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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
SIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRL
DLEGTPYKEATAAELADRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFYR
DVLGFRLRDSMRLPPQMVGRPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRKVPMS
ATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLWGHDFTVG

The query sequence (length=296) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2zi8:A 299 296 1.0000 0.9900 1.0000 0.0 2zi8:B, 2zyq:A, 2zyq:B
2 1kmy:A 288 295 0.3953 0.4062 0.3966 1.32e-60 1han:A, 1knd:A, 1knf:A, 1lgt:A, 1lkd:A
3 1eil:A 289 294 0.3682 0.3772 0.3707 5.81e-48 1dhy:A, 1eiq:A, 1eir:A, 1kw3:B, 1kw6:B, 1kw8:B, 1kw9:B, 1kwc:B
4 6l3w:A 298 298 0.3581 0.3557 0.3557 3.05e-46
5 2wl9:A 300 301 0.3378 0.3333 0.3322 6.78e-46 2wl3:A, 2wl3:B, 2wl3:C, 2wl3:D, 2wl9:B, 2wl9:C, 2wl9:D
6 2ehz:A 299 280 0.3074 0.3043 0.3250 1.18e-39 2ei0:A, 2ei1:A, 2ei2:A, 2ei3:A
7 3vb0:A 289 305 0.3142 0.3218 0.3049 3.24e-24 3vb0:B, 3vb0:C, 3vb0:D
8 3b59:A 301 171 0.1520 0.1495 0.2632 1.95e-09 3b59:B, 3b59:C, 3b59:D, 3b59:E, 3b59:F
9 1mpy:A 307 282 0.2027 0.1954 0.2128 6.63e-04 1mpy:B, 1mpy:C, 1mpy:D
10 3hpv:A 297 272 0.1892 0.1886 0.2059 0.007 3hpv:B, 3hpv:C, 3hpv:D, 3hpy:A, 3hpy:B, 3hpy:C, 3hpy:D, 3hq0:A, 3hq0:B, 3hq0:C, 3hq0:D
11 1f1u:A 322 319 0.2534 0.2329 0.2351 0.053 1f1r:A, 1f1r:B, 1f1u:B, 1f1v:A, 1f1v:B
12 1lqk:A 134 27 0.0439 0.0970 0.4815 0.19 1lqk:B, 1lqo:A, 1lqo:B, 1lqp:A, 1lqp:B, 1nki:A, 1nki:B, 1nnr:A, 1nnr:B
13 6qh4:C 138 129 0.0912 0.1957 0.2093 0.44 6qh4:A, 6qh4:B, 6qh4:D, 3rmu:A, 3rmu:B, 3rmu:C, 3rmu:D
14 6go1:A 318 102 0.0980 0.0912 0.2843 0.45 6go1:B
15 7n7g:A 138 25 0.0338 0.0725 0.4000 0.53 7n7g:B
16 7r84:A 52 32 0.0473 0.2692 0.4375 0.65 7r84:C, 7r84:D
17 3b55:A 408 86 0.0845 0.0613 0.2907 1.3
18 5vb0:C 143 31 0.0439 0.0909 0.4194 1.3 5vb0:A, 5vb0:B, 5vb0:D, 5vb0:E, 5vb0:F, 5vb0:G, 5vb0:H, 5wep:A, 5wep:B
19 1zsw:A 328 70 0.0676 0.0610 0.2857 1.8
20 4naz:A 130 23 0.0270 0.0615 0.3478 3.6 4nay:A, 4nb0:A, 4nb0:B, 4nb1:B, 4nb1:A
21 3o7w:A 282 28 0.0405 0.0426 0.4286 4.4
22 3p71:T 315 28 0.0405 0.0381 0.4286 5.0 3iei:A, 3iei:B, 3iei:C, 3iei:D, 3iei:E, 3iei:F, 3iei:G, 3iei:H
23 1uf2:A 967 77 0.0676 0.0207 0.2597 6.6
24 1xrk:B 121 20 0.0405 0.0992 0.6000 6.9 1xrk:A, 2zhp:A, 2zhp:B
25 4los:A 187 97 0.1047 0.1658 0.3196 7.5
26 5umw:B 134 32 0.0372 0.0821 0.3438 8.0 5umw:E, 5umw:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218