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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 1
Species	Homo sapiens (Human)
Gene	GALR1
Synonym	GAL1-R GALNR GALNR1 GALR-1 GAL1 receptor
Disease	Epileptic seizures
Length	349
Amino acid sequence	MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProt	P47211
Protein Data Bank	N/A
GPCR-HGmod model	P47211
3D structure model	This predicted structure model is from GPCR-EXP P47211.
BioLiP	N/A
Therapeutic Target Database	T78581
ChEMBL	CHEMBL4894
IUPHAR	243
DrugBank	N/A

Ligand

Name	CHEMBL1922009
Molecular formula	C23H25F2N5O2
IUPAC name	4-N-[3-(difluoromethoxy)phenyl]-2-N-(4-methoxyphenyl)-6-piperidin-1-ylpyrimidine-2,4-diamine
Molecular weight	441.483
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	6.1
Synonyms	SCHEMBL10143429 BDBM50358679
Inchi Key	HSGACOSXIJOBFW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25F2N5O2/c1-31-18-10-8-16(9-11-18)27-23-28-20(15-21(29-23)30-12-3-2-4-13-30)26-17-6-5-7-19(14-17)32-22(24)25/h5-11,14-15,22H,2-4,12-13H2,1H3,(H2,26,27,28,29)
PubChem CID	57394239
ChEMBL	CHEMBL1922009
IUPHAR	N/A
BindingDB	50358679
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	60.0 %	PMID22018787	ChEMBL

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