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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh1
Synonym	H1 receptor H1R HH1R Hisr
Disease	N/A for non-human GPCRs
Length	486
Amino acid sequence	MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
UniProt	P31390
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4701
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	BURIMAMIDE
Molecular formula	C9H16N4S
IUPAC name	1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea
Molecular weight	212.315
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.4
Synonyms	LS-187654 TN5A4OD2TV NCGC00167790-01 1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea HXRBAVXGYZUSED-UHFFFAOYSA-N SCHEMBL7860369 AC1MHUYH N-(4-imidazol-4-ylbutyl)-N'-methylthiourea UNII-TN5A4OD2TV C07448 PDSP1_001097 CHEMBL12160 LS-187038 Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- BDBM22888 N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea ZINC13831238 1-[4-(1H-imidazol-5-yl)butyl]-3-methyl-thiourea CHEBI:3221 DTXSID00188519 PDSP2_001081 34970-69-9 [ Show all ]
Inchi Key	HXRBAVXGYZUSED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H16N4S/c1-10-9(14)12-5-3-2-4-8-6-11-7-13-8/h6-7H,2-5H2,1H3,(H,11,13)(H2,10,12,14)
PubChem CID	3032915
ChEMBL	CHEMBL12160
IUPHAR	N/A
BindingDB	22888
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID282646	BindingDB

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