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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Type-1B angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr1b
Synonym	Angiotensin II type-1B receptor AT1B AT3
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
UniProt	P29089
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL292316
Molecular formula	C23H24N6O2
IUPAC name	6-butyl-3-methyl-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidine-2,4-dione
Molecular weight	416.485
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.4
Synonyms	BDBM50285167 L010632 6-Butyl-3-methyl-1-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-pyrimidine-2,4-dione
Inchi Key	GSNMARCHVLZNCA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24N6O2/c1-3-4-7-18-14-21(30)28(2)23(31)29(18)15-16-10-12-17(13-11-16)19-8-5-6-9-20(19)22-24-26-27-25-22/h5-6,8-14H,3-4,7,15H2,1-2H3,(H,24,25,26,27)
PubChem CID	44211708
ChEMBL	CHEMBL292316
IUPHAR	N/A
BindingDB	50285167
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.5 nM	, Bioorg. Med. Chem. Lett., (1995) 5:18:2071	BindingDB,ChEMBL

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