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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCID 15005355
Molecular formulaC32H29ClN4O3S
IUPAC nameethyl 4-(2-chlorophenyl)-2-[4-(2,4-dimethyl-1,3-thiazol-5-yl)phenyl]-6-methyl-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate
Molecular weight585.119
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP6.5
SynonymsN/A
Inchi KeyIEHJPYAALFZMBX-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H29ClN4O3S/c1-5-40-32(39)28-27(23-10-6-7-11-24(23)33)26(31(38)37-25-12-8-9-17-34-25)18(2)36-29(28)21-13-15-22(16-14-21)30-19(3)35-20(4)41-30/h6-17,27,36H,5H2,1-4H3,(H,34,37,38)
PubChem CID15005355
ChEMBLCHEMBL323429
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
ED507.4 mg.kg-1PMID1507200ChEMBL

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