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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
SMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLVKDGLIIKKPVTVHSRARCRKNTLARRKGRHMGVGKR
KGTANARMPEKLCWMRRMRILRRLLRRYREAKKIDRHMYHSLYLRAKGNVFKNKRILMEHIHKLKADKARKKLLADQAEA
RRTKTR

The query sequence (length=166) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4v6x:CR 189 166 0.9398 0.8254 0.9398 5.40e-102 7a01:32, 8a3d:L, 5aj0:AR, 8b5l:R, 8b6c:R, 9bdl:AL19, 9bdn:AL19, 9bdp:AL19, 8bf9:R, 7bhp:LR, 8bhf:E1, 8bpo:Q2, 8btk:BR, 7cpu:LR, 7cpv:LR, 4d5y:R, 4d67:R, 6d90:R, 6d9j:R, 9f1b:BR, 9f1c:BR, 9f1d:BR, 7f5s:LR, 8fl2:LD, 8fl3:LD, 8fl4:LD, 8fl6:LD, 8fl7:LD, 8fl9:LD, 8fla:LD, 8flb:LD, 8flc:LD, 8fld:LD, 8fle:LD, 8flf:LD, 9fpz:LR, 9fq0:LR, 6frk:R, 6ftg:R, 6fti:R, 6ftj:R, 8g5y:LR, 8g5z:LR, 8g60:LR, 8g61:LR, 8g6j:LR, 8glp:LR, 6gz3:AR, 6gz4:AR, 6gz5:AR, 6hcf:R3, 6hcj:R3, 6hcm:R3, 6hcq:R3, 8idt:a, 8idy:a, 8ie3:a, 8ifd:2L, 8ife:2L, 8ine:a, 8inf:a, 8ink:a, 6ip5:2L, 6ip6:2L, 6ip8:2L, 8ipd:a, 8ipx:a, 8ipy:a, 8ir1:a, 8ir3:a, 3j7o:R, 3j7p:R, 3j7q:R, 3j7r:R, 3j92:R, 3jag:R, 3jah:R, 3jai:R, 3jaj:R, 3jan:R, 8jdj:W, 8jdk:W, 8jdl:W, 8jdm:W, 8k2c:LR, 5lks:LR, 6lqm:a, 6lsr:a, 6lss:a, 7ls1:L2, 7ls2:L2, 6lu8:a, 5lzs:R, 5lzt:R, 5lzu:R, 5lzv:R, 5lzw:R, 5lzx:R, 5lzy:R, 5lzz:R, 7mdz:R, 6mtb:R, 6mtc:R, 6mtd:R, 6mte:R, 7nfx:R, 7nwg:R3, 7nwh:R, 7nwi:R, 7o7y:BR, 7o7z:BR, 7o80:BR, 7o81:BR, 7obr:R, 8ohd:LR, 8oj0:LR, 8oj5:LR, 8oj8:LR, 6ole:S, 6olf:S, 6olg:AR, 6oli:S, 6olz:AR, 6om0:S, 6om7:S, 8ony:LR, 7oya:R1, 7oyb:R1, 7oyc:R1, 7oyd:R, 8p2k:BR, 6p5i:AR, 6p5j:AR, 6p5k:AR, 6p5n:AR, 8q7z:BR, 8q87:BR, 8qfd:R, 7qgg:S, 8qoi:LR, 7qvp:LR, 7qvp:MR, 7qwq:R, 7qwr:R, 7qws:R, 6qzp:LR, 6r5q:R, 6r6g:R, 6r6p:R, 6r7q:R, 8rjb:R, 8rjc:R, 8rjd:R, 8scb:R, 6sgc:R2, 6swa:o, 6sxo:LR, 5t2c:L, 6t59:R3, 7tm3:R, 7toq:AL19, 7tor:AL19, 7tut:R, 7ucj:R, 7uck:R, 4ug0:LR, 4ujc:BR, 4ujd:AR, 4uje:CR, 6xa1:LR, 7xnx:LR, 7xny:LR, 8xsx:LR, 8xsy:LR, 8xsz:LR, 6y0g:LR, 8y0w:LR, 8y0x:LR, 6y2l:LR, 6y57:LR, 6y6x:LR, 8yoo:LR, 8yop:LR, 6z6l:LR, 6z6m:LR, 6z6n:LR, 7zjw:LU, 7zjx:LU, 6zm7:LR, 6zme:LR, 6zmi:LR, 6zmo:LR, 6zvk:32
