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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL336816
Molecular formula	C27H29N5O
IUPAC name	N-[2-[4-[cyano(pyridin-3-yl)methyl]piperazin-1-yl]ethyl]-2,2-diphenylacetamide
Molecular weight	439.563
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	SCHEMBL9853092 BDBM50003484 N-{2-[4-(Cyano-pyridin-3-yl-methyl)-piperazin-1-yl]-ethyl}-2,2-diphenyl-acetamide; hydrate
Inchi Key	HBGGHIHCBLBGLS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H29N5O/c28-20-25(24-12-7-13-29-21-24)32-18-16-31(17-19-32)15-14-30-27(33)26(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,21,25-26H,14-19H2,(H,30,33)
PubChem CID	10433324
ChEMBL	CHEMBL336816
IUPHAR	N/A
BindingDB	50003484
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	0.29 mg.kg-1	PMID1433215	ChEMBL

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