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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesRattus norvegicus (Rat)
GenePtger2
SynonymEP2 receptor
PGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length357
Amino acid sequenceMDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProtQ62928
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4909
IUPHAR341
DrugBankN/A

Ligand

NameCHEMBL425950
Molecular formulaC24H31NO4S
IUPAC name5-[3-[(2S)-2-[4-(4-ethylphenyl)-3-hydroxybutyl]-5-oxopyrrolidin-1-yl]propyl]thiophene-2-carboxylic acid
Molecular weight429.575
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP4.6
SynonymsSCHEMBL4996181
5-(3-((S)-2-(4-(4-ethylphenyl)-3-hydroxybutyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylic acid
BDBM50181280
Inchi KeyHGNFVFHSIKQWQB-XJDOXCRVSA-N
Inchi IDInChI=1S/C24H31NO4S/c1-2-17-5-7-18(8-6-17)16-20(26)11-9-19-10-14-23(27)25(19)15-3-4-21-12-13-22(30-21)24(28)29/h5-8,12-13,19-20,26H,2-4,9-11,14-16H2,1H3,(H,28,29)/t19-,20?/m0/s1
PubChem CID44409693
ChEMBLCHEMBL425950
IUPHARN/A
BindingDB50181280
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501200.0 nMPMID16442794BindingDB,ChEMBL

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