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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
WEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPI
QVRDAGLSFKDDMPKSDVNKEYYTQNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECK
RGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQ
FGEIRTITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKW

The query sequence (length=288) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8ch6:U 295 288 1.0000 0.9763 1.0000 0.0 7a5p:P, 8c6j:M, 6ff4:P, 6ff7:P, 9fmd:O, 8i0p:O, 8i0r:O, 8i0s:O, 8i0t:O, 8i0u:O, 8i0v:O, 8i0w:O, 6icz:O, 6id0:O, 6id1:O, 5mqf:P, 6qdv:M, 7qtt:U, 8ro2:O, 7w59:O, 7w5a:O, 7w5b:O, 5xjc:O, 5yzg:O, 5z56:O, 5z57:O, 6zym:P
2 7abi:P 237 288 0.8021 0.9747 0.8021 3.34e-165 7aav:P, 7abg:P
3 8ro0:O 342 294 0.6250 0.5263 0.6122 3.26e-136 8ro1:O
4 3jb9:a 255 111 0.1840 0.2078 0.4775 1.42e-36
5 3jb9:a 255 30 0.0417 0.0471 0.4000 0.012
6 5gm6:Q 185 139 0.1562 0.2432 0.3237 3.24e-17 5gmk:Q, 5wsg:Q, 5ylz:M
7 5mps:N 227 126 0.1597 0.2026 0.3651 4.18e-17 5lj3:N, 5lj5:N, 5mq0:N
8 6exn:N 242 126 0.1597 0.1901 0.3651 5.36e-17 6bk8:F
9 7b9v:N 264 126 0.1597 0.1742 0.3651 6.73e-17
10 5y88:M 182 107 0.1389 0.2198 0.3738 9.23e-17
11 7dco:Q 292 126 0.1597 0.1575 0.3651 9.53e-17 6j6g:Q, 6j6h:Q, 6j6n:Q, 6j6q:Q
12 5lqw:F 218 131 0.1250 0.1651 0.2748 6.57e-07
13 3jb9:Y 261 169 0.1597 0.1762 0.2722 3.00e-06
14 6jvx:A 87 80 0.0972 0.3218 0.3500 3.63e-06 6jvy:A
15 7dco:R 261 160 0.1493 0.1648 0.2687 1.30e-05 7b9v:M, 6bk8:G, 6exn:M, 5gm6:R, 5gmk:R, 6j6g:R, 6j6h:R, 6j6n:R, 6j6q:R, 5lj3:M, 5lj5:M, 5mps:M, 5mq0:M, 3tp2:A, 3tp2:B, 3u1l:A, 3u1m:A, 5wsg:R, 5y88:N, 5ylz:N
16 8pv1:CI 152 75 0.0868 0.1645 0.3333 4.78e-05 8i9p:CI, 8i9r:CI, 8i9t:CI, 8i9v:CI, 8i9w:CI, 8i9x:CI, 8i9y:CI, 8i9z:CI, 8ia0:CI, 8pv3:CI, 8pv4:CI, 8pv7:CI, 8pvk:CI
17 5ifm:C 256 80 0.0833 0.0938 0.3000 3.56e-04 5ifm:A
18 5o1y:A 163 58 0.0625 0.1104 0.3103 0.002 5o1z:A, 5o20:A
19 7uj1:B 270 88 0.0868 0.0926 0.2841 0.002 7pu5:B, 7pu5:D, 7pu5:H, 7pu5:J, 7pu5:L, 7sp0:B, 7uj1:A
