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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	4-(2-Aminopropyl)-2-methoxyphenol
Molecular formula	C10H15NO2
IUPAC name	4-(2-aminopropyl)-2-methoxyphenol
Molecular weight	181.235
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.6
Synonyms	13026-44-3 CTK6J6913 3-O-Methyl-a-methyldopamine AKOS017269172 Phenol, 4-(2-aminopropyl)-2-methoxy- 3-13-00-02250 (Beilstein Handbook Reference) AC1L52Y5 LS-103955 3-O-Methyl-alpha-methyldopamine BDBM50404648 SCHEMBL9434236 4-hydroxy-3-methoxyamphetamine CHEMBL1347 3-Methoxy-4-hydroxyphenylisopropylamine AKOS000152652 NCI60_001388 4'-hydroxy-3'-methoxyamphetamine BRN 2804928 [ Show all ]
Inchi Key	GPBOYXOSSQEJBH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H15NO2/c1-7(11)5-8-3-4-9(12)10(6-8)13-2/h3-4,6-7,12H,5,11H2,1-2H3
PubChem CID	197139
ChEMBL	CHEMBL1347
IUPHAR	N/A
BindingDB	50404648
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	3548.13 nM	PMID7411554	BindingDB,ChEMBL
Kd	6456.54 nM	PMID7411554	ChEMBL
Kd	6457.0 nM	PMID7411554	BindingDB

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