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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
VKLSVEPVTRVEGHGKISVSFDDSGNLDKVRFHVVEVRGFEKFLEGRYVEDAPIYTPRICGICQVAHHLASAKAVDNVFG
VKIPETAELLRNLMHQGATVHSHALHFYMLAAPDLMFPTTDDVLKRNLMGIAKEHPEIIKDAIELRKAGQNVVRVVGGRA
IHPVTAVVGGQSKSLKEEERDELLKLSERTIELSEKSIEVGKKLLENIKDEDLLDIGYFESAHMGMVNNGVHDLYDGKLR
VVNSEGKVEYEFDPSEYMNYIAEGVKPYSYLKFPYLKDKGEEDGIYRVNTLSRLNVSDKMATPLAQKYYDEFVKEFGKPC
HHPMLFHYARLIELLSSAEMVKELLENDKIVGEDIRAEPEEVVGDGVGCVEAPRGTLIHHFKTDDDGIITDTNLVVATVQ
NNPAMDIGVRKVAEKYIKAPEDATPQVLNYMEMLIRAYDPCLSCATH

The query sequence (length=447) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 5odc:F 447 447 1.0000 1.0000 1.0000 0.0 5odc:L, 5odh:F, 5odh:L, 5odi:F, 5odi:L, 5odq:F, 5odq:L, 5odr:F, 5odr:L
2 7t2r:D 447 448 0.4474 0.4474 0.4464 1.06e-136 7t2r:I, 7t30:D, 7t30:I
3 5xf9:D 455 450 0.4072 0.4000 0.4044 7.55e-121 5xf9:H, 5xfa:D, 5xfa:H
4 6rtp:B 484 494 0.3333 0.3079 0.3016 4.44e-44 5jsh:B, 5jsk:B, 5jsu:B, 5jsy:B, 5jt1:B, 6ru9:B, 6ruc:B, 2wpn:B, 6z7r:B, 6z7r:D, 6z8j:B, 6z8j:D, 6z8m:B, 6z8o:B, 6z8o:D, 6z9g:B, 6z9g:D, 6z9g:F, 6z9g:H, 6z9o:B, 6za1:B, 3ze6:B, 3ze7:B, 3ze8:B, 3ze9:B, 3zea:B
5 6qgr:A 437 463 0.2729 0.2792 0.2635 2.13e-43 6qgt:A, 6qii:A
6 4kl8:L 489 502 0.3378 0.3088 0.3008 3.77e-41 1cc1:L, 4kl8:M, 4kn9:L, 4kn9:M, 4ko1:L, 4ko1:M, 4ko2:L, 4ko2:M, 4ko3:L, 4ko3:M, 4ko4:L, 4ko4:M
7 4ci0:A 385 452 0.2864 0.3325 0.2832 7.32e-40 4omf:A
8 1frv:B 530 556 0.3423 0.2887 0.2752 3.93e-27 1frv:D, 2frv:L, 2frv:B, 2frv:D, 2frv:F, 2frv:H, 2frv:J, 1yq9:H, 1yq9:I
9 5a4f:L 581 275 0.1566 0.1205 0.2545 1.28e-21 5a4f:M, 5a4i:L, 5a4i:M, 5a4m:L, 5a4m:M, 5adu:L, 5adu:M, 6fpi:L, 6fpi:M, 6fpo:L, 6fpo:M, 6fpw:L, 6fpw:M, 6g7r:L, 6g7r:M, 6g94:L, 6g94:M, 6g94:J, 6g94:K, 6gal:L, 6gal:M, 4gd3:L, 4gd3:M, 4gd3:J, 4gd3:K, 5jrd:L, 5jrd:M, 5lmm:L, 5lmm:M, 5lry:L, 5lry:M, 6rp2:L, 6rp2:M, 4ue3:LLL, 4ue3:MMM, 3uqy:L, 3uqy:M, 3usc:L, 3usc:M, 3use:L, 3use:M
