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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
TTIVSVRRNGQVVVGGDGQVSLGNTVMKGNARKVRRLYNGKVLAGFAGGTADAFTLFELFERKLEMHQGHLLKSAVELAK
DWRTDRALRKLEAMLIVADEKESLIITGIGDVVQPEEDQILAIGSGGNYALSAARALVENTELSAHEIVEKSLRIAGDIC
VFTNTNFTIEELP

The query sequence (length=173) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 1jjw:A 173 173 1.0000 1.0000 1.0000 1.84e-125 1jjw:B, 1jjw:C, 1kyi:G, 1kyi:H, 1kyi:I, 1kyi:J, 1kyi:K, 1kyi:L, 1kyi:M, 1kyi:N, 1kyi:O, 1kyi:P, 1kyi:Q, 1kyi:R, 1ofh:G, 1ofh:H, 1ofh:I, 1ofh:L, 1ofh:M, 1ofh:N, 1ofi:G, 1ofi:H, 1ofi:I, 1ofi:L, 1ofi:M, 1ofi:N
2 5ji2:A 174 172 0.7977 0.7931 0.8023 4.92e-97 5ji2:D
3 4hnz:A 174 173 0.5145 0.5115 0.5145 3.75e-50 4hnz:B, 4hnz:C, 4hnz:D, 4hnz:E, 4hnz:F, 4hnz:G, 4hnz:H, 4hnz:I, 4hnz:J, 4hnz:K, 4hnz:L, 4ho7:A, 4ho7:B, 4ho7:C
4 7awe:H 199 140 0.2370 0.2060 0.2929 7.38e-04 7awe:V, 7b12:H, 7b12:V, 6e5b:N, 6e5b:b, 3unf:N, 3unf:b, 8ysx:F, 8ysx:A, 8yvg:F, 8yvg:A
5 5fg9:V 230 67 0.1272 0.0957 0.3284 0.002 5ahj:H, 5ahj:V, 3bdm:H, 3bdm:V, 5bou:H, 5bou:V, 8bw1:H, 8bw1:V, 5bxl:H, 5bxl:V, 5bxn:H, 5bxn:V, 5cgf:V, 5cgg:V, 5cgh:V, 5cgi:H, 5cgi:V, 5cz4:V, 5cz5:H, 5cz5:V, 5cz6:H, 5cz6:V, 5cz7:H, 5cz7:V, 5cz8:H, 5cz8:V, 5cz9:H, 5cz9:V, 5cza:V, 5d0s:H, 5d0s:V, 5d0t:V, 5d0v:H, 5d0v:V, 5d0w:V, 5d0x:H, 5d0x:V, 5d0z:H, 5d0z:V, 3d29:H, 3d29:V, 5dki:H, 5dki:V, 5dkj:H, 5dkj:V, 3dy4:H, 3dy4:V, 6ef3:2, 4eu2:I, 4eu2:W, 2f16:H, 2f16:V, 2fak:H, 2fak:V, 5fg7:V, 5fga:V, 5fgd:H, 5fgd:V, 5fge:H, 5fge:V, 5fgf:H, 5fgf:V, 5fgg:H, 5fgg:V, 5fgh:H, 5fgh:V, 5fhs:H, 5fhs:V, 1fnt:I, 1fnt:W, 9fsv:H, 9fsv:V, 9ft0:H, 9ft0:V, 9ft1:H, 9ft1:V, 4fzc:H, 4fzc:V, 4fzg:H, 4fzg:V, 1g0u:H, 1g0u:V, 4g4s:I, 1g65:H, 6g7f:H, 6g7f:V, 6g8m:H, 6g8m:V, 6g8n:H, 6g8n:V, 4gk7:H, 4gk7:V, 6gop:H, 6gop:V, 2gpl:H, 2gpl:V, 3gpj:H, 3gpj:V, 3gpt:H, 3gpt:V, 3gpw:H, 3gpw:V, 6h39:V, 4hnp:H, 4hnp:V, 4hrc:H, 4hrc:V, 4hrd:H, 4hrd:V, 6hv3:V, 6hv4:H, 6hv4:V, 6hv5:H, 6hv5:V, 6hv7:H, 6hv7:V, 6hva:H, 6hva:V, 6hvr:H, 6hvr:V, 6hvs:H, 6hvs:V, 6hvt:H, 6hvt:V, 6hvu:H, 6hvu:V, 6hvv:H, 6hvv:V, 6hvw:H, 6hvw:V, 6hvx:H, 