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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
SEPLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQ
TEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVL
RSTPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPH
SISLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVDLAKIREVAAREDLYSLLARSIAP
SIYELEDVKKGILLQLFGGTNKTFRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVGLTAYITRVLESG
ALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLL
SRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMTATTRQLE
SMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELI
KQINEHSQDRVESSDIQEALSRLQQEDKVIVLGGVRRSV

The query sequence (length=679) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6skl:4 679 679 1.0000 1.0000 1.0000 0.0 8kg9:4, 8xgc:4
2 8kg8:4 697 701 0.9853 0.9598 0.9544 0.0 8b9a:4, 8b9b:4, 8b9c:4, 8kg6:4, 8p5e:4, 8p62:4, 8p63:4, 7pmk:4, 7pmn:4, 7qhs:4, 6sko:4, 8w7m:4, 7z13:4, 7z13:c
3 5v8f:4 741 743 0.9764 0.8947 0.8923 0.0 5bk4:C, 5bk4:4, 6eyc:4, 6f0l:C, 3ja8:4, 7p30:4, 7p30:C, 7p5z:C, 7p5z:4, 7pt6:4, 7pt6:D, 7pt7:4, 7pt7:D, 6rqc:4, 7v3u:4, 7v3u:D, 7v3v:4, 7v3v:D, 7w8g:4, 7w8g:D
4 8b9d:4 677 705 0.4831 0.4845 0.4652 0.0 7pfo:4, 7plo:4
5 7w1y:4 653 630 0.4610 0.4793 0.4968 0.0 7w1y:C, 6xtx:4, 6xty:4
6 6rax:4 626 636 0.4477 0.4856 0.4780 0.0 6raw:4, 6ray:4, 6raz:4
7 8ouw:4 619 635 0.4153 0.4556 0.4441 0.0
8 4r7y:A 591 613 0.3358 0.3858 0.3719 8.21e-127 4r7y:B, 4r7z:A, 4r7z:B, 4r7z:C, 4r7z:D, 4r7z:E, 4r7z:F, 4r7z:G, 4r7z:H, 4r7z:I, 4r7z:P, 4r7z:J, 4r7z:K, 4r7z:L, 4r7z:M, 4r7z:N, 4r7z:O
9 8x7u:D 654 578 0.3211 0.3333 0.3772 3.98e-119 8x7u:E, 8x7u:C, 8x7u:B, 8x7u:F, 8x7u:A
10 4fdg:B 592 615 0.3137 0.3598 0.3463 4.35e-113 8eaf:A, 8eaf:B, 8eaf:C, 8eaf:D, 8eaf:E, 8eaf:F, 8eag:B, 8eag:C, 8eag:D, 8eag:E, 8eag:F, 8eag:A, 8eah:A, 8eah:B, 8eah:C, 8eah:D, 8eah:E, 8eah:F, 8eai:B, 8eai:C, 8eai:D, 8eai:E, 8eai:F, 8eai:A, 8eaj:A, 8eaj:B, 8eaj:C, 8eaj:D, 8eaj:E, 8eaj:F, 8eak:B, 8eak:C, 8eak:D, 8eak:E, 8eak:A, 8eak:F, 8eal:A, 8eal:B, 8eal:C, 8eal:D, 8eal:E, 8eal:F, 8eam:B, 8eam:C, 8eam:D, 8eam:E, 8eam:A, 8eam:F, 4fdg:A, 4fdg:C, 4fdg:D, 4fdg:E, 6mii:A, 6mii:B, 6mii:C, 6mii:D, 6mii:E, 6mii:F, 2vl6:A, 2vl6:B, 2vl6:C, 6wnz:B, 6wnz:A
11 5u8t:6 661 518 0.2916 0.2995 0.3822 1.97e-108 6wgi:6
12 8ouw:7 632 483 0.2813 0.3022 0.3954 3.72e-108
13 7w1y:2 706 597 0.3063 0.2946 0.3484 4.25e-107 7pfo:2, 7plo:2, 8q6o:A, 8q6o:2, 8q6p:2, 7w1y:A, 6xtx:2, 6xty:2
