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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
TRFPKFSQDLAQDPTTRRIWYGIATAHDFESHDGMTEESLYQKLFATHFGHLAIIFLWSSGNLFHIAWQGNFEQWVSNPT
GVVPIAHAIWDPHFGKGAVEAFTPEGGAGPVNAAYSGLYYLYYTLGMRFNSDLYQGSIFLMVLATVFLIAGWLHLQPRFR
PSLAWFKNAESRLNHHLSALFGVSSLAFAGHMIHVAIPAARGQRVDWSNFLNTLPHPAGLAPFFTGNWGVYADPQAGPPI
LTFIGGLNPATGTLWLTDIAHHHLAIAVIFIIAGHMYRTNFGIGHSIKEILDAHKGPLTGEGHRGLYDTINNSLHFQLGL
ALASLGVVTSLVAQHTYALPAYFYMPQDHTTMAALYTHHQYIAGFLMVGAFAHGAIFFVRDYDPKANENNVLARMLEHKE
ALISHLSWVSLFLGFHTLGLYVHNDVMLAFGRPEDQLLIEPVFAQFVQVQSGKIIEGIPALFGGPGVTAPGEFLTGWLGS
VNANNSPIFLPIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGFAFPCDGPGRGGTCDISAWDAFYLAV
FWMLNTIGWVTFYWHWKWISIWGDNVAQFNASSTYLMGWLRDYLWANSAPLIGGYSPSGGTNALSVWAWMFLFGHLVWAT
GFMFLIAWRGYWQELIETLVWAHERTPLANLVRWKDKPVAMSIVQGRLVGLAHFTIGYILTYAAFLIASTAALYPNGPAA
FTPAI

The query sequence (length=725) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 7f4v:aB 725 725 1.0000 1.0000 1.0000 0.0 7f4v:bB, 7f4v:cB
2 6vpv:B 737 736 0.7793 0.7666 0.7677 0.0 8am5:b, 8asl:b, 8asp:b, 6hqb:B, 4kt0:B, 4l6v:B, 4l6v:b, 4l6v:2, 6nwa:B, 6nwa:b, 6nwa:G, 7o1v:B, 5oy0:B, 5oy0:b, 5oy0:2, 7umh:B, 7umh:G, 7umh:b, 6uzv:B, 6uzv:b, 6uzv:2, 6vpv:b, 6vpv:2
3 6kif:B 733 732 0.7683 0.7599 0.7609 0.0 6kif:H, 6kif:f, 6kig:B, 6kig:H, 6kig:f
4 7fix:B1 740 740 0.7655 0.7500 0.7500 0.0 7bw2:B, 4fe1:B, 7fix:B2, 7fix:B3, 1jb0:B, 6k33:aB, 6k33:bB, 6k33:cB, 7m75:B, 7m76:B, 7m78:B, 3pcq:B, 6pfy:H, 6pfy:B, 6pfy:Z, 6pgk:H, 6pgk:B, 6pgk:Z, 6tra:B, 6trc:B, 6trc:b, 6trc:2, 6trd:B, 6trd:b, 6trd:2, 5zf0:B1, 5zf0:B2, 5zf0:B3, 5zf0:B4, 5zf0:B6, 5zf0:B5
5 6kmw:aB 740 740 0.7545 0.7392 0.7392 0.0 6kmw:cB, 6kmw:bB
6 7y5e:BN 732 732 0.7517 0.7445 0.7445 0.0 7y5e:B2, 7y7a:B7, 7y7a:Bo, 7y7b:B, 7y8a:B
7 8wm6:B 732 732 0.7434 0.7363 0.7363 0.0 8wmj:B, 8wmv:B, 8wmw:B
8 7qco:B 734 736 0.7572 0.7480 0.7459 0.0 7qco:G, 7qco:g, 7qco:b
9 7blz:B 731 732 0.7393 0.7332 0.7322 0.0 6fos:B, 8wey:B, 5zgb:B, 5zgh:B
10 6igz:B 733 732 0.7393 0.7312 0.7322 0.0
11 6lu1:B 713 733 0.7462 0.7588 0.7381 0.0
12 7d0j:B 734 730 0.7338 0.7248 0.7288 0.0 7a4p:B, 7bgi:B, 7blx:B, 8cmo:B, 7dz7:B, 7dz8:B, 8h2u:B, 6ijj:B, 6ijo:B, 6jo5:B, 6jo6:B, 6qph:B, 7r3k:B, 6rhz:B, 6sl5:B, 7wyi:B, 7wzn:B, 6yxr:B, 7zq9:B, 7zqc:B, 7zqd:B, 7zqd:B2, 6zzx:B, 6zzy:B
