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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
VPGLGRGATGFDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQ
QFSDLKRKLAEVTEEEWLSIPEVGDGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDIND
IKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLP
QSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENAR
KVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVI
GIGEEDRKHTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHRESLEALLQRAVAHCPKAEVLWLMG
AKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYERARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAA
QDLCEEALRHYEDFPKLWMMKGQIEEQKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNP
KNPGLWLESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHDPHVLLAVAKLFWSQ
RKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKRCESAEPRHGELWCAVSKDIANWQKKIGDILRLVA
GRI

The query sequence (length=803) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6qw6:5J 803 803 1.0000 1.0000 1.0000 0.0 8h6e:4G, 8h6j:4G, 8h6k:4G, 8h6l:4G, 8qp8:N, 6qx9:5J, 8y6o:G
2 8r09:N 834 841 0.9577 0.9221 0.9144 0.0 6ahd:N, 5o9z:G, 8q7n:N, 8qo9:N, 8qpe:N, 8qzs:N, 8r0b:N, 8rc0:E, 8rm5:N
3 8qoz:N 457 377 0.3313 0.5821 0.7056 4.00e-147 8qpa:N, 8qpb:N
4 8qoz:N 457 377 0.2441 0.4289 0.5199 8.07e-105 8qpa:N, 8qpb:N
5 8qoz:N 457 224 0.0672 0.1182 0.2411 2.14e-08 8qpa:N, 8qpb:N
6 8qoz:N 457 262 0.0785 0.1379 0.2405 7.43e-07 8qpa:N, 8qpb:N
7 8qoz:N 457 117 0.0423 0.0744 0.2906 8.17e-07 8qpa:N, 8qpb:N
8 5nrl:J 800 845 0.2864 0.2875 0.2722 3.91e-88 5gan:J, 5gap:J
9 3jcm:G 734 797 0.2665 0.2916 0.2685 3.35e-70 5zwm:N, 5zwo:N
10 8qpk:N 133 139 0.1469 0.8872 0.8489 2.89e-52
11 8c6j:S 635 533 0.1494 0.1890 0.2251 1.72e-15 7abi:O, 8ch6:X, 6ff4:O, 8i0r:J, 8i0s:J, 8i0t:J, 5mqf:O, 7qtt:X, 6zym:O
12 8c6j:S 635 103 0.0286 0.0362 0.2233 0.002 7abi:O, 8ch6:X, 6ff4:O, 8i0r:J, 8i0s:J, 8i0t:J, 5mqf:O, 7qtt:X, 6zym:O
13 8ro0:J 574 500 0.1370 0.1916 0.2200 3.12e-14 8ro1:J
14 8ro0:J 574 103 0.0324 0.0453 0.2524 2.44e-06 8ro1:J
15 8ro0:J 574 385 0.1096 0.1533 0.2286 0.013 8ro1:J
16 8ro0:J 574 215 0.0548 0.0767 0.2047 0.032 8ro1:J