20 5kw6:A 201 76 0.0694 0.0995 0.2632 0.006 5kvy:A, 5kvy:B, 5kw1:A, 5kw1:B, 5kw6:B, 7q8a:B, 7q8a:A, 2qfj:A, 2qfj:B, 7z3x:A, 7z3x:B
21 5kw6:A 201 103 0.0799 0.1144 0.2233 0.86 5kvy:A, 5kvy:B, 5kw1:A, 5kw1:B, 5kw6:B, 7q8a:B, 7q8a:A, 2qfj:A, 2qfj:B, 7z3x:A, 7z3x:B
22 5en1:A 184 46 0.0521 0.0815 0.3261 0.008 8hni:A, 8hni:B, 8hni:G, 8hni:I, 8hni:H, 8hni:E, 8hni:K, 8hni:C, 8hni:D, 8hni:J, 8hni:F, 8hni:L, 5ho4:A, 7wm3:A, 7wm3:B, 7wm3:C, 7wm3:D, 5wwe:A, 5wwf:A, 5wwf:C, 5wwg:A
23 5en1:A 184 77 0.0833 0.1304 0.3117 0.46 8hni:A, 8hni:B, 8hni:G, 8hni:I, 8hni:H, 8hni:E, 8hni:K, 8hni:C, 8hni:D, 8hni:J, 8hni:F, 8hni:L, 5ho4:A, 7wm3:A, 7wm3:B, 7wm3:C, 7wm3:D, 5wwe:A, 5wwf:A, 5wwf:C, 5wwg:A
24 8esq:o 137 66 0.0729 0.1533 0.3182 0.008 8esr:o, 8etg:o, 8eth:o, 8eti:o, 8eup:o, 8euy:o, 8ev3:o
25 7q33:A 93 73 0.0868 0.2688 0.3425 0.009 6pai:D, 6q0r:D, 6q0v:D, 6q0w:D, 6sj7:C, 6ud7:C, 6ue5:C
26 2mgz:B 105 81 0.0799 0.2190 0.2840 0.010 4ch1:A, 4cio:A, 2ru3:A
27 8ch6:V 285 98 0.1111 0.1123 0.3265 0.011 7qtt:V
28 7ohx:o 112 75 0.0660 0.1696 0.2533 0.012
29 6c0f:o 133 75 0.0660 0.1429 0.2533 0.013 7btb:o, 6cb1:o, 8e5t:o, 6elz:o, 6em1:o, 6em3:o, 6em4:o, 6em5:o, 3jct:o, 6m62:o, 7nac:o, 7ohp:o, 7ohq:o, 7ohr:o, 7ohs:o, 7ohv:o, 7ohw:o, 7r6q:o, 7r7a:o, 7u0h:o, 7uoo:o, 7uqb:o, 7uqz:o, 7v08:o, 8v83:o, 8v84:o, 8v87:o, 6ylx:o, 6yly:o, 5z3g:E
30 8i0s:Y 320 98 0.1111 0.1000 0.3265 0.015 8i0t:Y, 8i0u:Y, 8i0v:Y
31 7dco:4 174 69 0.0660 0.1092 0.2754 0.017 6g90:R, 5gm6:e, 5nrl:R, 7oqb:R, 7oqe:R, 5zwm:4
32 6n7p:A 186 80 0.0833 0.1290 0.3000 0.023 6n7r:A, 6n7x:A, 7oqc:B, 7oqe:B, 8w2o:A, 5zwn:Q
33 9gpj:A 184 83 0.0694 0.1087 0.2410 0.026 6dcl:A, 6dcl:B, 9f4d:A, 9f4e:A, 9f4f:A, 9f4g:A, 9f4h:A, 9f4j:A, 9f4k:A, 9f4l:A, 9f4m:A, 9f4n:A, 9f4o:A, 9f4p:A, 9f4q:A, 9f4r:A, 9f4s:A, 9f4t:A, 9f4u:A, 9f4v:A, 9f4w:A, 9f4x:A, 9f4y:A, 9f4z:A, 9f50:A, 9f51:A, 9f52:A, 9f53:A, 9f54:A, 9f55:A, 9f5c:A, 9f5d:A, 9f5e:A, 9f5f:A, 9f5g:A, 9f5k:A, 9f7f:A, 9f7h:A, 5mpg:A, 5mpl:A, 1pgz:A, 1po6:A, 8rzv:A, 1u1k:A, 1u1l:A, 1u1m:A, 1u1n:A, 1u1o:A, 1u1p:A, 1u1q:A, 1u1r:A, 2up1:A, 4yoe:A
