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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
TVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAK
KNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVG

The query sequence (length=123) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6fec:s 131 123 0.9919 0.9313 0.9919 1.18e-86 7a01:I5, 7a09:z, 5a2q:Y, 5aj0:BY, 9bdl:AS24, 9bdn:AS24, 9bdp:AS24, 8bhf:Z3, 9bkd:T, 9bln:T, 8btk:Ax, 7cpu:SY, 7cpv:SY, 4d5l:Y, 4d61:Y, 6d90:ZZ, 6d9j:ZZ, 9f1b:Ax, 9f1c:Ax, 9f1d:Ax, 5flx:Y, 6g18:Y, 6g4s:Y, 6g4w:Y, 6g51:Y, 6g53:Y, 6g5h:Y, 6g5i:Y, 8g5y:SY, 8g5z:SY, 8g60:SY, 8g61:SY, 8g6j:SY, 8glp:SY, 6gz3:BY, 6gz4:BY, 6gz5:BY, 6hcf:Z1, 6hcj:Z2, 6hcm:Z1, 6hcq:Z2, 8ifd:3N, 8ife:3N, 6ip5:3N, 6ip6:3N, 6ip8:3N, 3j7p:SY, 3j7r:SY, 3jag:YY, 3jah:YY, 3jai:YY, 3jaj:SY, 3jan:SY, 8jdj:AK, 8jdk:AK, 8jdl:AK, 8jdm:AK, 7jqb:Z, 7jqc:Z, 5k0y:s, 8k2c:SY, 7k5i:Y, 4kzx:Y, 4kzy:Y, 4kzz:Y, 5lks:SY, 7ls1:Q3, 7ls2:Q3, 5lzs:YY, 5lzt:YY, 5lzu:YY, 5lzv:YY, 5lzw:YY, 5lzx:YY, 5lzy:YY, 5lzz:YY, 7mdz:YY, 7mq8:LF, 7mq9:LF, 7mqa:LF, 6mtb:YY, 6mtc:YY, 6mtd:YY, 6mte:YY, 7nwg:Z2, 7nwh:YY, 7nwi:YY, 7o7y:Ax, 7o7z:Ax, 7o80:Ax, 7o81:Ax, 5oa3:Y, 6ole:SY, 6olf:SY, 6olg:BY, 6oli:SY, 6olz:BY, 6om0:SY, 6om7:SY, 7oya:Y2, 7oyb:Y2, 7oyc:Y2, 7oyd:YY, 8oz0:e, 8p03:a, 8p09:a, 8p2k:Ax, 6p4g:Z, 6p4h:Z, 6p5i:Z, 6p5j:Z, 6p5k:Z, 6p5n:Z, 8pj1:T, 8pj2:T, 8pj3:T, 8pj4:T, 8pj5:T, 8pj6:T, 8ppk:Y, 8ppl:AY, 8q7z:Ax, 8q87:Ax, 7qgg:SY, 8qoi:SY, 7qp6:T, 7qp7:T, 7qvp:SY, 7qvp:RY, 6qzp:SY, 7r4x:Y, 6r5q:NN, 6r6g:NN, 6r6p:NN, 6r7q:NN, 8scb:YY, 6sgc:Z1, 7syg:Z, 7syh:Z, 7syi:Z, 7syj:Z, 7syk:Z, 7syl:Z, 7sym:Z, 7syn:Z, 7syo:Z, 7syp:Z, 7syq:Z, 7syr:Z, 7sys:Z, 7syt:Z, 7syu:Z, 7syv:Z, 7syw:Z, 7syx:Z, 5t2c:AQ, 8t4s:Y, 7toq:AS24, 7tor:AS24, 7tql:Y, 7ucj:YY, 7uck:YY, 4ug0:SY, 4ujc:CY, 4ujd:CY, 4uje:BY, 4v6x:AY, 5vyc:Y1, 5vyc:Y2, 5vyc:Y3, 5vyc:Y4, 5vyc:Y5, 5vyc:Y6, 6w2s:Z, 6w2t:Z, 7wts:Y, 7wtt:Y, 7wtu:Y, 7wtv:Y, 7wtw:Y, 7wtx:Y, 7wtz:Y, 7wu0:Y, 6xa1:SY, 7xnx:SY, 7xny:SY, 8xsx:SY, 8xsy:SY, 8xsz:SY, 8xxl:SY, 8xxm:SY, 8xxn:SY, 6y0g:SY, 8y0w:SY, 8y0x:SY, 6y2l:SY, 6y57:SY, 6yal:a, 6yam:a, 6yan:a, 6ybw:T, 8yoo:SY, 8yop:SY, 6z6l:SY, 6z6m:SY, 6z6n:SY, 7zjw:Sj, 7zjx:Sj, 6zlw:Y, 6zm7:SY, 6zme:SY, 6zmi:SY, 6zmo:SY, 6zmt:Y, 6zmw:T, 6zn5:Y, 6zoj:Y, 6zok:Y, 6zon:z, 6zp4:z, 6zuo:Y, 6zv6:Y, 6zvh:Y, 6zvj:z, 6zvk:I5, 6zxd:Y, 6zxe:Y, 6zxf:Y, 6zxg:Y, 6zxh:Y
