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Name | D(1A) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD1 |
Synonym | D1 receptor D1A DADR Gpcr15 dopamine D1 receptor [ Show all ] |
Disease | Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder [ Show all ] |
Length | 446 |
Amino acid sequence | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT |
UniProt | P21728 |
Protein Data Bank | N/A |
GPCR-HGmod model | P21728 |
3D structure model | This predicted structure model is from GPCR-EXP P21728. |
BioLiP | N/A |
Therapeutic Target Database | T22118 |
ChEMBL | CHEMBL2056 |
IUPHAR | 214 |
DrugBank | BE0000020 |
Name | 4-Diphenylacetoxy-1,1-dimethylpiperidinium |
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Molecular formula | C21H26NO2+ |
IUPAC name | (1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate |
Molecular weight | 324.444 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 4.0 |
Synonyms | AC1Q60WY CHEMBL76897 LS-177624 NCGC00163244-01 4-Damp methobromide [ Show all ] |
Inchi Key | HYJRTXSYDAFGJK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1 |
PubChem CID | 1734 |
ChEMBL | CHEMBL168067 |
IUPHAR | 307 |
BindingDB | 50176065 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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Potency | 259.3 nM | PubChem BioAssay data set | ChEMBL |
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