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GPCR

NameHistamine H3 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH3
SynonymH3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
UniProtQ9JI35
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5076
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL11515
Molecular formulaC22H27N3
IUPAC name2-[2-(3,3-diphenylpropyl)-1H-imidazol-5-yl]-N-ethylethanamine
Molecular weight333.479
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP4.4
SynonymsBDBM50409189
N-Ethyl-2-(3,3-diphenylpropyl)-1H-imidazole-4-ethanamine
Inchi KeyHANVENUBICTJAH-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H27N3/c1-2-23-16-15-20-17-24-22(25-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21,23H,2,13-16H2,1H3,(H,24,25)
PubChem CID10688111
ChEMBLCHEMBL11515
IUPHARN/A
BindingDB50409189
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Kd<1000.0 nMPMID10737740BindingDB,ChEMBL

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