6hvx:V, 6hvy:H, 6hvy:V, 6hw0:H, 6hw0:V, 6hw3:H, 6hw3:V, 6hw4:H, 6hw4:V, 6hw5:H, 6hw5:V, 6hw6:H, 6hw6:V, 6hw7:H, 6hw7:V, 6hw8:H, 6hw8:V, 6hw9:H, 6hw9:V, 6hwa:V, 6hwb:H, 6hwb:V, 6hwc:V, 6hwd:H, 6hwd:V, 6hwe:H, 6hwe:V, 6hwf:H, 6hwf:V, 3hye:H, 3hye:V, 4inr:H, 4inr:V, 4int:H, 4int:V, 4inu:H, 4inu:V, 1jd2:H, 1jd2:O, 5jhr:V, 5jhs:H, 5jhs:V, 4jsu:H, 4jsu:V, 5l52:V, 5l54:V, 5l55:V, 5l5a:V, 5l5b:V, 5l5d:H, 5l5d:V, 5l5e:H, 5l5e:V, 5l5f:H, 5l5f:V, 5l5h:V, 5l5i:V, 5l5j:H, 5l5j:V, 5l5o:H, 5l5o:V, 5l5p:H, 5l5p:V, 5l5q:V, 5l5r:V, 5l5s:V, 5l5t:V, 5l5u:H, 5l5u:V, 5l5v:V, 5l5w:V, 5l5x:H, 5l5x:V, 5l5y:H, 5l5y:V, 5l5z:H, 5l5z:V, 5l60:V, 5l61:V, 5l62:V, 5l63:H, 5l63:V, 5l64:V, 5l65:H, 5l65:V, 5l66:H, 5l66:V, 5l67:V, 5l68:H, 5l68:V, 5l69:H, 5l69:V, 5l6a:H, 5l6a:V, 5l6b:H, 5l6b:V, 5l6c:V, 5lai:V, 5laj:V, 5ltt:V, 5m2b:V, 3mg0:H, 3mg0:V, 3mg4:H, 3mg6:H, 3mg7:H, 3mg8:H, 4nnn:H, 4nnn:V, 4nnw:H, 4nnw:V, 4no1:V, 4no6:V, 4no8:V, 4no9:H, 4no9:V, 7o2l:H, 7o2l:V, 3oeu:H, 3oev:H, 8ohz:H, 8ohz:V, 8oi1:H, 8oi1:V, 8olr:H, 8olr:V, 4q1s:H, 4q1s:V, 4qby:H, 4qby:V, 4qlq:H, 4qlq:V, 4qls:V, 4qlt:V, 4qlu:V, 4qlv:V, 4qux:V, 4qv0:V, 4qv1:V, 4qv3:V, 4qv4:V, 4qv5:V, 4qv6:V, 4qv7:V, 4qv8:V, 4qv9:V, 4qvl:H, 4qvl:V, 4qvm:H, 4qvm:V, 4qvn:H, 4qvn:V, 4qvp:H, 4qvp:V, 4qvq:H, 4qvq:V, 4qvv:H, 4qvv:V, 4qvw:H, 4qvw:V, 4qvy:H, 4qvy:V, 4qw0:H, 4qw0:V, 4qw1:H, 4qw1:V, 4qw3:H, 4qw3:V, 4qw4:H, 4qw4:V, 4qw5:H, 4qw5:V, 4qw6:H, 4qw6:V, 4qw7:H, 4qw7:V, 4qwf:H, 4qwf:V, 4qwg:H, 4qwg:V, 4qwi:H, 4qwi:V, 4qwj:H, 4qwj:V, 4qwk:H, 4qwk:V, 4qwl:H, 4qwl:V, 4qwr:H, 4qwr:V, 4qws:H, 4qws:V, 4qwu:H, 4qwu:V, 4qwx:H, 4qwx:V, 4qxj:H, 4qxj:V, 4qz0:H, 4qz0:V, 4qz1:H, 4qz1:V, 4qz2:H, 4qz2:V, 4qz3:H, 4qz3:V, 4qz4:H, 4qz4:V, 4qz5:H, 4qz5:V, 4qz6:H, 4qz6:V, 4qz7:H, 4qz7:V, 4qzw:H, 4qzw:V, 4qzx:H, 4qzx:V, 4qzz:H, 4qzz:V, 4r00:H, 4r00:V, 4r02:V, 4r17:V, 4r18:V, 8rhj:H, 8rhj:V, 8rhk:H, 8rhk:V, 8rhl:H, 8rhl:V, 4rur:V, 1ryp:I, 1ryp:W, 3sdi:H, 3sdi:V, 3sdk:H, 3un4:H, 3un4:V, 4y69:V, 4y6a:V, 4y6v:V, 4y6z:H, 4y6z:V, 4y70:H, 4y70:V, 4y74:H, 4y74:V, 4y75:V, 4y77:H, 4y77:V, 4y78:H, 4y78:V, 4y7w:H, 4y7w:V, 4y7x:V, 4y7y:H, 4y7y:V, 