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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	UNII-8L7H229K4I
Molecular formula	C14H21NO
IUPAC name	3-[(3R)-1-propylpiperidin-3-yl]phenol
Molecular weight	219.328
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.0
Synonyms	SCHEMBL8354256 3-(1-Propyl-piperidin-3-yl)-phenol CCG-205066 NCGC00015776-02 ZINC393 cid_202478 PDSP2_000624 R-3-(3-Hydroxyphenyl)-N-propylpiperidine HCl (r)-3-(3-hydroxyphenyl)-N-propylpiperidine AC1L48LV Lopac0_000986 SR-01000075393-11 3-[(3R)-1-propylpiperidin-3-yl]phenol NCGC00162308-02 85976-54-1 Lopac-P-102 Preclamol, (R)- R-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride 3-((R)-1-Propyl-piperidin-3-yl)-phenol BDBM50010618 NCGC00015776-01 3PPP,(-) CHEMBL7393 PDSP1_000628 R(+)-3-PPP (+)-3-(1-Propyl-piperidin-3-yl)-phenol 8L7H229K4I Lopac-P-103 [ Show all ]
Inchi Key	HTSNFXAICLXZMA-ZDUSSCGKSA-N
Inchi ID	InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m0/s1
PubChem CID	202478
ChEMBL	CHEMBL7393
IUPHAR	N/A
BindingDB	50010618
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92470.0 nM	N/A	BindingDB

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