13 7yca:B 732 731 0.7324 0.7254 0.7264 0.0
14 7wfd:AB 734 731 0.7421 0.7330 0.7360 0.0 8bcv:B, 8bcw:B, 7dkz:B, 7ew6:B, 7ewk:B, 7f9o:B, 7f9o:f, 8htu:B, 8j6z:B, 8j7a:B, 8j7b:B, 7ksq:B, 7kux:B, 6l35:B, 5l8r:B, 3lw5:B, 2o01:B, 4rku:B, 7wfe:BB, 7wg5:AB, 7wg5:BB, 8wgh:B, 2wsc:B, 2wse:B, 2wsf:B, 4xk8:B, 4xk8:b, 7xqp:B, 4y28:B, 6yac:B, 6yez:B, 5zji:B, 6zoo:B, 6zxs:B
15 6k61:B 740 740 0.7476 0.7324 0.7324 0.0 6jeo:aB, 6jeo:bB, 6jeo:cB, 6jeo:dB, 6k61:b, 6tcl:B1, 6tcl:B2, 6tcl:B, 6tcl:BB, 7y3f:B
16 6ly5:b 732 732 0.7269 0.7199 0.7199 0.0 6l4u:B
17 6kmx:aB 727 733 0.7159 0.7139 0.7080 0.0 6kmx:bB, 6kmx:cB
18 7s3d:B 742 743 0.7172 0.7008 0.6999 0.0 7s3d:H, 7s3d:b
19 7dr0:B 706 733 0.7172 0.7365 0.7094 0.0 7dr1:B, 7dr2:aB, 7dr2:bB, 7dr2:cB, 7dr2:dB
20 7lx0:H 739 740 0.7090 0.6955 0.6946 0.0 7lx0:b, 7lx0:B, 6pnj:H, 6pnj:B, 6pnj:b
21 7dwq:B 659 724 0.6634 0.7299 0.6644 0.0 7coy:aB, 7coy:bB, 7coy:cB
22 7f4v:aA 772 771 0.4979 0.4676 0.4682 0.0 7f4v:bA, 7f4v:cA
23 6k61:A 742 742 0.4800 0.4690 0.4690 0.0 6jeo:aA, 6jeo:bA, 6jeo:cA, 6jeo:dA, 6k61:a, 6tcl:A1, 6tcl:A2, 6tcl:A, 6tcl:AA, 7y3f:A
24 5oy0:A 751 747 0.4814 0.4647 0.4672 0.0 8am5:a, 8asl:a, 8asp:a, 6hqb:A, 4kt0:A, 4l6v:A, 4l6v:a, 4l6v:1, 6nwa:A, 6nwa:a, 6nwa:H, 7o1v:A, 5oy0:a, 5oy0:1, 7umh:A, 7umh:H, 7umh:a, 6uzv:A, 6uzv:a, 6uzv:1, 6vpv:A, 6vpv:a, 6vpv:1
25 6tra:A 746 758 0.4883 0.4745 0.4670 0.0 4fe1:A, 7fix:A1, 7fix:A2, 7fix:A3, 1jb0:A, 6k33:aA, 6k33:bA, 6k33:cA, 6lu1:A, 7m75:A, 7m76:A, 7m78:A, 3pcq:A, 6pfy:A, 6pfy:G, 6pfy:Y, 6pgk:A, 6pgk:G, 6pgk:Y, 6trc:A, 6trc:a, 6trc:1, 6trd:A, 6trd:a, 6trd:1, 5zf0:A1, 5zf0:A2, 5zf0:A3, 5zf0:A4, 5zf0:A6, 5zf0:A5
26 7qco:A 728 747 0.4772 0.4753 0.4632 0.0 7qco:E, 7qco:e, 7qco:a
27 7dwq:A 726 746 0.4566 0.4559 0.4437 0.0
28 7dr0:A 739 742 0.4676 0.4587 0.4569 0.0 7dr1:A, 7dr2:aA, 7dr2:bA, 7dr2:cA, 7dr2:dA
29 5l8r:A 743 748 0.4745 0.4630 0.4599 0.0 8bcv:A, 8bcw:A, 7dkz:A, 7ew6:A, 7ewk:A, 7f9o:A, 7f9o:e, 8htu:A, 8j6z:A, 8j7a:A, 8j7b:A, 7ksq:A, 7kux:A, 6l35:A, 3lw5:A, 2o01:A, 4rku:A, 7wfd:AA, 7wfe:BA, 7wg5:AA, 7wg5:BA, 8wgh:A, 2wsc:A, 2wse:A, 2wsf:A, 4xk8:A, 4xk8:a, 7xqp:A, 4y28:A, 6yac:A, 6yez:A, 5zji:A, 6zoo:A, 6zxs:A