10 5a4f:L 581 88 0.0716 0.0551 0.3636 1.71e-04 5a4f:M, 5a4i:L, 5a4i:M, 5a4m:L, 5a4m:M, 5adu:L, 5adu:M, 6fpi:L, 6fpi:M, 6fpo:L, 6fpo:M, 6fpw:L, 6fpw:M, 6g7r:L, 6g7r:M, 6g94:L, 6g94:M, 6g94:J, 6g94:K, 6gal:L, 6gal:M, 4gd3:L, 4gd3:M, 4gd3:J, 4gd3:K, 5jrd:L, 5jrd:M, 5lmm:L, 5lmm:M, 5lry:L, 5lry:M, 6rp2:L, 6rp2:M, 4ue3:LLL, 4ue3:MMM, 3uqy:L, 3uqy:M, 3usc:L, 3usc:M, 3use:L, 3use:M
11 4iub:L 602 115 0.1029 0.0764 0.4000 1.29e-20 5d51:L, 4iuc:L, 4iud:L, 5mdj:L, 5mdk:L, 5mdl:L, 7odg:L, 7odh:L, 8pou:L, 8pov:L, 8pow:L, 8pox:L, 8poz:L, 3rgw:L, 4ttt:L
12 4iub:L 602 83 0.0626 0.0465 0.3373 2.00e-04 5d51:L, 4iuc:L, 4iud:L, 5mdj:L, 5mdk:L, 5mdl:L, 7odg:L, 7odh:L, 8pou:L, 8pov:L, 8pow:L, 8pox:L, 8poz:L, 3rgw:L, 4ttt:L
13 4c3o:A 583 115 0.1007 0.0772 0.3913 1.95e-20 4c3o:C, 4c3o:E
14 4c3o:A 583 112 0.0761 0.0583 0.3036 1.40e-05 4c3o:C, 4c3o:E
15 3ayx:A 595 117 0.0984 0.0739 0.3761 5.66e-20 3ayx:C, 3ayz:A, 3ayz:C, 5y34:A, 5y34:C
16 3ayx:A 595 132 0.0850 0.0639 0.2879 3.32e-04 3ayx:C, 3ayz:A, 3ayz:C, 5y34:A, 5y34:C
17 3myr:D 561 115 0.0962 0.0766 0.3739 9.13e-20 3myr:B, 3myr:F, 3myr:H
18 3myr:D 561 86 0.0716 0.0570 0.3721 1.95e-04 3myr:B, 3myr:F, 3myr:H
19 1h2a:L 534 114 0.1051 0.0880 0.4123 2.20e-19 1h2r:L, 4u9h:L, 4u9i:L, 1ubh:L, 1ubj:L, 1ubk:L, 1ubl:L, 1ubm:L, 1ubo:L, 1ubr:L, 1ubt:L, 1ubu:L, 8w6x:L, 1wuh:L, 1wui:L, 1wuj:L, 1wuk:L, 1wul:L, 5xle:L, 5xlf:L, 5xlg:L, 5xlh:L, 5y4n:L
20 1h2a:L 534 126 0.0917 0.0768 0.3254 3.33e-05 1h2r:L, 4u9h:L, 4u9i:L, 1ubh:L, 1ubj:L, 1ubk:L, 1ubl:L, 1ubm:L, 1ubo:L, 1ubr:L, 1ubt:L, 1ubu:L, 8w6x:L, 1wuh:L, 1wui:L, 1wuj:L, 1wuk:L, 1wul:L, 5xle:L, 5xlf:L, 5xlg:L, 5xlh:L, 5y4n:L
21 6ehq:L 551 115 0.0850 0.0690 0.3304 8.78e-18 6ehq:M, 6ehs:L, 6ehs:M, 6en9:L, 6en9:M, 6g7m:L, 6g7m:M, 6gam:L, 6gam:M, 6gan:L, 6gan:M, 7nem:L, 7nem:M, 6syo:LLL, 6syo:MMM, 6syx:LLL, 6syx:MMM, 6szd:LLL, 6szd:MMM, 6szk:LLL, 6szk:MMM, 7vxq:A, 7vxq:C, 5xvb:L, 5xvb:M, 5xvc:L, 5xvc:M, 5xvd:L, 5xvd:M
22 6ehq:L 551 84 0.0604 0.0490 0.3214 1.29e-04 6ehq:M, 6ehs:L, 6ehs:M, 6en9:L, 6en9:M, 6g7m:L, 6g7m:M, 6gam:L, 6gam:M, 6gan:L, 6gan:M, 7nem:L, 7nem:M, 6syo:LLL, 6syo:MMM, 6syx:LLL, 6syx:MMM, 6szd:LLL, 6szd:MMM, 6szk:LLL, 6szk:MMM, 7vxq:A, 7vxq:C, 5xvb:L, 5xvb:M, 5xvc:L, 5xvc:M, 5xvd:L, 5xvd:M
