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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	CHEMBL1224219
Molecular formula	C16H14ClN3O2
IUPAC name	2-[2-(3-chlorophenyl)ethoxymethyl]-3H-pyrido[2,3-d]pyrimidin-4-one
Molecular weight	315.757
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.4
Synonyms	BDBM50325924 SCHEMBL1866888 2-((3-chlorophenethyloxy)methyl)pyrido[2,3-d]pyrimidin-4(3H)-one
Inchi Key	HEKFYWONLKTJOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14ClN3O2/c17-12-4-1-3-11(9-12)6-8-22-10-14-19-15-13(16(21)20-14)5-2-7-18-15/h1-5,7,9H,6,8,10H2,(H,18,19,20,21)
PubChem CID	135899178
ChEMBL	CHEMBL1224219
IUPHAR	N/A
BindingDB	50325924
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	140.0 nM	PMID20724150	BindingDB,ChEMBL
IC50	640.0 nM	PMID20724150	BindingDB,ChEMBL

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