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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesMus musculus (Mouse)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length513
Amino acid sequenceMAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP32240
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2489
IUPHAR343
DrugBankN/A

Ligand

NameCHEMBL182555
Molecular formulaC22H23NO4
IUPAC name2-[1-(4-butoxybenzoyl)-2-methylindol-4-yl]acetic acid
Molecular weight365.429
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.6
Synonyms[1-(4-Butoxy-benzoyl)-2-methyl-1H-indol-4-yl]-acetic acid
BDBM50152507
SCHEMBL5850964
Inchi KeyHSIPEEIFZHZSBZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H23NO4/c1-3-4-12-27-18-10-8-16(9-11-18)22(26)23-15(2)13-19-17(14-21(24)25)6-5-7-20(19)23/h5-11,13H,3-4,12,14H2,1-2H3,(H,24,25)
PubChem CID10361472
ChEMBLCHEMBL182555
IUPHARN/A
BindingDB50152507
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID15341946BindingDB,ChEMBL

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