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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
SKTILVKMMSQAGTGFSFNTKRSRLREKLTLLHYDPVVKKKVLFVEQK

The query sequence (length=48) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6gaw:B6 52 48 1.0000 0.9231 1.0000 1.27e-29 5aj4:B6, 4ce4:6, 6gb2:B6, 7nqh:B6, 7nql:B6, 7nsh:B6, 7nsi:B6, 7nsj:B6, 8oin:BI, 8oiq:BI, 4v19:6, 6ydp:B6, 6ydw:B6
2 8any:1 56 48 0.8125 0.6964 0.8125 1.35e-24 7a5f:13, 7a5g:13, 7a5h:1, 7a5i:13, 7a5j:1, 7a5k:13, 6i9r:1, 3j7y:1, 3j9m:1, 8k2a:Lg, 8k2b:Lg, 7l08:1, 7l20:1, 6nu2:1, 6nu3:1, 7o9k:1, 7o9m:1, 7odr:1, 7ods:1, 7odt:1, 7of0:1, 7of2:1, 7of3:1, 7of4:1, 7of5:1, 7of6:1, 7of7:1, 7og4:1, 7oi7:1, 7oi8:1, 7oi9:1, 7oia:1, 7oib:1, 7oic:1, 7oid:1, 7oie:1, 8oir:BI, 8oit:BI, 5ool:1, 5oom:1, 7pd3:1, 8pk0:1, 7po4:1, 7qh6:1, 7qh7:1, 7qi4:1, 7qi5:1, 7qi6:1, 8qsj:1, 8qu1:1, 8qu5:1, 6vlz:1, 6vmi:1, 8xt0:Lg, 8xt1:Lg, 8xt2:Lg, 8xt3:Lg, 6zm5:1, 6zm6:1, 6zs9:1, 6zsa:1, 6zsb:1, 6zsc:1, 6zsd:1, 6zse:1, 6zsg:1
3 6ywe:X 48 48 0.4375 0.4375 0.4375 5.72e-10 6yws:X, 6ywv:X, 6ywx:X, 6ywy:X
4 4io9:1 53 47 0.5208 0.4717 0.5319 1.71e-09 7a0r:1, 7a0s:1, 7a18:1, 4ioc:1, 5jvg:1, 5jvh:1, 3pio:1, 3pip:1, 1sm1:1, 4u67:1, 4v49:B1, 4v4a:B1, 4v4g:B3, 4v4g:D3, 4v4g:F3, 4v4g:H3, 4v4g:J3, 4v4p:A6, 4v4r:B6, 4v4s:B6, 4v4t:B6, 4wfn:1, 2zjp:1, 2zjr:1
5 6xyw:AC 51 47 0.4375 0.4118 0.4468 7.22e-07
6 6z1p:AE 57 49 0.4375 0.3684 0.4286 7.75e-07
7 6dzi:c 53 46 0.3542 0.3208 0.3696 1.27e-06 6dzp:c, 8fr8:c, 5xym:1
8 7pkt:z 53 47 0.4583 0.4151 0.4681 9.26e-06
9 7unr:5 51 46 0.3542 0.3333 0.3696 1.75e-05 6spb:3, 6spd:3, 6spf:3, 6spg:3, 7unu:5, 7unv:5, 7unw:5
10 5aka:1 54 45 0.4375 0.3889 0.4667 3.22e-05 8a3l:0, 7abz:c, 7ac7:c, 7acj:c, 7acr:c, 5ady:1, 5afi:1, 8akn:0, 8am9:0, 8ana:0, 8ap4:0, 9ax7:0, 9ax8:6, 8aye:0, 8b0x:0, 7b5k:1, 8b7y:j, 3bbx:1, 8bf7:b, 8bge:b, 8bgh:b, 8bh4:b, 8bhj:b, 8bhl:b, 8bhn:b, 8bhp:b, 8bil:b, 8bim:b, 7bl2:1, 7bl3:1, 7bl4:1, 7bl5:1, 7bl6:1, 6bu8:31, 7bv8:c, 6by1:C2, 6by1:D2, 6c4i:3, 8c8x:1, 8cam:0, 8ceu:0, 8cgd:0, 8cgk:0, 8cgv:0, 9cg5:0, 9cg6:0, 9cg7:0, 7cpj:1, 4csu:4, 7d6z:b, 7d80:z, 6dnc:GA, 8eiu:0, 8ekc:5, 8emm:0, 6enf:1, 6enj:1, 6enu:1, 9fbv:0, 8fiz:BI, 8fto:0, 8fzd:5, 8fze:5, 8fzf:5, 8fzg:5, 8fzh:5, 8fzi:5, 8fzj:5, 8g2u:1, 8g31:1, 8g34:1, 