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GLASS

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GPCR

Name	Neuropeptide S receptor
Species	Homo sapiens (Human)
Gene	NPSR1
Synonym	G-protein coupled receptor for asthma susceptibility vasopressin receptor-related receptor 1 G protein-coupled receptor 154 PGR14 NPS receptor G-protein coupled receptor 154 GPR154 G-protein coupled receptor PGR14 VRR1 [ Show all ]
Disease	Neurological disease
Length	371
Amino acid sequence	MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
UniProt	Q6W5P4
Protein Data Bank	N/A
GPCR-HGmod model	Q6W5P4
3D structure model	This predicted structure model is from GPCR-EXP Q6W5P4.
BioLiP	N/A
Therapeutic Target Database	T20958
ChEMBL	CHEMBL5162
IUPHAR	302
DrugBank	BE0000948

Ligand

Name	(+/-)-Epinephrine hydrochloride
Molecular formula	C9H14ClNO3
IUPAC name	[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylazanium;chloride
Molecular weight	219.665
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	None
Synonyms	4-[1-HYDROXY-2-(METHYLAMINO)ETHYL]-1,2-BENZENEDIOL HYDROCHLORIDE EINECS 206-346-0 VC30860 (+-)-Adrenaline hydrochloride BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((METHYLAMINO)METHYL)-, HYDROCHLORIDE, (+)- KS-000017ZU [2-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-ethyl]-methyl-azanium chloride 1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, hydrochloride CTK8F1536 MCULE-9233286495 A821532 Epinephrine dl- hydrochloride [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylammonium chloride Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (+-)- LS-42885 1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochloride d-Epinephrine hydrochloride MolPort-000-807-126 (+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol hydrochloride AC1L1T5P J-018951 [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylazanium chloride (1)-4-(1-Hydroxy-2-(methylamino)ethyl)pyrocatechol hydrochloride LS-42886 [ Show all ]
Inchi Key	ATADHKWKHYVBTJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
PubChem CID	9489
ChEMBL	CHEMBL1255663
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Potency	3162.3 nM	PubChem BioAssay data set	ChEMBL

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