2 4v6w:AY 126 123 0.7805 0.7619 0.7805 1.32e-69 6xu6:AY, 6xu7:AY, 6xu8:AY
3 8auv:H 127 124 0.6911 0.6693 0.6855 6.32e-56 8b2l:H1, 7qix:U, 7qiz:KA
4 9bh5:AY 123 123 0.6585 0.6585 0.6585 4.51e-55 9cai:AY
5 4v7e:BY 138 124 0.6585 0.5870 0.6532 9.62e-54 8ip8:ba, 8ip9:ba, 8ipa:ba, 8ipb:ba, 8jiw:BY, 4v3p:SU
6 7a1g:d 134 120 0.5935 0.5448 0.6083 8.50e-48 7ajt:DY, 7aju:DY, 7b7d:d, 8bn3:D4, 8bqd:d, 8bqx:d, 8c00:d, 8c01:d, 8c83:d, 8cah:d, 8cas:d, 8cbj:Y, 8ccs:0, 8cdl:0, 8cdr:0, 8ceh:0, 8cf5:0, 8cg8:0, 8cgn:0, 8civ:0, 8cku:0, 8cmj:0, 7d4i:SZ, 7d5t:SZ, 7d63:SZ, 5dat:D4, 5dat:d4, 5dc3:D4, 5dc3:d4, 5dge:D4, 5dge:d4, 5dgf:D4, 5dgf:d4, 5dgv:D4, 5dgv:d4, 6eml:d, 8eub:BY, 8evp:BY, 8evq:BY, 8evr:BY, 8evs:BY, 8evt:BY, 8ewb:BY, 8ewc:BY, 6fai:Y, 5fci:D4, 5fci:d4, 5fcj:D4, 5fcj:d4, 6fyx:Y, 6fyy:Y, 6gq1:AO, 6gqb:AO, 6gqv:AO, 6gsm:Y, 6gsn:Y, 6hhq:Z, 6hhq:d4, 5i4l:D4, 5i4l:d4, 6i7o:d, 6i7o:db, 8i7j:Y, 5it7:Y, 5it9:Y, 3j16:D, 3j6x:24, 3j6y:24, 3j77:24, 3j78:24, 3j80:Y, 3j81:Y, 3jam:Y, 3jap:Y, 5juo:VB, 5jup:VB, 5jus:VB, 5jut:VB, 5juu:VB, 8k2d:SY, 8k82:SY, 6ke6:SZ, 5ll6:d, 6lqp:SZ, 6lqq:SZ, 6lqr:SZ, 6lqs:SZ, 6lqt:SZ, 6lqu:SZ, 6lqv:SZ, 5lyb:D4, 5lyb:d4, 5m1j:Y2, 5mc6:d, 5mei:d4, 5mei:Z, 7mpi:BY, 7mpj:BY, 7n8b:BY, 5ndg:D4, 5ndg:d4, 5ndv:D4, 5ndv:d4, 5ndw:D4, 5ndw:d4, 7nrc:Sd, 7nrd:Sd, 5obm:D4, 5obm:d4, 5on6:d4, 5on6:Z, 7osa:eS24, 7osm:eS24, 6q8y:d, 6rbd:Y, 6rbe:Y, 7rr5:SY, 8rw1:Y, 6s47:BZ, 8s8d:Y, 8s8e:Y, 8s8f:Y, 8s8g:Y, 8s8h:Y, 8s8i:Y, 8s8j:Y, 6snt:Y, 7suk:LF, 6sv4:d, 6sv4:db, 6sv4:dc, 6t4q:SY, 6t7i:SY, 6t7t:SY, 6t83:Yb, 6t83:z, 5tbw:Z, 5tbw:d4, 6tb3:d, 5tga:D4, 5tga:d4, 5tgm:D4, 5tgm:d4, 6tnu:d, 4u3m:D4, 4u3m:d4, 4u3n:D4, 4u3n:d4, 4u3u:D4, 4u3u:d4, 4u4n:D4, 4u4n:d4, 4u4o:D4, 4u4o:d4, 4u4q:D4, 4u4q:d4, 4u4r:D4, 4u4r:d4, 4u4u:D4, 4u4u:d4, 4u4y:D4, 4u4y:d4, 4u4z:D4, 4u4z:d4, 4u50:D4, 4u50:d4, 4u51:D4, 4u51:d4, 4u52:D4, 4u52:d4, 4u53:D4, 4u53:d4, 4u55:D4, 4u55:d4, 4u56:D4, 4u56:d4, 4u6f:D4, 4u6f:d4, 4uer:P, 6uz7:Y, 4v6i:AU, 4v88:AY, 4v88:CY, 4v8y:AY, 4v8z:AY, 4v92:BY, 6wdr:Y, 5wlc:LF, 6woo:YY, 7wtl:SY, 7wtm:SY, 7wtn:SY, 7wto:SY, 7wtp:SY, 7wtq:SY, 7wtr:SY, 5wyj:SZ, 5wyk:SZ, 6xiq:AO, 6xir:AO, 8y0u:SY, 6y7c:Y, 6z6j:SY, 6z6k:SY, 6zce:Z, 7zpq:AY, 6zqb:DY, 6zqc:DY, 6zqd:DY, 6zqe:DY, 6zqf:DY, 6zqg:DY, 7zrs:AY, 6zu9:d, 7zuw:AY, 7zux:DY, 6zvi:I, 7zw0:sd