4y80:H, 4y80:V, 4y81:V, 4y82:H, 4y82:V, 4y84:H, 4y84:V, 4y8g:H, 4y8g:V, 4y8h:H, 4y8h:V, 4y8i:H, 4y8i:V, 4y8j:H, 4y8j:V, 4y8k:V, 4y8l:V, 4y8m:V, 4y8n:V, 4y8o:V, 4y8p:H, 4y8p:V, 4y8q:V, 4y8r:V, 4y8s:H, 4y8s:V, 4y8t:V, 4y8u:V, 4y9y:V, 4y9z:H, 4y9z:V, 4ya0:V, 4ya1:V, 4ya2:H, 4ya2:V, 4ya3:V, 4ya4:V, 4ya5:V, 4ya7:H, 4ya7:V, 4ya9:H, 4ya9:V, 4z1l:H, 4z1l:V, 2zcy:H, 2zcy:V, 6zou:H, 6zou:V, 6zp6:H, 6zp6:V, 6zp8:H, 6zp8:V
6 3mi0:R 239 70 0.1329 0.0962 0.3286 0.016 2fhh:H, 2fhh:C, 2fhh:E, 2fhh:G, 2fhh:J, 2fhh:L, 2fhh:N, 2fhh:P, 2fhh:R, 2fhh:T, 2fhh:V, 2fhh:X, 2fhh:Z, 2fhh:2, 3krd:C, 3krd:E, 3krd:R, 3krd:G, 3krd:N, 3krd:H, 3krd:J, 3krd:L, 3krd:P, 3krd:V, 3krd:T, 3krd:X, 3krd:Z, 3krd:2, 3mi0:C, 3mi0:E, 3mi0:G, 3mi0:H, 3mi0:J, 3mi0:L, 3mi0:N, 3mi0:P, 3mi0:T, 3mi0:V, 3mi0:X, 3mi0:Z, 3mi0:2, 6ocw:H, 6ocw:I, 6ocw:J, 6ocw:K, 6ocw:L, 6ocw:M, 6ocw:N, 6ocw:V, 6ocw:W, 6ocw:X, 6ocw:Y, 6ocw:Z, 6ocw:a, 6ocw:b, 6ocz:H, 6ocz:I, 6ocz:J, 6ocz:K, 6ocz:L, 6ocz:M, 6ocz:N, 6ocz:V, 6ocz:W, 6ocz:X, 6ocz:Y, 6ocz:Z, 6ocz:a, 6ocz:b, 6ode:H, 6ode:I, 6ode:J, 6ode:K, 6ode:L, 6ode:M, 6ode:N, 6ode:V, 6ode:W, 6ode:X, 6ode:Y, 6ode:Z, 6ode:a, 6ode:b, 5tho:H, 5tho:I, 5tho:J, 5tho:K, 5tho:L, 5tho:M, 5tho:N, 5tho:V, 5tho:W, 5tho:X, 5tho:Y, 5tho:Z, 5tho:a, 5tho:b, 5trg:H, 5trg:I, 5trg:J, 5trg:K, 5trg:L, 5trg:M, 5trg:N, 5trg:V, 5trg:W, 5trg:X, 5trg:Y, 5trg:Z, 5trg:a, 5trg:b, 5trr:H, 5trr:I, 5trr:J, 5trr:K, 5trr:L, 5trr:M, 5trr:N, 5trr:V, 5trr:W, 5trr:X, 5trr:Y, 5trr:Z, 5trr:a, 5trr:b, 5trs:H, 5trs:I, 5trs:J, 5trs:K, 5trs:L, 5trs:M, 5trs:N, 5trs:V, 5trs:W, 5trs:X, 5trs:Y, 5trs:Z, 5trs:a, 5trs:b, 5try:H, 5try:I, 5try:J, 5try:K, 5try:L, 5try:M, 5try:N, 5try:V, 5try:W, 5try:X, 5try:Y, 5try:Z, 5try:a, 5try:b, 5ts0:H, 5ts0:I, 5ts0:J, 5ts0:K, 5ts0:L, 5ts0:M, 5ts0:N, 5ts0:V, 5ts0:W, 5ts0:X, 5ts0:Y, 5ts0:Z, 5ts0:a, 5ts0:b, 6wnk:H, 6wnk:I, 6wnk:J, 6wnk:K, 6wnk:L, 6wnk:M, 6wnk:N, 6wnk:V, 6wnk:W, 6wnk:X, 6wnk:Y, 6wnk:Z, 6wnk:a, 6wnk:b
7 2e5m:A 403 90 0.1387 0.0596 0.2667 0.20 2e5m:B
