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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Bos taurus (Bovine)
Gene	ADRA2A
Synonym	Alpha-2A adrenoceptor Alpha-2A adrenoreceptor Alpha-2AAR Alpha-2D adrenergic receptor
Disease	N/A for non-human GPCRs
Length	452
Amino acid sequence	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	Q28838
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4744
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	5-Meo-dpac
Molecular formula	C16H25NO2
IUPAC name	5-methoxy-N,N-dipropyl-3,4-dihydro-2H-chromen-3-amine
Molecular weight	263.381
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.8
Synonyms	CTK8G5655 5-Methoxy-3-(di-n-propylamino)chroman L023817 2H-1-Benzopyran-3-amine, 3,4-dihydro-5-methoxy-N,N-dipropyl- D0L8NG (5-Methoxy-chroman-3-yl)-dipropyl-amine 5-Methoxy-3-(dipropylamino)chroman SCHEMBL2217080 3-(Di-n-propylamino)-5-methoxychroman AC1MIZ4R CHEMBL283606 5-methoxy-3,4-dihydro-N,N-dipropyl-2H-[1]-benzopyran-3-amine GOWYIQOIWRLZLO-UHFFFAOYSA-N 110927-00-9 5-methoxy-N,N-dipropyl-3,4-dihydro-2H-chromen-3-amine 3-Dipropylamino-5-methyloxychroman BDBM50036862 [ Show all ]
Inchi Key	GOWYIQOIWRLZLO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO2/c1-4-9-17(10-5-2)13-11-14-15(18-3)7-6-8-16(14)19-12-13/h6-8,13H,4-5,9-12H2,1-3H3
PubChem CID	3082597
ChEMBL	CHEMBL283606
IUPHAR	N/A
BindingDB	50036862
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	780.0 nM	PMID7912735	BindingDB,ChEMBL
IC50	4000.0 nM	PMID7912735	ChEMBL
IC50	9100.0 nM	PMID7912735	BindingDB,ChEMBL

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