23 3cur:H 545 112 0.0962 0.0789 0.3839 1.83e-17 3cur:I, 3cur:J, 3cus:Q, 3cus:R, 3cus:S, 1frf:L, 3h3x:Q, 3h3x:R, 3h3x:S, 4ucq:Q, 4ucq:R, 4ucq:S, 4ucw:Q, 4ucw:R, 4ucw:S, 4ucx:Q, 4ucx:R, 4ucx:S, 4ud2:S, 4ud2:Q, 4ud2:R, 4ud6:Q, 4ud6:R, 4ud6:S, 4ue2:Q, 4ue2:R, 4ue2:S, 4ue6:R, 4ue6:Q, 4ue6:S, 4ueq:Q, 4ueq:R, 4ueq:S, 4ueq:T, 4ueq:U, 4ueq:V, 4uew:Q, 4uew:R, 4uew:S, 4upe:Q, 4upe:R, 4upe:S, 4upv:Q, 4upv:R, 4uql:Q, 4uql:R, 4uqp:Q, 4uqp:R, 4urh:Q, 4urh:S, 4urh:R, 1yqw:Q, 1yqw:R, 1yqw:S, 1yrq:H, 1yrq:I, 1yrq:J, 1yrq:K, 1yrq:M, 1yrq:N
24 3cur:H 545 190 0.1186 0.0972 0.2789 2.42e-05 3cur:I, 3cur:J, 3cus:Q, 3cus:R, 3cus:S, 1frf:L, 3h3x:Q, 3h3x:R, 3h3x:S, 4ucq:Q, 4ucq:R, 4ucq:S, 4ucw:Q, 4ucw:R, 4ucw:S, 4ucx:Q, 4ucx:R, 4ucx:S, 4ud2:S, 4ud2:Q, 4ud2:R, 4ud6:Q, 4ud6:R, 4ud6:S, 4ue2:Q, 4ue2:R, 4ue2:S, 4ue6:R, 4ue6:Q, 4ue6:S, 4ueq:Q, 4ueq:R, 4ueq:S, 4ueq:T, 4ueq:U, 4ueq:V, 4uew:Q, 4uew:R, 4uew:S, 4upe:Q, 4upe:R, 4upe:S, 4upv:Q, 4upv:R, 4uql:Q, 4uql:R, 4uqp:Q, 4uqp:R, 4urh:Q, 4urh:S, 4urh:R, 1yqw:Q, 1yqw:R, 1yqw:S, 1yrq:H, 1yrq:I, 1yrq:J, 1yrq:K, 1yrq:M, 1yrq:N
25 1e3d:B 537 112 0.0940 0.0782 0.3750 2.97e-16 1e3d:D
26 1e3d:B 537 127 0.1007 0.0838 0.3543 6.50e-07 1e3d:D
27 8dqv:A 513 175 0.1208 0.1053 0.3086 4.10e-14 8dqv:C, 7utd:A, 7utd:C, 7utd:E, 7utd:G, 7utd:I, 7utd:K, 7utd:M, 7utd:O, 7uur:C, 7uur:F, 7uus:A, 7uus:C, 7uus:E, 7uus:G, 7uus:I, 7uus:K, 7uus:M, 7uus:O
28 8dqv:A 513 243 0.1253 0.1092 0.2305 0.73 8dqv:C, 7utd:A, 7utd:C, 7utd:E, 7utd:G, 7utd:I, 7utd:K, 7utd:M, 7utd:O, 7uur:C, 7uur:F, 7uus:A, 7uus:C, 7uus:E, 7uus:G, 7uus:I, 7uus:K, 7uus:M, 7uus:O
29 7z0s:E 532 96 0.0694 0.0583 0.3229 5.35e-09 7z0t:E
30 5aa5:G 561 106 0.0671 0.0535 0.2830 8.49e-07 5aa5:C, 5aa5:E, 5aa5:K, 5aa5:I, 5aa5:L
31 5aa5:G 561 126 0.0761 0.0606 0.2698 0.026 5aa5:C, 5aa5:E, 5aa5:K, 5aa5:I, 5aa5:L
32 6cfw:L 374 129 0.0738 0.0882 0.2558 5.24e-06
33 6cfw:L 374 93 0.0559 0.0668 0.2688 6.5
34 6i0d:4 384 150 0.0984 0.1146 0.2933 1.03e-05 6i0d:E, 6i1p:E, 3i9v:4, 3iam:4, 3ias:4, 3ias:D, 3ias:M, 3ias:V, 3m9s:4, 3m9s:D, 6q8o:4, 6q8o:E, 6q8w:4, 6q8w:E, 6q8x:4, 6q8x:E, 2ybb:4
