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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Oxoeicosanoid receptor 1
Species	Homo sapiens (Human)
Gene	OXER1
Synonym	R527 oxoeicosanoid (OXE) receptor 1 OXE receptor hGPCR48 GPR170 G-protein coupled receptor TG1019 G-protein coupled receptor R527 G-protein coupled receptor 170 5-oxo-ETE receptor 5-oxo-ETE G-protein coupled receptor TG1019 [ Show all ]
Disease	N/A
Length	423
Amino acid sequence	MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
UniProt	Q8TDS5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628461
IUPHAR	271
DrugBank	N/A

Ligand

Name	Dihomo-gamma-linolenic acid
Molecular formula	C20H34O2
IUPAC name	(8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
Molecular weight	306.49
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	7.2
Synonyms	all cis-8,11,14-Icosatrienoic Acid Bishomo-gamma-linolenate C20:3n-6,9,12 cis-8,11,14-Eicosatrienoic Acid DB00154 Dihomo-gamma-linolenic acid (DGLA; cis-20:3n-6) (8Z,11Z,14Z)-Icosatrienoic acid FA(20:3(8Z,11Z,14Z)) .gamma.-Homolinolenic acid HMS3402A08 8,11,14-Eicosatrienoate LMFA01030158 8,11-14-Eicosatrienoic acid, (Z,Z,Z)- SR-01000946659 Tona-lean 1000 CLA (Action Labs) all-cis-8,11,14-icosatrienoic acid BRD-K20152659-001-02-0 Cis-8,11,14-Eicosatrienoicacid Dibromo-gamma-linolenic acid DS107 (Z,Z,Z)-8,11,14-Icosatrienoate gamma-Homolinolenic acid 20:3n-6 Homo-gamma-linolenate 8,11,14-Eicosatrienoic acid, (8Z,11Z,14Z)-(9CI) NCGC00161350-01 8Z,11Z,14Z-eicosatrienoate AKOS027320400 all-cis-icosa-8,11,14-trienoic acid C03242 cis,cis,cis-8,11,14-Eicosatrienoic acid CS-0017463 Dihomo-gamma-linolenate (8E,11E,14E)-8,11,14-Icosatrienoic acid Eicosatrienoate (Z,Z,Z)-icosatri-8,11,14-enoate HMS1791A08 8,11,14-all-cis-Eicosatrienoate HY-A0143 8,11,14-Icosatrienoate Ro 12-1989 SR-01000946659-1 all-cis-8,11,14-Eicosatrienoate Bishomo-gamma-linolenic acid CCRIS 7669 cis-8,11,14-Eicosatrienoic acid, >=99% DGLA Dihomolinolenate (Z,Z,Z)-8,11,14-Eicosatrienoate FC398RK06S 1783-84-2 HMS3649H11 8,11,14-Eicosatrienoic acid MFCD00065721 8c,11c,14c-eicosatrienoic acid UNII-FC398RK06S all-cis-eicosa-8,11,14-trienoic acid BSPBio_001286 CHEMBL465183 cis-8,cis-11,cis-14-Eicosatrienoate dihomo -gamma-linolenic acid E0640 (Z,Z,Z)-8,11,14-Icosatrienoic acid GTPL9775 Homo-gamma-linolenic acid 8,11,14-Eicosatrienoic acid, (Z,Z,Z)- (8CI) NCGC00161350-02 8Z,11Z,14Z-eicosatrienoic acid all cis-8,11,14-Eicosatrienoic Acid BDBM50269534 C20:3, n-6,9,12 all-cis cis-8,11,14-Eicosatrienoate D0O1TC (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid EINECS 217-233-0 (Z,Z,Z)-Icosatri-8,11,14-enoic acid HMS1989A08 8,11,14-all-cis-Eicosatrienoic acid IDI1_033756 8,11,14-Icosatrienoic acid SCHEMBL842729 Star GLA (GNC) all-cis-8,11,14-Eicosatrienoic acid BML3-B11 CHEBI:53486 cis-8,11,14-Eicosatrienoic acid, analytical standard di-homo gamma-linolenic acid diroleuton (Z,Z,Z)-8,11,14-Eicosatrienoic acid gamma-Homolinolenate 20:3, n-6,9,12 all-cis HOBAELRKJCKHQD-QNEBEIHSSA-N 8,11,14-Eicosatrienoic acid, (8Z,11Z,14Z)- (9CI) MolPort-003-933-184 8c,11c,14c-Eicosatriensaeure ZINC4521470 all-cis-Eicosa-8,11,14-triensaeure C 20:3 n-6 cis,cis,cis-8,11,14-Eicosatrienoate cis-8,cis-11,cis-14-Eicosatrienoic acid Dihomo-.gamma.-linolenic acid eicosa-8Z,11Z,14Z-trienoic acid (Z,Z,Z)-8,11,14-Icosatrienoicacid HMS1361A08 8, 11, 14-eicosatrienoic acid Homo-gamma-linolensaeure 8,11,14-Eicosatrienoic acid, (Z,Z,Z)-(8CI) NCGC00161350-03 AC1NQX97 [ Show all ]
Inchi Key	HOBAELRKJCKHQD-QNEBEIHSSA-N
Inchi ID	InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
PubChem CID	5280581
ChEMBL	CHEMBL465183
IUPHAR	N/A
BindingDB	50269534
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2000.0 nM	PMID24351031	BindingDB,ChEMBL
Ki	3700.0 nM	PMID12065583	BindingDB

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