8g38:1, 8g6w:0, 8g6x:0, 8g6y:0, 8g7p:5, 8g7q:5, 8g7r:5, 8g7s:5, 5gad:c, 5gae:c, 5gaf:c, 5gag:c, 5gah:c, 6gbz:1, 6gc0:1, 6gc8:1, 6gwt:1, 6gxm:1, 6gxn:1, 6gxo:1, 6gxp:1, 6h4n:1, 5h5u:c, 6h58:1, 6h58:11, 6hrm:c, 8hsp:0, 8htz:0, 8hu1:0, 6i0y:1, 6i7v:D2, 6i7v:C2, 8ifb:0, 8ifc:0, 5iqr:c, 5it8:C2, 5it8:D2, 8j1z:0, 2j28:1, 3j5l:1, 5j5b:C2, 5j5b:D2, 3j7z:1, 5j7l:C2, 5j7l:D2, 5j88:C2, 5j88:D2, 5j8a:C2, 5j8a:D2, 3j9y:1, 3j9z:L2, 5j91:C2, 5j91:D2, 3ja1:L4, 3jbu:4, 3jbv:4, 3jcd:1, 3jce:1, 3jcj:a, 3jcn:1, 5jc9:C2, 5jc9:D2, 7jss:C, 7jsw:C, 7jsz:C, 5jte:B1, 7jt1:C, 7jt2:C, 7jt3:C, 5ju8:B1, 7k00:0, 7k50:C, 7k51:C, 7k52:C, 7k53:C, 7k54:C, 7k55:C, 5kcr:16, 5kcs:16, 5kps:3, 5kpv:2, 5kpw:2, 5kpx:2, 5l3p:6, 6lkq:j, 7lv0:C, 7lvk:j, 5lza:1, 5lzb:1, 5lzc:1, 5lzd:1, 5lze:1, 5lzf:1, 7m5d:c, 5mdv:c, 5mdw:c, 5mdy:c, 5mdz:c, 5mgp:1, 7n1p:Lg, 7n2c:Lg, 7n2u:Lg, 7n2v:Lg, 7n30:Lg, 7n31:Lg, 7nbu:0, 5nco:c, 5np6:z, 7nso:1, 7nsp:1, 7nsq:1, 5nwy:o, 7nwt:c, 7nww:b, 7o19:B1, 7o1a:B1, 7o1c:B1, 5o2r:1, 6o9j:2, 6o9k:6, 6ofx:C, 6og7:C, 6ogf:C, 6ogg:C, 6ogi:C, 7oif:b, 7oig:b, 7oii:b, 7oiz:0, 7oj0:0, 6om6:c, 6ore:c, 6orl:c, 6osk:c, 6osq:c, 6ost:c, 6ot3:c, 7ot5:b, 7otc:1, 6ouo:c, 8p16:c, 8p17:c, 8p18:c, 7p3k:0, 8peg:g, 8phj:0, 6pj6:j, 7pjs:1, 7pjt:1, 7pju:1, 7pjv:1, 7pjw:1, 7pjx:1, 7pjy:1, 7pjz:1, 8pkl:g, 8pva:0, 7q4k:B1, 8q4f:0, 6q97:c, 6q98:c, 6q9a:c, 8qbt:b, 6qdw:4, 7qg8:o, 7qgh:o, 7qgn:o, 7qgr:o, 8qk7:c, 8qoa:0, 7qq3:j, 6qul:c, 8r3v:g2, 8r6c:0, 8r8m:0, 8rcl:g2, 8rcm:g2, 8rcs:g2, 8rct:g2, 8rpy:1, 8rpz:1, 8rq0:1, 8rq2:1, 6s0k:c, 7s1g:j, 7s1h:j, 7s1i:j, 7s1j:j, 7s1k:j, 7sa4:c, 7ss9:C, 7ssd:C, 7ssl:C, 7ssn:C, 7sso:C, 7ssw:C, 7st2:C, 7st6:C, 7st7:C, 8syl:5, 6szs:1, 8t5d:1, 8t5h:1, 6tbv:L331, 6tc3:L331, 7tos:L33, 4u1u:B1, 4u1u:D1, 4u1v:B1, 4u1v:D1, 4u20:B1, 4u20:D1, 4u24:B1, 4u24:D1, 4u25:B1, 4u25:D1, 4u26:B1, 4u26:D1, 4u27:B1, 4u27:D1, 5u4i:2, 6u48:C2, 5u9f:31, 5u9g:31, 7ug7:Lg, 7uph:j, 8upo:k, 8upr:k, 8uql:k, 8uqm:k, 8uqp:k, 8ur0:k, 8urh:k, 8uri:k, 8urx:k, 8ury:k, 4uy8:1, 5uyk:31, 5uyl:31, 5uym:31, 5uyn:31, 5uyp:31, 5uyq:31, 4v4h:B1, 4v4h:D1, 4v4q:B1, 4v4q:D1, 4v4v:B1, 4v4w:B1, 4v50:B1, 4v50:D1, 4v52:B1, 4v52:D1, 4v53:B1, 4v53:D1, 4v54:B1, 4v54:D1, 4v55:B1, 4v55:D1, 4v56:B1, 4v56:D1, 4v57:B1, 4v57:D1, 4v5b:A1, 4v5b:C1, 4v5h:B4, 4v5y:B1, 