35 3qvk:A 245 112 0.0716 0.1306 0.2857 0.062 3qvk:B, 3qvl:A, 3qvl:B
36 6o6c:B 1165 62 0.0425 0.0163 0.3065 0.90 5c44:B, 2e2h:B, 9ja1:B, 2nvz:B, 6upy:B, 2yu9:B
37 8tvy:B 1207 62 0.0425 0.0157 0.3065 0.92 3gtg:B, 3gtj:B, 3gtk:B, 8jch:B, 8k5p:B, 7o4k:B, 7o4l:B, 5u5q:B, 5vvr:B, 5vvs:B
38 5c4j:B 1157 62 0.0425 0.0164 0.3065 0.96 4a3b:B, 4a3c:B, 4a3d:B, 4a3e:B, 4a3f:B, 4a3g:B, 4a3i:B, 4a3j:B, 4a3k:B, 4a3l:B, 4a3m:B, 4a93:B, 2b63:B, 2b8k:B, 6blo:B, 6blp:B, 6bm2:B, 6bm4:B, 6bqf:B, 4by1:B, 4by7:B, 2e2j:B, 3gtl:B, 3gtm:B, 3gto:B, 3gtp:B, 3gtq:B, 3h3v:C, 3hou:B, 3hou:N, 3hov:B, 3how:B, 3hox:B, 3hoy:B, 3hoz:B, 6i84:B, 3j0k:B, 2ja5:B, 2ja6:B, 2ja7:B, 2ja7:N, 2ja8:B, 7ked:B, 7kee:B, 7kef:B, 3m3y:B, 3m4o:B, 7ml4:B, 7nkx:B, 7nky:B, 2nvq:B, 2nvt:B, 2nvx:B, 5ot2:B, 3po3:B, 3qt1:B, 2r7z:B, 1r9t:B, 2r92:B, 2r93:B, 7riq:B, 7riw:B, 7rix:B, 7riy:B, 3rzd:B, 3rzo:B, 3s14:B, 3s15:B, 3s16:B, 3s17:B, 3s1m:B, 3s1n:B, 3s1q:B, 3s1r:B, 3s2d:B, 3s2h:B, 1sfo:B, 8ukq:B, 8ukr:B, 8uks:B, 8ukt:B, 8uku:B, 6upx:B, 6upz:B, 6uq0:B, 6uq1:B, 6uq2:B, 6uq3:B, 2vum:B, 4x67:B, 4x6a:B, 1y1v:B, 1y1w:B, 4y52:B, 1y77:B, 4y7n:B
39 3k7a:B 1122 62 0.0425 0.0169 0.3065 0.96
40 8tug:B 1041 62 0.0425 0.0183 0.3065 0.98 8tvp:B, 8tvq:B, 8tvs:B, 8tvv:B, 8tvw:B, 8tvx:B
41 8qby:D 410 69 0.0447 0.0488 0.2899 1.00
42 8qby:D 410 146 0.0895 0.0976 0.2740 6.3
43 8cen:B 1180 62 0.0425 0.0161 0.3065 1.0 4bbr:B, 4bbs:B, 5c3e:B, 5c4a:B, 5c4x:B, 8ceo:B, 2e2i:B, 3fki:B, 5fmf:B, 5fyw:B, 5fz5:B, 6gyk:B, 6gyl:B, 6gym:B, 3i4m:B, 3i4n:B, 5ip7:B, 5ip9:B, 3k1f:B, 7mei:b, 7mei:B, 7mk9:B, 7mka:b, 7ml0:B, 7ml1:B, 7ml2:B, 7o4i:B, 7o4j:B, 7o72:B, 7o73:B, 7o75:B, 5oqj:B, 5oqm:B, 3po2:B, 7rim:B, 7rip:B, 5sva:B, 4v1m:B, 4v1n:B, 4v1o:B, 7zs9:B, 7zsa:B, 7zsb:B
44 4bxx:B 1097 62 0.0425 0.0173 0.3065 1.0 4bxz:B, 3cqz:B, 1i3q:B, 1i50:B, 1i6h:B, 1k83:B, 1nik:B, 2nvy:B, 1r5u:B, 1r9s:B, 1twa:B, 1twc:B, 1twf:B, 1twg:B, 1twh:B, 5w4u:B, 5w51:B, 1wcm:B
45 8u9r:B 1060 62 0.0425 0.0179 0.3065 1.0 8u9x:B
