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Name | Pyroglutamylated RF-amide peptide receptor |
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Species | Homo sapiens (Human) |
Gene | QRFPR |
Synonym | QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 [ Show all ] |
Disease | N/A |
Length | 431 |
Amino acid sequence | MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH |
UniProt | Q96P65 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q96P65 |
3D structure model | This predicted structure model is from GPCR-EXP Q96P65. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5852 |
IUPHAR | 333 |
DrugBank | N/A |
Name | CHEMBL3287821 |
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Molecular formula | C19H24N2OS2 |
IUPAC name | N-[3-(cyclopentylsulfanylmethyl)-4-methoxyphenyl]-N'-methylthiophene-2-carboximidamide |
Molecular weight | 360.534 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.6 |
Synonyms | BDBM50020022 |
Inchi Key | HEWBOAJFYPRKLD-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H24N2OS2/c1-20-19(18-8-5-11-23-18)21-15-9-10-17(22-2)14(12-15)13-24-16-6-3-4-7-16/h5,8-12,16H,3-4,6-7,13H2,1-2H3,(H,20,21) |
PubChem CID | 90644585 |
ChEMBL | CHEMBL3287821 |
IUPHAR | N/A |
BindingDB | 50020022 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 251.0 nM | PMID24900874 | BindingDB |
IC50 | 251.19 nM | PMID24900874 | ChEMBL |
IC50 | 630.96 nM | PMID24900874 | ChEMBL |
IC50 | 631.0 nM | PMID24900874 | BindingDB |
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