34 9gpj:A 184 79 0.0868 0.1359 0.3165 0.068 6dcl:A, 6dcl:B, 9f4d:A, 9f4e:A, 9f4f:A, 9f4g:A, 9f4h:A, 9f4j:A, 9f4k:A, 9f4l:A, 9f4m:A, 9f4n:A, 9f4o:A, 9f4p:A, 9f4q:A, 9f4r:A, 9f4s:A, 9f4t:A, 9f4u:A, 9f4v:A, 9f4w:A, 9f4x:A, 9f4y:A, 9f4z:A, 9f50:A, 9f51:A, 9f52:A, 9f53:A, 9f54:A, 9f55:A, 9f5c:A, 9f5d:A, 9f5e:A, 9f5f:A, 9f5g:A, 9f5k:A, 9f7f:A, 9f7h:A, 5mpg:A, 5mpl:A, 1pgz:A, 1po6:A, 8rzv:A, 1u1k:A, 1u1l:A, 1u1m:A, 1u1n:A, 1u1o:A, 1u1p:A, 1u1q:A, 1u1r:A, 2up1:A, 4yoe:A
35 2xb2:D 89 75 0.0660 0.2135 0.2533 0.027 2xb2:Z
36 4ed5:B 169 62 0.0833 0.1420 0.3871 0.028 4ed5:A
37 6dnh:C 117 74 0.0625 0.1538 0.2432 0.032 8e3i:C, 8e3q:C, 6fuw:C, 8r8r:C, 2rhk:D, 6urg:C, 6uro:C
38 2n7c:A 89 62 0.0694 0.2247 0.3226 0.041
39 4lmz:A 176 55 0.0590 0.0966 0.3091 0.048 3nmr:A, 3nna:A, 3nnc:A, 3nnh:A, 3nnh:C, 3nnh:B, 3nnh:D
40 4lmz:A 176 61 0.0590 0.0966 0.2787 0.46 3nmr:A, 3nna:A, 3nnc:A, 3nnh:A, 3nnh:C, 3nnh:B, 3nnh:D
41 2mqo:A 105 51 0.0486 0.1333 0.2745 0.050
42 2d9n:A 77 21 0.0312 0.1169 0.4286 0.064 2rhk:C
43 2xs2:A 87 40 0.0417 0.1379 0.3000 0.071 2xs5:A, 2xs5:B, 2xs7:A
44 7zew:A 117 74 0.0764 0.1880 0.2973 0.087 7zex:A
45 7dvq:Y 140 73 0.0694 0.1429 0.2740 0.093 8i0p:Y, 8i0r:Y
46 8xxm:3G 84 80 0.1007 0.3452 0.3625 0.098 5k0y:O, 8pj1:o, 8pj2:o, 8pj3:o, 8pj4:o, 8pj5:o, 8pj6:o
47 7pcv:A 116 78 0.0799 0.1983 0.2949 0.14 2lk0:A, 2lk1:A, 7pcv:B, 7pdv:E, 7pdv:A, 7pdv:C, 7pdv:G
48 8fkp:SH 150 72 0.0694 0.1333 0.2778 0.14 8fkq:SH, 8fkr:SH, 8fks:SH, 8fkt:SH, 8fku:SH, 8fkv:SH, 8fkw:SH, 8fkx:SH, 8fky:SH, 8fkz:SH, 8fl2:SH, 8fl6:SH, 8fla:SH, 8fld:SH, 8ine:t, 8inf:t, 8ipx:t, 8ipy:t, 8ir3:t
49 1wtb:A 79 67 0.0590 0.2152 0.2537 0.18 1x0f:A
50 2rs2:A 84 32 0.0417 0.1429 0.3750 0.18
51 2cqe:A 98 20 0.0347 0.1020 0.5000 0.20
52 1fnx:H 174 114 0.1111 0.1839 0.2807 0.28 1fxl:A, 1g2e:A
53 6g90:B 193 71 0.0729 0.1088 0.2958 0.29
