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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1771099
Molecular formula	C24H28ClFN4O2
IUPAC name	4-[[2-[[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]methyl]cyclopropyl]methoxy]-N-cyclopropyl-2-fluorobenzamide
Molecular weight	458.962
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.8
Synonyms	(rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methyl)cyclopropyl)methoxy)-N-cyclopropyl-2-fluorobenzamide BDBM50342698 SCHEMBL1186773 (rac)-trans-4-((2-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methyl)cyclopropyl)methoxy)-N-cyclopropyl-2-fluorobenzamide
Inchi Key	HGXIXRDSWVTXLX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
PubChem CID	54581962
ChEMBL	CHEMBL1771099
IUPHAR	N/A
BindingDB	50342698
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	9.0 nM	PMID21273063	BindingDB,ChEMBL
EC50	18.0 nM	PMID21273063	BindingDB,ChEMBL

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