17 8i0w:J 571 249 0.0710 0.0998 0.2289 1.81e-09 7dvq:J, 8i0u:J, 8i0v:J, 6icz:J, 6id0:J, 6id1:J, 6qdv:S, 7w59:J, 7w5a:J, 7w5b:J, 5xjc:J, 5yzg:J, 5z56:J, 5z57:J, 5z58:J
18 8i0w:J 571 255 0.0747 0.1051 0.2353 2.23e-06 7dvq:J, 8i0u:J, 8i0v:J, 6icz:J, 6id0:J, 6id1:J, 6qdv:S, 7w59:J, 7w5a:J, 7w5b:J, 5xjc:J, 5yzg:J, 5z56:J, 5z57:J, 5z58:J
19 8i0w:J 571 530 0.1370 0.1926 0.2075 4.00e-06 7dvq:J, 8i0u:J, 8i0v:J, 6icz:J, 6id0:J, 6id1:J, 6qdv:S, 7w59:J, 7w5a:J, 7w5b:J, 5xjc:J, 5yzg:J, 5z56:J, 5z57:J, 5z58:J
20 8i0w:J 571 95 0.0262 0.0368 0.2211 0.002 7dvq:J, 8i0u:J, 8i0v:J, 6icz:J, 6id0:J, 6id1:J, 6qdv:S, 7w59:J, 7w5a:J, 7w5b:J, 5xjc:J, 5yzg:J, 5z56:J, 5z57:J, 5z58:J
21 6rxy:Cz 275 265 0.0772 0.2255 0.2340 1.26e-06 6rxz:Cz
22 8chy:A 272 253 0.0710 0.2096 0.2253 3.39e-05 8bu0:A, 8cig:A, 8ckr:A, 8cqp:C, 8cqq:A
23 8chy:A 272 251 0.0660 0.1949 0.2112 4.76e-05 8bu0:A, 8cig:A, 8ckr:A, 8cqp:C, 8cqq:A
24 8chy:A 272 222 0.0585 0.1728 0.2117 5.64e-05 8bu0:A, 8cig:A, 8ckr:A, 8cqp:C, 8cqq:A
25 8chy:A 272 241 0.0660 0.1949 0.2199 9.83e-05 8bu0:A, 8cig:A, 8ckr:A, 8cqp:C, 8cqq:A
26 8chy:A 272 221 0.0635 0.1875 0.2308 1.82e-04 8bu0:A, 8cig:A, 8ckr:A, 8cqp:C, 8cqq:A
27 8chy:A 272 272 0.0697 0.2059 0.2059 3.56e-04 8bu0:A, 8cig:A, 8ckr:A, 8cqp:C, 8cqq:A
28 8chy:A 272 229 0.0585 0.1728 0.2052 0.003 8bu0:A, 8cig:A, 8ckr:A, 8cqp:C, 8cqq:A
29 3jb9:R 575 227 0.0648 0.0904 0.2291 1.53e-04
30 3jb9:R 575 228 0.0648 0.0904 0.2281 0.008
31 3jb9:R 575 230 0.0585 0.0817 0.2043 0.50
32 5gmk:d 549 179 0.0535 0.0783 0.2402 1.83e-04 5gm6:d, 5wsg:d
33 5gmk:d 549 146 0.0411 0.0601 0.2260 0.65 5gm6:d, 5wsg:d
34 5gmk:d 549 91 0.0262 0.0383 0.2308 1.1 5gm6:d, 5wsg:d
35 5gmk:d 549 91 0.0262 0.0383 0.2308 2.4 5gm6:d, 5wsg:d
36 5gmk:d 549 87 0.0237 0.0346 0.2184 6.2 5gm6:d, 5wsg:d
37 7d5s:RD 265 198 0.0548 0.1660 0.2222 2.58e-04 6lqu:RD, 7suk:NJ, 5wlc:NJ
38 7d5s:RD 265 220 0.0648 0.1962 0.2364 0.84 6lqu:RD, 7suk:NJ, 5wlc:NJ
39 6j6g:d 566 104 0.0336 0.0477 0.2596 3.12e-04 7b9v:S, 6j6h:d, 6j6n:d, 6j6q:d, 5lqw:R
40 6j6g:d 566 91 0.0262 0.0371 0.2308 1.2 7b9v:S, 6j6h:d, 6j6n:d, 6j6q:d, 5lqw:R
41 6j6g:d 566 84 0.0237 0.0336 0.2262 3.9 7b9v:S, 6j6h:d, 6j6n:d, 6j6q:d, 5lqw:R