54 4cs7:C 172 26 0.0382 0.0640 0.4231 0.29 4cs7:A, 4cs7:B, 4cs7:E, 4cs8:A, 4cs8:B, 4cs8:C, 4cs8:E, 4cs9:A, 4cs9:B, 4cs9:C, 4cs9:E, 4csa:C, 4csa:A, 4csa:B, 4csa:E
55 3jb9:k 89 78 0.0764 0.2472 0.2821 0.33
56 1rk8:A 87 83 0.0625 0.2069 0.2169 0.33
57 5x8p:v 190 73 0.0625 0.0947 0.2466 0.34 5mmj:v, 5mmm:v, 5x8r:v
58 5ith:A 80 75 0.0694 0.2500 0.2667 0.37 5o3j:A
59 2i2y:A 150 54 0.0625 0.1200 0.3333 0.42 9asq:H, 5bmg:A, 5bmg:B, 5bmg:H, 5bmg:D, 5bmg:E, 5bmg:F, 5bmg:G, 5bmh:A, 3v3x:C, 3v3x:D
60 6qx9:1K 201 77 0.0764 0.1095 0.2857 0.42 7b0y:b, 4pjo:K, 4pjo:k, 4pjo:N, 4pjo:n, 8r08:1K, 7vpx:O
61 2n82:B 104 71 0.0694 0.1923 0.2817 0.51 2err:A, 7vrl:B
62 5x3z:A 96 64 0.0521 0.1562 0.2344 0.52
63 8h72:A 328 43 0.0521 0.0457 0.3488 0.60 8h72:B
64 5mqf:o 223 74 0.0764 0.0987 0.2973 0.64 6id1:y, 7w59:y, 7w5a:y, 7w5b:y
65 6eoj:B 94 21 0.0312 0.0957 0.4286 0.70 7zgp:B, 7zgr:B
66 4bs2:A 174 68 0.0625 0.1034 0.2647 1.1 4iuf:A, 4y00:A, 4y00:B, 4y00:C, 4y00:D, 4y0f:A, 4y0f:B
67 8i0v:4 161 75 0.0729 0.1304 0.2800 1.1
68 4pkd:B 240 87 0.0868 0.1042 0.2874 1.3 1aud:A, 7b0y:c, 3bo2:A, 3bo3:A, 3bo4:A, 4c4w:A, 4c4w:E, 3cul:A, 3cul:B, 3cun:A, 3cun:B, 7d7v:C, 5ddo:G, 5ddo:C, 5ddp:D, 5ddp:C, 5ddq:D, 5ddq:C, 5ddr:D, 5ddr:C, 7dlz:A, 7dlz:B, 1drz:A, 7dwh:A, 7dwh:B, 1dz5:A, 1dz5:B, 3egz:A, 5fj4:A, 5fj4:E, 3g8s:A, 3g8s:B, 3g8s:C, 3g8s:D, 3g8t:A, 3g8t:B, 3g8t:C, 3g8t:D, 3g96:A, 3g96:B, 3g96:C, 3g96:D, 3g9c:A, 3g9c:B, 3g9c:C, 3g9c:D, 8gxb:C, 8gxb:D, 8gxb:F, 8gxc:C, 8gxc:D, 8gxc:F, 3hhn:B, 3hhn:D, 3iin:A, 3irw:P, 3iwn:C, 3iwn:D, 8jy0:A, 8jy0:C, 8jy0:E, 3k0j:A, 3k0j:B, 3l3c:A, 3l3c:B, 3l3c:C, 3l3c:D, 6las:E, 6las:D, 6las:C, 6lau:E, 6lau:D, 6lau:C, 6lax:D, 6lax:E, 6lax:C, 6laz:D, 6laz:E, 6laz:C, 1m5k:C, 1m5k:F, 1m5o:C, 1m5o:F, 1m5p:C, 1m5p:F, 1m5v:C, 1m5v:F, 3mum:P, 3mur:P, 3mut:P, 3muv:P, 3mxh:P, 2nz4:A, 2nz4:B, 2nz4:C, 2nz4:D, 2oih:A, 2oj3:A, 3p49:B, 4pr6:A, 4prf:A, 7qr3:A, 7qr3:B, 7qr4:A, 6qx9:1A, 3r1h:A, 3r1h:D, 3r1l:A, 3r1l:D, 1sj3:P, 1sj4:P, 1sjf:A, 6sqn:A, 6sqn:B, 6sqn:C, 6sqq:AAA, 6sqq:BBB, 6sqq:CCC, 1u6b:A, 3ucu:P, 3ucz:P, 3ud3:P, 3ud4:P, 1urn:A, 1urn:B, 1urn:C, 1vbx:A, 1vby:A, 1vbz:A, 1vc0:A, 1vc5:A, 1vc6:A, 7vpx:M, 4w90:B, 4w92:B, 1zzn:A