2 4v6w:CR 203 165 0.7771 0.6355 0.7818 2.76e-92 6xu6:CR, 6xu7:CR, 6xu8:CR
3 6w6l:S 156 166 0.8253 0.8782 0.8253 4.33e-83 8fky:LD, 8fkz:LD, 7ow7:L
4 9bh5:CR 194 166 0.7048 0.6031 0.7048 8.96e-75 9cai:CR
5 8azw:H 182 164 0.6988 0.6374 0.7073 2.15e-74 8b2l:H3, 7qiw:T, 7qix:X, 7qiz:T
6 4v3p:LT 189 164 0.6928 0.6085 0.7012 6.39e-73 8ip8:LA, 8ipa:LA, 8ipb:LA, 8jiv:CR, 4v7e:CR
7 7r81:T1 191 164 0.6566 0.5707 0.6646 1.64e-70 7olc:LR, 7old:LR, 8onz:LR, 8oo0:LR, 8pv1:LR, 8pv2:LR, 8pv3:LR, 8pv4:LR, 8pv5:LR, 8pv6:LR, 8pv7:LR, 8pv8:LR, 8pvk:LR, 8pvl:LR, 7z3n:LR, 7z3o:LR
8 4v5z:Bp 159 159 0.7590 0.7925 0.7925 3.83e-70
9 6zj3:Lf 170 163 0.6205 0.6059 0.6319 1.47e-69
10 4v8m:BT 199 162 0.6205 0.5176 0.6358 5.69e-63 8ova:BT, 8ove:BT, 5t5h:T
11 4v6i:BT 189 163 0.6084 0.5344 0.6196 1.29e-62 8aaf:E, 8agt:E, 8agu:E, 8agv:E, 8agw:E, 8agx:E, 8agz:E, 5apn:R, 5apo:R, 7azy:H, 7b7d:Ln, 8bip:LR, 8bjq:LR, 8bn3:M9, 8bqd:BF, 8bqx:BF, 7bt6:R, 7btb:R, 8ccs:D, 8cdl:D, 8cdr:D, 8ceh:D, 8cf5:D, 8cg8:D, 8cgn:D, 8civ:D, 8cku:D, 8cmj:D, 5dat:M9, 5dat:m9, 5dc3:M9, 5dc3:m9, 5dge:M9, 5dge:m9, 5dgf:M9, 5dgf:m9, 5dgv:M9, 5dgv:m9, 8eub:AR, 8evp:AR, 8evq:AR, 8evr:AR, 8evs:AR, 8evt:AR, 8ewb:AR, 8ewc:AR, 5fci:M9, 5fci:m9, 5fcj:M9, 5fcj:m9, 6ft6:R, 5gak:T, 6gq1:R, 6gqb:R, 6gqv:R, 5h4p:R, 6hd7:T, 8hfr:RP, 6hhq:z, 6hhq:CT, 5i4l:M9, 5i4l:m9, 6i7o:BF, 6i7o:YF, 3j6x:59, 3j6y:59, 3j77:69, 3j78:69, 3jct:R, 5jcs:R, 5juo:W, 5jup:W, 5jus:W, 5jut:W, 5juu:W, 8k2d:LR, 8k82:LR, 5lyb:M9, 5lyb:m9, 5m1j:R5, 6m62:R, 5mc6:BF, 5mei:z, 5mei:CT, 7mpi:AR, 7mpj:AR, 6n8j:R, 6n8k:R, 6n8l:R, 6n8m:e, 6n8n:e, 6n8o:e, 7n8b:AR, 5ndg:M9, 5ndg:m9, 5ndv:M9, 5ndv:m9, 5ndw:M9, 5ndw:m9, 7nrc:LT, 7nrd:LT, 5obm:M9, 5obm:m9, 7of1:R, 7oh3:R, 7ohq:R, 6oig:R, 5on6:z, 