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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-1 angiotensin II receptor
Species	Oryctolagus cuniculus (Rabbit)
Gene	AGTR1
Synonym	Angiotensin II type-1 receptor AT1
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
UniProt	P34976
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3948
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1951138
Molecular formula	C30H35N7O2S
IUPAC name	2-butyl-6-methyl-5-(3-oxo-3-thiomorpholin-4-ylpropyl)-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-4-one
Molecular weight	557.717
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.7
Synonyms	SCHEMBL7811655 BDBM50364568
Inchi Key	AQXMWZFBENRRMU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H35N7O2S/c1-3-4-9-27-31-21(2)24(14-15-28(38)36-16-18-40-19-17-36)30(39)37(27)20-22-10-12-23(13-11-22)25-7-5-6-8-26(25)29-32-34-35-33-29/h5-8,10-13H,3-4,9,14-20H2,1-2H3,(H,32,33,34,35)
PubChem CID	53657506
ChEMBL	CHEMBL1951138
IUPHAR	N/A
BindingDB	50364568
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.06 nM	PMID22264484	BindingDB,ChEMBL

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