46 4by9:F 366 68 0.0470 0.0574 0.3088 2.3 4by9:I, 4by9:C, 4by9:L, 3nmu:A, 3nmu:B, 3nvi:A, 3nvi:C, 3nvk:A, 3nvk:F
47 7xn7:B 1164 62 0.0403 0.0155 0.2903 3.6 6a5l:B, 6a5o:B, 6a5p:B, 6a5r:B, 6a5t:B, 6a5u:B, 8h0v:B, 8h0w:B, 8he5:B, 6inq:B, 6ir9:B, 6j4w:B, 6j4x:B, 6j4y:B, 6j4z:B, 6j50:B, 6j51:B, 8jh2:B, 8jh3:B, 8jh4:B, 7wbv:B, 7wbw:B, 7wbx:B, 5xog:B, 5xon:B, 7xse:B, 7xsx:B, 7xsz:B, 7xt7:B, 7xtd:B, 7xti:B, 8yfq:B, 8yfr:B
48 6hiv:BM 245 46 0.0358 0.0653 0.3478 3.7 6hix:BM
49 1l6j:A 405 48 0.0268 0.0296 0.2500 4.2
50 7p63:C 589 153 0.0716 0.0543 0.2092 4.2 7nyr:D, 7nyu:D, 7nz1:D, 7p64:C, 7p69:C, 7p7c:C, 7p7j:C, 7p7l:C, 7p7m:C, 7z7r:C, 7z7s:C, 7z7t:C, 7z7v:C, 7z80:C, 7z83:C, 7z84:C, 7zc5:C, 7zci:C
51 6i7v:D7 68 59 0.0380 0.2500 0.2881 4.5
52 7p7k:C 568 96 0.0537 0.0423 0.2500 5.3 7p7e:C
53 6fg5:A 334 72 0.0425 0.0569 0.2639 5.3 6ezu:A, 6ezu:B, 6fg5:B
54 4bq8:C 161 67 0.0425 0.1180 0.2836 5.4 4bq6:D, 4bq6:F, 4bq7:D, 4bq7:F, 7ndg:F, 7ndg:C, 7ndg:I, 7ne0:D, 6z3m:c, 6z3m:d, 6z3m:i, 6z3m:j, 6z3m:o, 6z3m:p
55 3nb0:C 646 38 0.0268 0.0186 0.3158 5.9 4kq1:A, 4kq1:B, 4kq1:C, 4kq1:D, 4kq2:A, 4kq2:B, 4kq2:C, 4kq2:D, 4kqm:A, 4kqm:B, 4kqm:C, 4kqm:D, 3nb0:A, 3nb0:B, 3nb0:D, 3rt1:A, 3rt1:C, 3rt1:D, 3rt1:B, 5suk:A, 5suk:B, 5suk:C, 5suk:D, 5sul:A, 5sul:B, 6u77:A, 6u77:B, 6u77:C, 6u77:D, 5uw0:A, 5uw0:B, 5uw0:C, 5uw0:D, 5uw1:A, 5uw1:B, 5uw1:C, 5uw1:D, 5uw4:C, 5uw4:B, 5uw4:A, 5uw4:D, 5ux7:A, 5ux7:B, 5ux7:C, 5ux7:D, 5vnc:A, 5vnc:B, 5vnc:C, 5vnc:D
56 7aor:z 1071 39 0.0291 0.0121 0.3333 6.2
57 8ok9:C 236 87 0.0515 0.0975 0.2644 6.3 8pvv:C, 8qg0:B
58 4g8b:A 277 66 0.0313 0.0505 0.2121 7.2 4g8b:B, 4g8c:A, 4g8c:B, 4g9e:A, 4g9e:B
59 6c66:B 334 62 0.0447 0.0599 0.3226 7.7
60 2d1f:A 349 118 0.0626 0.0802 0.2373 8.3 2d1f:B
61 6q9v:B 145 37 0.0291 0.0897 0.3514 9.0 6q9v:A, 6qa0:A, 6qa0:B
62 8k32:C 333 63 0.0425 0.0571 0.3016 9.4 8k32:A, 8k32:B, 8k32:D
63 3sgi:A 408 51 0.0336 0.0368 0.2941 9.4 7k72:A, 7k72:B, 7k72:C, 7k72:D, 6kdu:A, 6kjm:A, 6kkv:A, 6krh:A, 6ksc:A, 6ksd:A, 6lw8:A, 1zau:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218