8 8cvt:n 205 109 0.1561 0.1317 0.2477 0.25 5a0q:H, 5a0q:V, 8cvr:H, 8cvr:V, 8cvs:N, 8cvs:b, 8cvt:N, 5lez:N, 5lez:b, 5lf0:N, 5lf0:b, 5lf1:N, 5lf1:b, 5lf3:N, 5lf3:b, 5lf4:N, 5lf4:b, 5lf7:N, 5lf7:b, 4r67:H, 4r67:V, 4r67:j, 3unb:N, 3unb:b, 3unb:p, 3unb:4, 8ypk:A, 8ypk:F, 8yvp:F, 8yvp:A
9 6td5:I 219 68 0.1156 0.0913 0.2941 0.38 6td5:i
10 2pny:A 233 32 0.0809 0.0601 0.4375 0.51
11 4bqf:B 827 44 0.0867 0.0181 0.3409 0.58 4bqe:A, 4bqe:B, 4bqf:A, 4bqi:A, 4bqi:B
12 8bdc:A 963 111 0.1792 0.0322 0.2793 0.68 8bdc:B, 8bdc:C, 8bdc:D
13 2bwr:A 401 70 0.1445 0.0623 0.3571 1.1 2bwm:A, 2bwr:B, 2c25:A, 2c25:B, 2c4d:A, 4up4:A, 4up4:B
14 8cvt:O 222 127 0.1965 0.1532 0.2677 1.2 5a0q:I, 5a0q:W, 8bzl:H, 8bzl:V, 8cvr:I, 8cvr:W, 8cvs:H, 8cvs:V, 8cvt:o, 6htb:V, 6htc:H, 6htc:V, 6htd:H, 6htd:V, 6htp:H, 6htp:V, 6htr:H, 6htr:V, 6hub:H, 6hub:V, 6huc:H, 6huc:V, 6huq:H, 6huq:V, 6huu:H, 6huu:V, 6huv:H, 6huv:V, 1iru:I, 1iru:W, 5le5:H, 5le5:V, 5lex:H, 5lex:V, 5ley:H, 5ley:V, 5lez:H, 5lez:V, 5lf0:H, 5lf0:V, 5lf1:H, 5lf1:V, 5lf3:H, 5lf3:V, 5lf4:H, 5lf4:V, 5lf6:H, 5lf6:V, 5lf7:H, 5lf7:V, 4r67:I, 4r67:W, 4r67:k, 4r67:y, 3unb:H, 3unb:V, 3unb:j, 3unb:x
15 8e4n:A 901 111 0.1965 0.0377 0.3063 1.4 9b6j:A, 9b6j:B, 9b6j:C, 9b6j:D, 8e4l:A, 8e4l:B, 8e4l:C, 8e4l:D, 8e4m:A, 8e4m:B, 8e4m:C, 8e4m:D, 8e4n:B, 8e4n:C, 8e4n:D, 8e4o:A, 8e4o:D, 8e4o:B, 8e4o:C, 8e4p:A, 8e4p:B, 8e4p:C, 8e4p:D
16 4p0g:A 429 57 0.0867 0.0350 0.2632 2.0 5aa1:A, 5aa2:A, 5aa3:A, 5aa4:A, 4owd:A, 4oxv:A, 4oyv:A, 4oz9:A
17 9b6h:B 934 112 0.1965 0.0364 0.3036 2.6 9b6d:A, 9b6d:B, 9b6d:C, 9b6d:D, 9b6e:B, 9b6e:A, 9b6e:C, 9b6e:D, 9b6f:A, 9b6f:B, 9b6f:C, 9b6f:D, 9b6g:A, 9b6g:B, 9b6g:C, 9b6g:D, 9b6h:A, 9b6h:C, 9b6h:D, 9b6k:A, 9b6k:B, 9b6k:C, 9b6k:D, 7wrb:A, 7wrb:B, 7wrb:C, 7wrb:D, 7wrc:A, 7wrc:B, 7wrc:C, 7wrc:D, 7wrd:A, 7wrd:B, 7wrd:C, 7wrd:D, 7wre:A, 7wre:B, 7wre:C, 7wre:D, 7wrf:A, 7wrf:B, 7wrf:C, 7wrf:D
18 2glf:A 450 56 0.0925 0.0356 0.2857 5.0 2glf:B, 2glf:C, 2glf:D
19 4l9p:A 335 27 0.0520 0.0269 0.3333 5.5
20 5hee:A 262 82 0.1272 0.0840 0.2683 5.6 5hee:B
21 4jo0:A 522 102 0.1503 0.0498 0.2549 6.2 5kik:A, 5kil:A
22 5k36:I 224 26 0.0694 0.0536 0.4615 9.8 6fsz:II

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218