4v5y:D1, 4v64:B1, 4v64:D1, 4v65:BU, 4v66:BU, 4v69:B1, 4v6c:B1, 4v6c:D1, 4v6d:B1, 4v6d:D1, 4v6e:B1, 4v6e:D1, 4v6k:Ad, 4v6l:Bd, 4v6m:B1, 4v6n:A4, 4v6o:B4, 4v6p:B4, 4v6q:B4, 4v6r:B4, 4v6s:A4, 4v6t:B1, 4v6v:B6, 4v6y:B1, 4v6z:B1, 4v70:B1, 4v71:B1, 4v72:B1, 4v73:B1, 4v74:B1, 4v75:B1, 4v76:B1, 4v77:B1, 4v78:B1, 4v79:B1, 4v7a:B1, 4v7b:B1, 4v7c:B4, 4v7d:A5, 4v7i:A1, 4v7s:B1, 4v7s:D1, 4v7t:B1, 4v7t:D1, 4v7u:B1, 4v7u:D1, 4v7v:B1, 4v7v:D1, 4v85:B5, 4v89:B5, 4v9c:B1, 4v9c:D1, 4v9d:C1, 4v9d:D1, 4v9o:A1, 4v9o:C1, 4v9o:E1, 4v9o:G1, 4v9p:A1, 4v9p:C1, 4v9p:E1, 4v9p:G1, 8vs9:L33, 8vsa:L33, 6vu3:k, 6vwl:Z, 6vwm:Z, 6vwn:Z, 6vyq:k, 6vyr:k, 6vys:k, 6vyt:k, 6vyu:k, 6vyw:k, 6vyx:k, 6vyy:k, 6vyz:k, 6vz2:k, 6vz3:k, 6vz5:k, 6vz7:k, 6vzj:k, 8w51:2, 5wdt:1, 6wd0:C, 6wd1:C, 6wd2:C, 6wd3:C, 6wd4:C, 6wd5:C, 6wd6:C, 6wd7:C, 6wd8:C, 6wd9:C, 6wda:C, 6wdb:C, 6wdc:C, 6wdd:C, 6wde:C, 6wdf:C, 6wdg:C, 6wdh:C, 6wdi:C, 6wdj:C, 6wdk:C, 6wdl:C, 6wdm:C, 5we4:1, 5we6:1, 4wf1:B1, 4wf1:D1, 5wf0:1, 5wfk:1, 5wfs:1, 6wnw:C, 4woi:B1, 4woi:C1, 4www:R1, 4www:Y1, 6x6t:k, 6x7f:k, 6x7k:k, 6x9q:k, 6xdq:k, 6xdr:k, 6xgf:k, 6xii:k, 6xij:k, 6xz7:b, 6xza:b2, 6xzb:b2, 6y69:1, 7y7c:0, 7y7d:0, 7y7e:0, 7y7f:0, 7y7g:0, 7y7h:0, 4ybb:C2, 4ybb:D2, 7yla:j, 6ys3:4, 6ysr:1, 6yss:1, 6yst:1, 6ysu:1, 7z20:4, 7zod:4, 7zp8:4, 7zq5:4, 7zq6:4, 6ztj:B3, 6ztl:B3, 6ztm:B3, 6ztn:B3, 6zto:B3, 6ztp:B3, 7zta:L331, 6zu1:B3
11 3j6b:X 64 48 0.3958 0.2969 0.3958 4.45e-05 5mrc:X, 5mre:X, 5mrf:X
12 8a22:AA 50 47 0.4792 0.4600 0.4894 4.76e-05 8apn:AA, 8apo:AA
13 5dm6:1 54 35 0.3750 0.3333 0.5143 6.01e-05 5dm7:1
14 7m4v:0 51 45 0.2917 0.2745 0.3111 2.23e-04 7m4w:0, 7m4x:0, 7m4y:0, 7m4z:0, 7ryf:0, 7ryg:0, 7ryh:0, 7uvv:0, 7uvw:0, 7uvx:0, 7uvy:0, 7uvz:0, 7uw1:0, 6v39:0, 6v3a:0, 6v3b:0, 6v3d:0, 6yhs:Y, 6ysi:Y
15 8rd8:bk 49 45 0.3125 0.3061 0.3333 4.22e-04 8rdv:bk, 8rdw:bk
16 5b48:B 286 36 0.2917 0.0490 0.3889 0.94
17 8zfk:D 412 15 0.1875 0.0218 0.6000 3.1 8zfk:E, 8zfk:A, 8zfk:B, 8zfk:C
18 3ff6:A 750 27 0.2292 0.0147 0.4074 4.1 3ff6:B, 3ff6:C, 3ff6:D, 3tdc:A
19 8iuf:1A 352 34 0.2292 0.0312 0.3235 7.5 8j9h:1A, 8j9i:1A, 8j9j:1A
20 8ryz:A 405 16 0.1667 0.0198 0.5000 9.6 8k5i:A, 8k5j:A, 8k5k:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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