5on6:CT, 7osa:eL19, 7osm:eL19, 8p8m:QQ, 8p8n:QQ, 8p8u:QQ, 8pfr:QQ, 6q8y:BF, 6qik:R, 6qt0:R, 6qtz:R, 6r84:T, 6r86:T, 6r87:T, 6ri5:R, 7rr5:LR, 6rzz:R, 6s05:R, 6s47:AT, 6snt:x, 6sv4:BF, 6sv4:YF, 6sv4:ZF, 6t4q:LR, 5t62:e, 5t6r:e, 6t7i:LR, 6t7t:LR, 6t83:Ry, 6t83:C, 5tbw:z, 5tbw:CT, 6tb3:BF, 5tga:M9, 5tga:m9, 5tgm:M9, 5tgm:m9, 6tnu:BF, 7too:AL19, 7top:AL19, 7u0h:R, 4u3m:M9, 4u3m:m9, 4u3n:M9, 4u3n:m9, 4u3u:M9, 4u3u:m9, 4u4n:M9, 4u4n:m9, 4u4o:M9, 4u4o:m9, 4u4q:M9, 4u4q:m9, 4u4r:M9, 4u4r:m9, 4u4u:M9, 4u4u:m9, 4u4y:M9, 4u4y:m9, 4u4z:M9, 4u4z:m9, 4u50:M9, 4u50:m9, 4u51:M9, 4u51:m9, 4u52:M9, 4u52:m9, 4u53:M9, 4u53:m9, 4u55:M9, 4u55:m9, 4u56:M9, 4u56:m9, 4u6f:M9, 4u6f:m9, 7ug6:R, 7uoo:R, 7uqb:R, 7uqz:R, 7v08:R, 4v4b:BP, 4v7f:R, 4v7r:BS, 4v7r:DS, 4v88:BR, 4v88:DR, 4v8t:R, 4v8y:BR, 4v8z:BR, 4v91:R, 6woo:R, 2ww9:J, 2wwa:J, 2wwb:J, 6xiq:R, 6xir:R, 8y0u:LR, 6ylg:R, 6ylh:R, 6ylx:R, 6yly:R, 7z34:R, 6z6j:LR, 6z6k:LR, 7zpq:BQ, 7zrs:BQ, 7zs5:BS, 7zuw:BQ, 7zux:EQ, 7zw0:LU
12 4v8p:BO 184 162 0.6205 0.5598 0.6358 1.94e-62 4v8p:EO, 4v8p:GO
13 5it7:RR 188 162 0.6024 0.5319 0.6173 2.26e-62 6uz7:AR
14 5xxb:Q 176 163 0.6084 0.5739 0.6196 2.63e-62
15 3j79:T 181 164 0.6205 0.5691 0.6280 3.59e-62 3jbn:AT, 3jbo:AT, 3jbp:AT, 8tpu:AT, 5umd:T
16 8rxh:LQ 201 159 0.6205 0.5124 0.6478 1.14e-61 8a3w:Q, 8a98:Q, 6az3:Q, 3jcs:Q, 8ovj:Q, 8rxx:LQ, 5t2a:R
17 8eui:R 149 145 0.5904 0.6577 0.6759 9.07e-61 8etg:R, 8etj:R, 8eug:R
18 5xy3:R 162 162 0.5602 0.5741 0.5741 9.29e-61
19 8c3a:z 179 155 0.5904 0.5475 0.6323 1.45e-60 8c3a:BM, 8cq7:z, 8cq7:BM, 8cqw:z, 8cqw:BM, 8cre:z, 8cre:BM, 8oeq:z, 8oeq:BM, 7pzy:z, 7q08:z, 7q0f:z, 7q0p:z, 7q0r:z, 8q5i:z
20 4v8p:CO 175 144 0.5663 0.5371 0.6528 1.60e-56
21 4v7h:BP 176 139 0.5361 0.5057 0.6403 1.17e-55
22 8i9z:LR 148 164 0.5361 0.6014 0.5427 2.72e-51 8i9x:LR, 8i9y:LR, 8ia0:LR
23 6zu5:LR0 161 154 0.4458 0.4596 0.4805 1.13e-50