69 8by6:B 152 121 0.1007 0.1908 0.2397 1.6 7abg:A1, 6d0y:A, 1h2t:Z, 1h2u:X, 1h2u:Y, 1n52:B, 5oo6:B, 5oo6:E, 5oo6:H, 5oo6:K, 5oo6:N, 5oo6:Q, 5oo6:T, 5oo6:W, 5oob:D, 5oob:J, 5oob:B, 5oob:G, 8pmp:B, 8pnt:B, 8srr:B, 8suy:B
70 7c06:A 193 53 0.0625 0.0933 0.3396 1.6 7c06:G, 7c06:D, 7c06:J, 7c06:M, 7c06:P, 7c06:S, 7c06:V, 7c06:Y, 7c07:A, 7c07:G, 7c07:D, 7c07:J, 7c07:M, 7c07:P, 7c07:S, 7c07:V, 7c07:Y, 7c08:A, 7c08:G, 7c08:D, 7c08:J, 7c08:M, 7c08:P, 7c08:S, 7c08:V, 7c08:Y, 4yh8:A
71 6zj3:Sg 199 48 0.0451 0.0653 0.2708 1.7
72 6so9:A 112 60 0.0556 0.1429 0.2667 3.5
73 4f02:A 175 79 0.0694 0.1143 0.2532 3.9 1cvj:A, 1cvj:B, 1cvj:C, 1cvj:D, 1cvj:E, 1cvj:F, 1cvj:G, 1cvj:H, 4f02:D
74 2cjk:A 167 122 0.1181 0.2036 0.2787 4.3 2km8:C
75 3hkz:D 264 94 0.0938 0.1023 0.2872 5.2 4ayb:D, 3hkz:O, 2pa8:D, 2pmz:D, 2pmz:S, 4v8s:AS, 4v8s:BD, 2waq:D, 2wb1:D, 2wb1:S, 2y0s:D, 2y0s:S
76 8any:A6 74 65 0.0521 0.2027 0.2308 5.2
77 8y6o:W 167 78 0.0625 0.1078 0.2308 5.5
78 6lra:L 220 68 0.0799 0.1045 0.3382 6.0 5eor:L, 6f7t:L, 6f7t:A, 3ffd:B, 7fgj:L, 7fgl:L, 7fgr:L, 2otu:A, 2otu:C, 2otu:E, 2otu:G, 2otw:A, 2otw:C, 2qhr:L, 7vtj:L
79 3d2w:A 72 51 0.0451 0.1806 0.2549 6.0
80 6snj:A 131 40 0.0486 0.1069 0.3500 6.8 6gbm:B
81 4c3b:C 178 138 0.1146 0.1854 0.2391 6.9 4c3b:A, 4c3b:B, 4c3b:D, 4c3b:E, 4c3b:F, 4c3b:G, 4c3b:H, 4c3b:I, 4c3b:J, 4c3b:K, 4c3b:L, 4c3b:M, 4c3b:N, 4c3b:O, 4c3b:P, 4c3e:A, 4c3e:B, 4c3e:C, 4c3e:D, 4c3e:E, 4c3e:F, 4c3e:G, 4c3e:H, 4c3e:I, 4c3e:J, 4c3e:K, 4c3e:L, 4c3e:M, 4c3e:N, 4c3e:O, 4c3e:P, 6g0y:F, 6g0y:E, 6g0y:A, 6g0y:C, 6pzq:B, 6pzq:D
82 4qqb:A 169 93 0.0903 0.1538 0.2796 7.2 1b7f:A, 1b7f:B, 4qqb:B
83 6zu5:LL0 164 43 0.0521 0.0915 0.3488 8.0
84 5upm:A 753 33 0.0451 0.0173 0.3939 8.3 5t4a:A, 5t4c:A, 5t4g:A, 5upi:A, 5upn:A, 5upo:A, 5v1w:A
85 6r5k:H 394 94 0.0868 0.0635 0.2660 10.0 6r5k:D, 6r5k:F

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218