7 8c3a:a 134 118 0.5935 0.5448 0.6186 2.83e-47 8c3a:DL, 8cq7:a, 8cq7:DL, 8cqw:a, 8cqw:DL, 8cre:a, 8cre:DL, 8oeq:a, 8oeq:DL, 7pzy:Z, 7q08:Z, 7q0f:Z, 7q0p:Z, 7q0r:Z, 8q5i:Z
8 7olc:SY 132 117 0.5854 0.5455 0.6154 4.13e-47 7old:SY, 8oo0:SY, 5oql:y, 6rxu:Co, 6rxv:Co, 6rxx:Co, 6rxz:Co, 7z3n:SY, 7z3o:SY
9 7r81:Z2 124 120 0.5935 0.5887 0.6083 1.94e-46
10 8r6f:Y 124 120 0.6341 0.6290 0.6500 6.47e-43
11 3j7a:1 120 117 0.5203 0.5333 0.5470 3.09e-38 3jbn:1, 3jbo:1, 3jbp:1, 6okk:a, 8tpu:S1
12 6zj3:SZ 127 118 0.5447 0.5276 0.5678 1.24e-35
13 5xxu:Y 128 124 0.4959 0.4766 0.4919 9.06e-33
14 4bts:AP 148 118 0.4146 0.3446 0.4322 2.06e-30 4bts:BP, 4bts:CP, 4bts:DP, 5jpq:0, 4v5o:AP, 4v5o:BP
15 8fvy:Y 122 120 0.4553 0.4590 0.4667 6.75e-27 8br8:Sb, 8brm:Sb, 8bsi:Sb, 8bsj:Sb, 8btd:Sb, 8btr:Sb, 8g4s:Y, 7pwf:Y, 7pwo:Y1
16 4v8m:AT 131 120 0.5447 0.5115 0.5583 1.27e-22 7ase:y, 5opt:Y, 8ova:AT, 8ove:AT
17 5xyi:Y 105 102 0.3984 0.4667 0.4804 2.08e-20
18 8rxh:SZ 130 121 0.5122 0.4846 0.5207 1.73e-18 8a3w:SZ, 8a98:SZ, 6az1:Z, 8ovj:SZ, 8rxx:SZ, 5t2a:AT
19 7qep:D4 127 108 0.3089 0.2992 0.3519 1.97e-14
20 6tmf:X 97 95 0.2439 0.3093 0.3158 3.49e-14
21 5jb3:V 99 97 0.2439 0.3030 0.3093 1.97e-13 5jbh:V, 6sw9:V, 6swc:V, 6swd:V, 4v4n:BV, 4v6u:AV, 4v6u:B6, 7zag:V, 7zah:V, 7zai:V, 7zhg:V
22 6skf:Aw 95 93 0.2276 0.2947 0.3011 4.38e-11 6skg:Aw, 6skg:Bn, 6th6:Aw
23 8p5d:SY0 136 116 0.2764 0.2500 0.2931 4.48e-09 8p60:SY0, 8p60:RY0, 7qca:SY0
24 8hkx:S24E 96 81 0.1626 0.2083 0.2469 1.46e-05 8hky:S24E, 8hkz:S24E, 8hl1:S24E, 8hl2:S24E, 8hl3:S24E, 8hl4:S24E, 8hl5:S24E, 8wkp:S24E, 8wq2:S24E, 8wq4:S24E
25 6zu5:SY0 123 72 0.1707 0.1707 0.2917 5.75e-05
26 6rm3:SY0 125 79 0.1870 0.1840 0.2911 1.77e-04
27 3ga9:S 167 98 0.2358 0.1737 0.2959 0.53 3g9k:S
28 8cem:B 974 47 0.1220 0.0154 0.3191 1.1
29 3f1t:B 137 36 0.1138 0.1022 0.3889 1.5 3f1t:A, 3f1t:D, 3f1t:C
30 5zm5:A 398 18 0.0894 0.0276 0.6111 5.7 5zm6:A, 5zm6:B, 5zm7:A
31 3g1p:B 250 33 0.0976 0.0480 0.3636 7.1 3g1p:A, 3p2u:A, 3p2u:B
32 3k8k:A 650 44 0.1220 0.0231 0.3409 9.1 6bs6:A, 6bs6:B, 3k8k:B, 3k8l:A, 3k8l:B, 3k8m:A, 3k8m:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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