14 5v8f:6 692 548 0.2975 0.2919 0.3686 1.65e-104 8b9a:6, 8b9b:6, 8b9c:6, 6eyc:6, 3ja8:6, 8kg6:6, 8kg8:6, 8kg9:6, 7p30:6, 7p30:E, 7p5z:6, 7p5z:E, 8p5e:6, 8p62:6, 8p63:6, 7pmk:6, 7pmn:6, 6ptn:m, 6ptn:6, 6pto:l, 6pto:6, 7pt6:6, 7pt6:F, 7pt7:6, 7pt7:F, 6rqc:6, 6skl:6, 6sko:6, 6u0m:6, 5u8s:6, 8w7m:6, 8xgc:6
15 8b9d:7 576 461 0.2872 0.3385 0.4230 5.40e-103
16 6rax:2 605 635 0.2990 0.3355 0.3197 3.29e-102 6raw:2, 6ray:2
17 7w1y:F 643 492 0.2960 0.3126 0.4085 3.49e-102 7w1y:7
18 7v3u:6 646 539 0.2931 0.3080 0.3692 5.19e-102 7qhs:6, 7v3u:F, 7v3v:6, 7v3v:F, 7w8g:6, 7w8g:F, 7z13:6, 7z13:e
19 7plo:7 607 479 0.2916 0.3262 0.4134 1.58e-101 7pfo:7
20 8b9d:2 576 430 0.2563 0.3021 0.4047 7.91e-101
21 7pmn:5 660 648 0.3034 0.3121 0.3179 2.37e-100
22 5v8f:7 725 545 0.3108 0.2910 0.3872 3.25e-100 8b9a:7, 8b9b:7, 8b9c:7, 3jc6:7, 3jc7:7, 8kg6:7, 8kg8:7, 8p5e:7, 8p62:7, 8p63:7, 7pt6:7, 7pt6:G, 7pt7:7, 7pt7:G, 7qhs:7, 6rqc:7, 6sko:7, 8w7m:7, 7z13:7, 7z13:f
23 8p5e:5 695 689 0.3137 0.3065 0.3091 6.27e-100 6eyc:5, 6f0l:D, 6f0l:5, 3ja8:5, 8kg6:5, 8kg8:5, 8kg9:5, 7p30:5, 7p30:D, 7p5z:5, 7p5z:D, 8p62:5, 8p63:5, 7pmk:5, 6ptn:l, 6ptn:5, 6pto:k, 6pto:5, 7pt6:5, 7pt6:E, 7pt7:5, 7pt7:E, 7qhs:5, 6rqc:5, 6skl:5, 6u0m:5, 5u8s:5, 5u8t:5, 7v3u:5, 7v3u:E, 7v3v:5, 7v3v:E, 7w8g:5, 7w8g:E, 8xgc:5, 7z13:5, 7z13:d
24 7v3u:7 699 499 0.3004 0.2918 0.4088 1.21e-99 5bk4:F, 5bk4:7, 6eyc:7, 3ja8:7, 7p30:7, 7p30:F, 7p5z:7, 7p5z:F, 7v3u:G, 7v3v:7, 7v3v:G, 7w8g:7, 7w8g:G
25 6xtx:7 598 486 0.2916 0.3311 0.4074 1.35e-99 6xty:7
26 7pt6:2 629 600 0.2990 0.3227 0.3383 2.02e-98 5bk4:2, 5bk4:A, 6eyc:2, 6f0l:A, 6f0l:2, 3ja8:2, 7p30:2, 7p30:A, 7p5z:2, 7p5z:A, 7pt6:B, 7pt7:2, 7pt7:B, 6rqc:2, 6sko:2, 5u8s:2, 7v3u:2, 7v3u:B, 7v3v:2, 7v3v:B, 5v8f:2, 8w7m:2, 7w8g:2, 7w8g:B
27 6raw:6 601 615 0.3152 0.3561 0.3480 2.39e-98 6raz:6
28 8kg9:7 636 476 0.2931 0.3129 0.4181 7.18e-98 7pmk:7, 7pmn:7, 6skl:7, 8xgc:7
29 8ouw:2 701 660 0.3166 0.3067 0.3258 5.76e-97
30 6hv9:3 558 481 0.2798 0.3405 0.3950 1.41e-96
31 5u8t:2 583 593 0.2931 0.3413 0.3356 2.38e-96
32 8w7m:3 619 496 0.2887 0.3166 0.3952 4.23e-95 8b9a:3, 8b9b:3, 8b9c:3, 7pmk:3, 6skl:3, 8xgc:3
33 6rax:6 628 642 0.3152 0.3408 0.3333 5.97e-95 6ray:6
34 7w1y:5 710 660 0.3181 0.3042 0.3273 1.11e-94 7plo:5, 7w1y:D
35 6raz:7 601 526 0.3078 0.3478 0.3973 3.35e-94 6ray:7
36 5bk4:D 661 660 0.3019 0.3101 0.3106 4.12e-94 5bk4:5
37 6raz:2 559 627 0.2931 0.3560 0.3174 5.70e-94
38 6hv9:5 628 623 0.2975 0.3217 0.3242 1.91e-93
39 8xgc:2 778 631 0.3049 0.2661 0.3281 3.06e-93 8kg6:2, 8kg8:2, 8kg9:2, 8p5e:2, 8p62:2, 8p63:2, 7pmk:2, 7pmn:2, 6ptn:i, 6ptn:2, 6pto:h, 6pto:2, 7qhs:2, 6skl:2, 6u0m:2, 7z13:2, 7z13:a
40 7pfo:5 605 596 0.2975 0.3339 0.3389 2.59e-92 8b9d:5
41 6wgi:3 637 547 0.3004 0.3203 0.3729 3.52e-92
