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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000586692
Molecular formula	C19H16N2O6S
IUPAC name	(5Z)-3-(1,3-benzodioxol-5-yl)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one
Molecular weight	400.405
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	3.4
Synonyms	cid_1258954 SR-01000537905 (5Z)-3-(1,3-benzodioxol-5-yl)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-imino-4-thiazolidinone AC1LO7YQ MCULE-5910288962 STK767738 MolPort-019-782-926 (5Z)-3-(1,3-benzodioxol-5-yl)-5-(4-hydroxy-3,5-dimethoxybenzylidene)-2-imino-1,3-thiazolidin-4-one HMS2613K23 SR-01000537905-1 3-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methyle ne]-2-imino-1,3-thiazolidin-4-one AKOS001728239 ZINC4577804 (5Z)-2-azanylidene-3-(1,3-benzodioxol-5-yl)-5-[(3,5-dimethoxy-4-oxidanyl-phenyl)methylidene]-1,3-thiazolidin-4-one CHEMBL1428770 SMR000208071 (5Z)-3-(1,3-benzodioxol-5-yl)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one HMS639N13 ST085545 A2765/0117248 BDBM50192 MolPort-002-713-961 (5Z)-3-(1,3-benzodioxol-5-yl)-5-(4-hydroxy-3,5-dimethoxy-benzylidene)-2-imino-thiazolidin-4-one [ Show all ]
Inchi Key	HIWBRHNPKYABSM-CQRAXGMXSA-N
Inchi ID	InChI=1S/C19H16N2O6S/c1-24-14-5-10(6-15(25-2)17(14)22)7-16-18(23)21(19(20)28-16)11-3-4-12-13(8-11)27-9-26-12/h3-8,20,22H,9H2,1-2H3/b16-7-,20-19?
PubChem CID	1258954
ChEMBL	CHEMBL1428770
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	5623.4 nM	PubChem BioAssay data set	ChEMBL

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