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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL1078960
Molecular formula	C24H28N4O3S
IUPAC name	1-[4-[[4-(2-amino-2-methylpropyl)phenyl]sulfamoyl]phenyl]-3-(4-methylphenyl)urea
Molecular weight	452.573
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	3.3
Synonyms	N-(4-(2-amino-2-methylpropyl)phenyl)-4-(3-p-tolylureido)benzenesulfonamide BDBM50311115
Inchi Key	APRNMJWYFKJVAT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H28N4O3S/c1-17-4-8-19(9-5-17)26-23(29)27-20-12-14-22(15-13-20)32(30,31)28-21-10-6-18(7-11-21)16-24(2,3)25/h4-15,28H,16,25H2,1-3H3,(H2,26,27,29)
PubChem CID	46882270
ChEMBL	CHEMBL1078960
IUPHAR	N/A
BindingDB	50311115
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	3.0 %	PMID19767208	ChEMBL
IC50	77.0 nM	PMID19767208	BindingDB,ChEMBL

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