24 8br8:LS 192 139 0.4578 0.3958 0.5468 3.40e-48 8brm:LS, 8bsi:LS, 8bsj:LS, 8btd:LS, 8btr:LS, 8fru:R, 7pwg:R, 7pwo:R2
25 7nac:R 134 159 0.5120 0.6343 0.5346 6.05e-46 6elz:R, 6em5:R, 7nad:R, 7naf:R, 7ohr:R, 7r72:R, 7r7a:R, 8v87:R
26 7qep:M9 170 154 0.4518 0.4412 0.4870 8.60e-45
27 8etc:R 124 139 0.4880 0.6532 0.5827 1.15e-43 8esq:R, 8esr:R
28 6skf:BS 146 136 0.3855 0.4384 0.4706 2.99e-40 6skg:BS, 6th6:BS
29 6rm3:LR0 165 156 0.4157 0.4182 0.4423 1.46e-39
30 4v4n:AQ 150 144 0.3735 0.4133 0.4306 4.42e-38 4v6u:BQ
31 8p5d:LR0 164 154 0.3855 0.3902 0.4156 2.75e-35 8p60:LR0, 8p60:KR0, 7qca:LR0
32 4v9f:P 144 140 0.3193 0.3681 0.3786 3.04e-25 3cc2:P, 3cc4:P, 3cc7:P, 3cce:P, 3ccj:P, 3ccl:P, 3ccm:P, 3ccq:P, 3ccr:P, 3ccs:P, 3ccu:P, 3ccv:P, 3cd6:P, 3cma:P, 3cme:P, 3cpw:O, 3cxc:O, 1ffk:M, 3g4s:P, 3g6e:P, 3g71:P, 3i55:P, 3i56:P, 1jj2:O, 1k73:Q, 1k8a:Q, 1k9m:Q, 1kc8:Q, 1kd1:Q, 1kqs:O, 1m1k:Q, 1m90:Q, 1n8r:Q, 1nji:Q, 2otj:P, 2otl:P, 3ow2:O, 1q7y:Q, 1q81:Q, 1q82:Q, 1q86:Q, 2qa4:P, 2qex:P, 1qvf:O, 1qvg:O, 1s72:P, 1vq4:P, 1vq5:P, 1vq6:P, 1vq7:P, 1vq8:P, 1vq9:P, 1vqk:P, 1vql:P, 1vqm:P, 1vqn:P, 1vqo:P, 1vqp:P, 1w2b:O, 1yhq:P, 1yi2:P, 1yij:P, 1yit:P, 1yj9:P, 1yjn:P, 1yjw:P
33 7ohv:R 89 125 0.3554 0.6629 0.4720 8.05e-24
34 8hku:L19E 144 132 0.2952 0.3403 0.3712 9.49e-21 8hkv:L19E, 8hky:L19E, 8hkz:L19E, 8hl1:L19E, 8hl2:L19E, 8hl3:L19E, 8hl4:L19E, 8hl5:L19E
35 8rsl:A 271 43 0.0964 0.0590 0.3721 5.5 5kiv:A, 8rsl:B
36 3thu:A 405 44 0.0783 0.0321 0.2955 5.8 3thu:B, 3thu:C
37 7ajt:JG 230 38 0.0843 0.0609 0.3684 6.4 7aju:JG, 7d4i:RG, 7d4i:RH, 7d5s:RG, 7d5s:RH, 7d63:RG, 7d63:RH, 5jpq:f, 6ke6:RG, 6ke6:RH, 6lqp:RG, 6lqp:RH, 6lqq:RG, 6lqq:RH, 6lqr:RG, 6lqr:RH, 6lqs:RG, 6lqs:RH, 6lqt:RH, 6lqu:RG, 6lqu:RH, 6lqv:RG, 6lqv:RH, 3oii:A, 3oii:B, 3oij:A, 3oij:B, 3oin:A, 3oin:B, 7suk:SJ, 7suk:SK, 2v3k:A, 5wlc:SJ, 5wlc:SK, 5wyj:E1, 5wyj:E2, 5wyk:E1, 5wyk:E2, 6zqa:JG, 6zqb:JG, 6zqc:JG, 6zqd:JG, 6zqe:JG, 6zqg:JG

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218