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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Mus musculus (Mouse)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P12657
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3733
IUPHAR	13
DrugBank	N/A

Ligand

Name	158142-45-1
Molecular formula	C6H10N2O2
IUPAC name	methyl 1,4,5,6-tetrahydropyrimidine-5-carboxylate
Molecular weight	142.158
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	-0.9
Synonyms	SCHEMBL8306627 CHEMBL1189286 L008012 AKOS006358308 CHEMBL538467 1,4,5,6-Tetrahydro-5-pyrimidinecarboxylic acid methyl ester Methyl 1,4,5,6-tetrahydropyrimidine-5-carboxylate 5-pyrimidinecarboxylic acid,1,4,5,6-tetrahydro-,methyl ester BDBM50039839 KB-198515 1,4,5,6-Tetrahydro-pyrimidine-5-carboxylic acid methyl ester; hydrochloride [ Show all ]
Inchi Key	ASEICNBZJHLFCN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H10N2O2/c1-10-6(9)5-2-7-4-8-3-5/h4-5H,2-3H2,1H3,(H,7,8)
PubChem CID	10197743
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50039839
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	200000.0 nM	PMID9111297	BindingDB
Ki	24.0 nM	PMID9111297	BindingDB
Ki	27.0 nM	PMID9111297	BindingDB
Ki	359.0 nM	PMID9111297	BindingDB

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