42 6j6g:d 566 91 0.0262 0.0371 0.2308 5.2 7b9v:S, 6j6h:d, 6j6n:d, 6j6q:d, 5lqw:R
43 7dco:J 554 104 0.0336 0.0487 0.2596 3.29e-04 5y88:I
44 7dco:J 554 146 0.0411 0.0596 0.2260 0.53 5y88:I
45 7dco:J 554 91 0.0262 0.0379 0.2308 1.2 5y88:I
46 7dco:J 554 87 0.0237 0.0343 0.2184 3.5 5y88:I
47 7dco:J 554 91 0.0262 0.0379 0.2308 4.9 5y88:I
48 7dco:J 554 147 0.0336 0.0487 0.1837 8.6 5y88:I
49 6bk8:T 483 112 0.0374 0.0621 0.2679 3.31e-04 6exn:S, 5lj3:S, 5lj5:S, 5mps:S, 5mq0:S
50 6bk8:T 483 91 0.0262 0.0435 0.2308 1.6 6exn:S, 5lj3:S, 5lj5:S, 5mps:S, 5mq0:S
51 6bk8:T 483 87 0.0237 0.0393 0.2184 4.2 6exn:S, 5lj3:S, 5lj5:S, 5mps:S, 5mq0:S
52 6bk8:T 483 91 0.0262 0.0435 0.2308 5.6 6exn:S, 5lj3:S, 5lj5:S, 5mps:S, 5mq0:S
53 5ylz:I 517 104 0.0336 0.0522 0.2596 3.50e-04
54 5ylz:I 517 146 0.0411 0.0638 0.2260 0.53
55 5ylz:I 517 91 0.0262 0.0406 0.2308 1.2
56 5ylz:I 517 87 0.0237 0.0368 0.2184 4.2
57 5ylz:I 517 91 0.0262 0.0406 0.2308 5.2
58 5ylz:I 517 147 0.0336 0.0522 0.1837 7.4
59 8ro2:I 753 332 0.0971 0.1036 0.2349 0.004
60 8ro2:I 753 191 0.0548 0.0584 0.2304 2.0
61 8ro2:I 753 406 0.1133 0.1208 0.2241 5.8
62 5oql:E 331 91 0.0299 0.0725 0.2637 0.032 6rxt:UF, 6rxu:UF, 6rxv:UF, 6rxy:UF, 6rxz:UF
63 5oql:E 331 64 0.0237 0.0574 0.2969 0.42 6rxt:UF, 6rxu:UF, 6rxv:UF, 6rxy:UF, 6rxz:UF
64 5oql:E 331 85 0.0249 0.0604 0.2353 4.0 6rxt:UF, 6rxu:UF, 6rxv:UF, 6rxy:UF, 6rxz:UF
65 7d4i:B6 377 63 0.0237 0.0504 0.3016 0.046 7ajt:UF, 7d5s:B6, 7d5t:B6, 7d63:B6, 6ke6:B6, 6lqp:B6, 6lqq:B6, 6lqr:B6, 6lqs:B6, 6lqt:B6, 6lqu:B6, 6lqv:B6, 6zqa:UF, 6zqb:UF, 6zqc:UF
66 7d4i:B6 377 90 0.0249 0.0531 0.2222 0.10 7ajt:UF, 7d5s:B6, 7d5t:B6, 7d63:B6, 6ke6:B6, 6lqp:B6, 6lqq:B6, 6lqr:B6, 6lqs:B6, 6lqt:B6, 6lqu:B6, 6lqv:B6, 6zqa:UF, 6zqb:UF, 6zqc:UF
67 7suk:LP 359 63 0.0237 0.0529 0.3016 0.048 5wlc:LP
68 7suk:LP 359 90 0.0249 0.0557 0.2222 0.077 5wlc:LP
69 7suk:LP 359 71 0.0199 0.0446 0.2254 9.1 5wlc:LP
70 6igz:A 740 114 0.0399 0.0432 0.2807 0.41 6qph:A, 6rhz:A, 6sl5:A, 6yxr:A
71 1na0:B 119 99 0.0299 0.2017 0.2424 0.55 1na3:A, 1na3:B
72 3t41:A 423 93 0.0262 0.0496 0.2258 0.78 3t41:B
73 2r02:A 697 105 0.0411 0.0473 0.3143 0.95 3c3o:A, 3c3q:A, 3c3r:A, 2r03:A, 2r05:A, 5v3r:A, 5wa1:A, 2xs1:A, 2xs8:A