30 7blz:A 743 747 0.4759 0.4643 0.4618 0.0 6fos:A, 8wey:A, 5zgb:A, 5zgh:A
31 7yca:A 742 746 0.4676 0.4569 0.4544 0.0 7a4p:A, 7bgi:A, 7blx:A, 8cmo:A, 7d0j:A, 7dz7:A, 7dz8:A, 8h2u:A, 6ijj:A, 6ijo:A, 6jo5:A, 6jo6:A, 7r3k:A, 7wyi:A, 7wzn:A, 7zq9:A, 7zqc:A, 7zqd:A, 7zqd:A2, 6zzx:A, 6zzy:A
32 7y5e:AN 745 747 0.4621 0.4497 0.4485 0.0 7y5e:A2, 7y7a:A7, 7y7a:Ao
33 6kif:A 751 760 0.4731 0.4567 0.4513 0.0 6kif:G, 6kif:e, 6kig:A, 6kig:G, 6kig:e
34 6kmw:aA 721 745 0.4703 0.4730 0.4577 0.0 6kmw:bA, 6kmw:cA
35 8wm6:A 742 747 0.4593 0.4488 0.4458 0.0 8wmj:A, 8wmv:A, 8wmw:A, 7y7b:A, 7y8a:A
36 6igz:A 740 740 0.4607 0.4514 0.4514 0.0 6qph:A, 6rhz:A, 6sl5:A, 6yxr:A
37 6ly5:a 742 747 0.4579 0.4474 0.4444 0.0 6l4u:A
38 7coy:aA 685 718 0.4414 0.4672 0.4457 0.0 7coy:bA, 7coy:cA
39 7s3d:A 749 750 0.4566 0.4419 0.4413 0.0 7s3d:G, 7s3d:a
40 7lx0:G 751 756 0.4538 0.4381 0.4352 0.0 7lx0:a, 7lx0:A, 6pnj:A, 6pnj:G, 6pnj:a
41 6kmx:aA 717 743 0.4483 0.4533 0.4374 0.0 6kmx:bA, 6kmx:cA
42 8jjr:b 659 723 0.4469 0.4917 0.4481 2.31e-180
43 8jze:b 663 724 0.4317 0.4721 0.4323 5.92e-179 8jzf:b
44 8jw0:b 617 703 0.4055 0.4765 0.4182 2.06e-171
45 8jjr:a 665 735 0.3338 0.3639 0.3293 4.21e-112
46 8jze:a 670 726 0.3076 0.3328 0.3072 1.98e-99 8jzf:a
47 8jw0:a 645 725 0.3241 0.3643 0.3241 9.60e-97
48 7zq9:B2 180 214 0.1724 0.6944 0.5841 1.12e-72
49 7zq9:B2 180 27 0.0221 0.0889 0.5926 0.042
50 5v8k:A 600 219 0.0883 0.1067 0.2922 2.68e-11
51 6m32:A 628 87 0.0400 0.0462 0.3333 2.27e-05 6m32:a
52 8gwa:A 667 87 0.0400 0.0435 0.3333 2.49e-05 8gwa:a, 7uea:A, 7uea:a, 7ueb:A, 7ueb:a, 7z6q:A, 7z6q:a
53 7vzg:a 858 123 0.0414 0.0350 0.2439 0.020 7vzg:A, 7vzr:A, 7vzr:a
54 6yq4:B 480 75 0.0359 0.0542 0.3467 0.18 6yq4:A, 6yq4:C
55 8bpx:L 665 203 0.0662 0.0722 0.2365 3.1 8bef:L
56 4pyu:A 76 27 0.0179 0.1711 0.4815 6.9 4pyu:B, 4pyu:G, 4pyu:K, 4pyu:O, 4pyu:S, 8q7n:s
57 3st1:A 212 84 0.0317 0.1085 0.2738 8.6
58 4v5i:AS 298 28 0.0166 0.0403 0.4286 9.1 4v5i:AT, 4v5i:AU, 4v5i:AV, 4v5i:AW, 4v5i:AX, 4v5i:BS, 4v5i:BT, 4v5i:BU, 4v5i:BV, 4v5i:BW, 4v5i:BX

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218