]-2,2-diphenylacetamide
Molecular weight453.546
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.6
SynonymsSCHEMBL9852940
BDBM50003530
N-{2-[4-(Cyano-pyridin-4-yl-methyl)-piperazin-1-yl]-2-oxo-ethyl}-2,2-diphenyl-acetamide
Inchi KeyIPOCEWGZFJGJBN-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H27N5O2/c28-19-24(21-11-13-29-14-12-21)31-15-17-32(18-16-31)25(33)20-30-27(34)26(22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14,24,26H,15-18,20H2,(H,30,34)
PubChem CID9981360
ChEMBLCHEMBL340989
IUPHARN/A
BindingDB50003530
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50680.0 nMPMID1433215BindingDB,ChEMBL

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