74 6j6h:v 722 133 0.0486 0.0540 0.2932 1.7 6j6n:v, 6j6q:v
75 3kd7:A 102 97 0.0299 0.2353 0.2474 1.9 3kd7:B, 3kd7:C, 3kd7:D, 3kd7:E
76 3kd7:A 102 104 0.0324 0.2549 0.2500 4.3 3kd7:B, 3kd7:C, 3kd7:D, 3kd7:E
77 7zy4:B 306 46 0.0212 0.0556 0.3696 2.2 7zy4:A
78 7m0d:B 340 60 0.0224 0.0529 0.3000 3.2 2bcq:A, 2bcr:A, 2bcs:A, 2bcu:A, 2bcv:A, 3c5f:A, 3c5f:B, 3c5g:A, 3c5g:B, 5ca7:B, 5ca7:A, 5chg:A, 5chg:B, 5cj7:A, 5cj7:B, 5cp2:B, 5cr0:A, 5cr0:B, 5cwr:A, 5cwr:B, 5ddm:B, 5ddy:A, 5ddy:C, 5ddy:E, 5ddy:G, 5dkw:A, 5dkw:B, 4fo6:A, 2gws:A, 2gws:E, 2gws:I, 2gws:M, 3hw8:A, 3hwt:A, 3hx0:A, 3hx0:F, 3hx0:K, 3hx0:P, 5iii:A, 5iij:A, 5iik:A, 5iil:A, 5iim:A, 5iin:A, 5iio:A, 5iio:M, 5iio:E, 5iio:I, 4k4g:A, 4k4g:M, 4k4g:E, 4k4g:I, 4k4h:A, 4k4h:E, 4k4h:I, 4k4h:M, 4k4i:A, 4k4i:E, 4k4i:I, 4k4i:M, 7m07:A, 7m08:A, 7m09:A, 7m0a:A, 7m0b:A, 7m0c:A, 7m0d:A, 7m0e:A, 7m0e:B, 7m0e:C, 7m0e:D, 7m43:A, 7m44:A, 7m45:A, 7m46:A, 7m47:A, 7m48:A, 7m49:A, 7m4a:A, 7m4b:A, 7m4c:A, 7m4d:A, 7m4e:A, 7m4f:A, 7m4g:A, 7m4h:A, 7m4i:A, 7m4j:A, 7m4k:A, 7m4l:A, 3mda:A, 3mdc:A, 3mgh:A, 3mgh:C, 3mgi:A, 2pfn:A, 2pfo:A, 2pfp:A, 2pfq:A, 3pml:A, 3pml:B, 3pmn:A, 3pnc:A, 1rzt:A, 1rzt:M, 1rzt:E, 1rzt:I, 8u0o:A, 8u0p:A, 7un7:A, 3upq:A, 3uq0:A, 3uq2:A, 4x5v:A, 4xa5:A, 4xq8:B, 4xq8:A, 4xrh:B, 4xrh:A, 1xsl:A, 1xsl:E, 1xsl:I, 1xsl:M, 1xsn:A, 1xsp:A, 4xus:A
79 3fp2:A 483 185 0.0535 0.0890 0.2324 3.9 3fp4:A, 3lca:A
80 7zc6:D 304 70 0.0286 0.0757 0.3286 4.0
81 2xpi:A 520 50 0.0199 0.0308 0.3200 4.3 2xpi:D
82 7yeh:A 1020 199 0.0548 0.0431 0.2211 4.7 4ay5:A, 4ay5:B, 4ay5:C, 4ay5:D, 4ay6:A, 4ay6:B, 4ay6:C, 4ay6:D, 5c1d:A, 4cdr:A, 4cdr:B, 4cdr:C, 4cdr:D, 8cm9:A, 8cm9:B, 8cm9:D, 8cm9:C, 8fe7:A, 8fe7:C, 8fe7:E, 8fe7:G, 8fuf:A, 8fuf:C, 8fuf:E, 8fuf:G, 4gyw:C, 4gz3:C, 4gz5:A, 4gz5:B, 4gz5:C, 4gz5:D, 4gz6:A, 4gz6:B, 4gz6:C, 4gz6:D, 5hgv:C, 6ibo:A, 5lvv:A, 6ma1:A, 6ma2:A, 6ma3:A, 6ma4:A, 6ma5:A, 4n39:A, 4n3a:A, 4n3b:A, 4n3c:A, 5npr:A, 3pe3:A, 3pe3:B, 3pe3:C, 3pe3:D, 3pe4:A, 3pe4:C, 6q4m:A, 3tax:A, 3tax:C, 1w3b:A, 4xi9:A, 4xi9:B, 4xi9:C, 4xi9:D, 4xif:A, 4xif:B, 4xif:C, 4xif:D
83 7tra:A 572 76 0.0262 0.0367 0.2763 8.5
84 5j72:A 638 60 0.0212 0.0266 0.2833 9.2 5j72:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218