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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	(-)-Quinpirole hydrochloride
Molecular formula	C13H22ClN3
IUPAC name	(4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline;hydrochloride
Molecular weight	255.79
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	None
Synonyms	trans-( C)-(4aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline monohydrochloride (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride AKOS024456359 CHEMBL1256574 DTXSID8045519 LY-171555 NCGC00261675-01 SR-01000075397 1H-Pyrazolo(3,4-g)quinolone, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, monohydrochloride,(4aR-trans)- API0008813 D00YAS HY-B1752A MLS002222194 QUINPIROLE HYDROCHLORIDE SR-01000597925-1 (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline hydrochloride 85798-08-9 CCG-222294 DSSTox_GSID_45519 LY 171555 NCGC00016954-05 SCHEMBL121129 Tox21_110707_1 UNII-T6I2W5V2K1 ( C)-Quinpirole monohydrochloride (?)-Quinpirole hydrochloride AKOS030530543 CS-0013777 EU-0100990 LY171555 Q-102 SR-01000075397-1 (-)-Quinpirole hydrochloride, >=98% (HPLC), solid 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline C13H21N3.HCl D05682 LP00990 MolPort-003-666-734 Quinpirole hydrochloride (USAN) T6I2W5V2K1 (4AR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline hydrochloride AC1L1IZP DSSTox_RID_80926 LY-171,555 NCGC00016954-10 SMR000326933 Tox21_500990 (-)-(4aR,8aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo(3,4-g)quinoline monohydrochloride 1H-Pyrazolo(3,4-g)quinoline, 4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, monohydrochloride, (4aR-trans)- AOB5029 CTK8F1419 HMS1571K08 MLS000860075 Quinpirole HCl SR-01000597925 (-)quinpi-role hydrochloride 85760-74-3 CAS-85798-08-9 DSSTox_CID_25519 LS-129351 MolPort-003-959-422 Quinpirole hydrochloride [USAN] Tox21_110707 [ Show all ]
Inchi Key	HJHVRVJTYPKTHX-HTMVYDOJSA-N
Inchi ID	InChI=1S/C13H21N3.ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;/h9-10,13H,2-8H2,1H3,(H,14,15);1H/t10-,13-;/m1./s1
PubChem CID	55397
ChEMBL	CHEMBL1256574
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	24.42 nM	PubChem BioAssay data set	ChEMBL

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