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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
TNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEW
LGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEE
GKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLRTLEFQDNRRLYDWVLDNI
TIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASL
ESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGK
EVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVI
KQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDT

The query sequence (length=529) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4jyz:A 542 540 0.9981 0.9742 0.9778 0.0 1euq:A, 1euy:A, 1exd:A, 1gtr:A, 1gts:A, 4jxx:A, 4jxz:A, 1o0b:A, 1o0c:A, 1qrs:A, 1qrt:A, 1qru:A, 1qtq:A, 2rd2:A, 2re8:A, 1zjw:A
2 5zdk:A 543 543 0.5236 0.5101 0.5101 3.06e-180 5zdl:A
3 4h3s:A 585 548 0.4423 0.4000 0.4270 8.01e-134
4 8uk6:A 573 543 0.4291 0.3962 0.4180 6.14e-125
5 7wao:A 502 503 0.3497 0.3685 0.3678 1.29e-84 7waj:A, 7wak:A, 7wal:A
6 3aii:A 455 501 0.2892 0.3363 0.3054 1.15e-54
7 2cfo:A 484 347 0.1758 0.1921 0.2680 1.23e-16
8 8i9i:A 468 122 0.0662 0.0748 0.2869 5.84e-13 8i9i:B
9 4g6z:A 380 297 0.1342 0.1868 0.2391 3.52e-12
10 8vc5:A 488 232 0.1210 0.1311 0.2759 1.94e-09 8vc5:B
11 4gri:B 485 220 0.1040 0.1134 0.2500 1.34e-08 4gri:A
12 3al0:C 564 76 0.0454 0.0426 0.3158 1.23e-07 3afh:A, 3akz:B, 3akz:D, 3akz:C, 3akz:A
13 4a91:A 290 105 0.0586 0.1069 0.2952 1.89e-07 1nzj:A
14 6brl:A 502 333 0.1456 0.1534 0.2312 4.38e-07
15 2cuz:A 468 402 0.1815 0.2051 0.2388 4.51e-07 2cv0:A, 2cv0:B, 2cv1:A, 2cv1:B, 2cv2:A, 2cv2:B, 2dxi:A, 2dxi:B, 1g59:A, 1g59:C, 1j09:A, 1n75:A, 1n77:A, 1n77:B, 1n78:A, 1n78:B
16 7zel:A 827 76 0.0378 0.0242 0.2632 0.46 7zel:B, 7zep:B, 7zes:A, 7zes:B
17 5ah5:A 789 134 0.0681 0.0456 0.2687 0.55 5ah5:B
18 6fyx:d 55 40 0.0321 0.3091 0.4250 1.7 6fyy:d, 6gsm:d, 6gsn:d, 8i7j:d, 5it7:d, 5it9:d, 3j80:d, 3j81:d, 3jam:d, 3jap:d, 8rw1:d, 8s8d:d, 8s8e:d, 8s8f:d, 8s8g:d, 8s8h:d, 8s8i:d, 8s8j:d, 6uz7:d
19 2fna:A 352 171 0.0756 0.1136 0.2339 2.4 2fna:B
20 6srn:A 187 53 0.0284 0.0802 0.2830 3.0
21 4ari:A 821 109 0.0529 0.0341 0.2569 3.3 4arc:A, 4as1:A, 8pot:A, 3zjt:A, 3zju:A, 3zjv:A
22 3zgz:D 867 109 0.0529 0.0323 0.2569 3.5 2ajh:A, 2ajh:B, 2aji:A, 2aji:B, 4aq7:A, 4aq7:D, 4cqn:A, 4cqn:D, 5omw:A, 5omw:D, 5on2:A, 5on2:D, 5on3:A, 5on3:D, 5onh:A, 5onh:D, 3zgz:A
23 8gui:L 73 39 0.0246 0.1781 0.3333 6.2 8guj:L, 8iej:A
24 3b2s:A 448 23 0.0227 0.0268 0.5217 6.5 3b30:A, 2rkv:A
25 7qep:L3 363 128 0.0586 0.0854 0.2422 7.0
26 1hlm:A 158 34 0.0246 0.0823 0.3824 9.4
27 7agj:A 731 38 0.0246 0.0178 0.3421 9.8 7agj:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218