42 6xtx:6 679 498 0.2666 0.2666 0.3635 9.73e-92 8b9d:6, 7pfo:6, 7plo:6, 6xty:6
43 6rax:7 632 501 0.2975 0.3196 0.4032 1.02e-91 6raw:7
44 7pt7:C 633 520 0.2872 0.3081 0.3750 4.09e-91
45 8ouw:3 619 427 0.2474 0.2714 0.3934 8.64e-91
46 8b9d:3 569 594 0.3034 0.3620 0.3468 1.18e-90
47 6xtx:3 608 611 0.3063 0.3421 0.3404 3.11e-90
48 8p5e:3 649 528 0.2872 0.3005 0.3693 8.38e-90 8kg6:3, 8kg8:3, 8kg9:3, 8p62:3, 8p63:3, 7pt6:3, 7pt6:C, 7pt7:3, 7qhs:3, 7v3u:3, 7v3u:C, 7v3v:3, 7v3v:C, 7w8g:3, 7w8g:C, 7z13:3, 7z13:b
49 6rax:5 620 622 0.2946 0.3226 0.3215 1.92e-89 6ray:5, 6raz:5
50 7w1y:6 716 532 0.2739 0.2598 0.3496 4.01e-89 7w1y:E
51 8b9a:5 533 599 0.2754 0.3508 0.3122 1.10e-88 8b9b:5, 8b9c:5, 6sko:5
52 5v8f:3 654 562 0.2946 0.3058 0.3559 3.17e-88 5bk4:B, 5bk4:3, 6eyc:3, 6f0l:3, 6f0l:B, 3ja8:3, 7p30:3, 7p30:B, 7p5z:3, 7p5z:B, 6ptn:j, 6ptn:3, 6pto:i, 6pto:3, 6rqc:3, 6sko:3, 6u0m:3, 5u8s:3, 5u8t:3
53 7plo:3 628 621 0.3034 0.3280 0.3317 6.89e-87 7pfo:3
54 6hv9:2 549 578 0.2901 0.3588 0.3408 2.40e-86
55 6raw:5 576 610 0.2960 0.3490 0.3295 1.01e-85
56 8ouw:6 707 642 0.3063 0.2942 0.3240 1.02e-84
57 7w1y:B 651 645 0.3049 0.3180 0.3209 6.00e-84 7w1y:3
58 6ray:3 600 427 0.2445 0.2767 0.3888 5.63e-83 6raw:3, 6raz:3
59 6xtx:5 577 582 0.2769 0.3258 0.3230 2.49e-81 6xty:5
60 8ouw:5 541 602 0.2828 0.3549 0.3189 4.54e-80
61 8q6p:5 321 324 0.2077 0.4393 0.4352 4.64e-80
62 6rax:3 625 444 0.2430 0.2640 0.3716 2.34e-79
63 8q6p:3 370 361 0.2180 0.4000 0.4100 2.58e-78
64 8s91:A 602 549 0.2548 0.2874 0.3151 7.39e-78 7dp3:A, 8s91:B, 8s91:C, 8s94:A, 8s94:C, 8s94:B
65 8w7m:5 529 598 0.2636 0.3384 0.2993 3.91e-77
66 7wi7:A 565 529 0.2518 0.3027 0.3233 5.92e-76
67 8q6p:6 395 319 0.1973 0.3392 0.4201 9.06e-76
68 8b9a:2 568 597 0.2651 0.3169 0.3015 6.50e-75 8b9b:2, 8b9c:2
69 8q6o:C 258 289 0.1797 0.4729 0.4221 3.00e-73 8q6o:4
70 8s91:D 621 545 0.2622 0.2866 0.3266 2.95e-72 7dpd:A, 7dpd:B, 8s91:E, 8s91:F, 8s94:D, 8s94:F, 8s94:E
71 8q6p:7 298 301 0.2121 0.4832 0.4784 3.27e-70
72 7wi7:B 566 546 0.2563 0.3074 0.3187 7.39e-65
73 1ltl:E 242 209 0.0839 0.2355 0.2727 4.39e-16 1ltl:A, 1ltl:B, 1ltl:C, 1ltl:D, 1ltl:F
74 4pof:A 255 215 0.0825 0.2196 0.2605 1.53e-15 5iy0:A, 5iy0:B, 5iy0:C, 5iy0:D, 5iy0:E, 5iy0:F, 4pof:B, 4pof:C, 4pof:D, 4pof:E, 4pof:F, 4pog:A, 4pog:E, 4pog:F, 4pog:K, 4pog:L, 4pog:G, 4pog:H, 4pog:I, 4pog:J, 4pog:B, 4pog:C, 4pog:D, 4ywl:A, 4ywl:B, 4ywl:C, 4ywl:D, 4ywl:E, 4ywl:F, 4ywl:G, 4ywl:H, 4ywl:I, 4ywl:J, 4ywm:A, 4ywm:B, 4ywm:C, 4ywm:D, 4ywm:E, 4ywm:F, 4ywm:G, 4ywm:H, 4ywm:I, 4ywm:J
75 8q6o:E 249 130 0.0589 0.1606 0.3077 3.73e-13 8q6o:6
76 8q6o:D 256 259 0.0884 0.2344 0.2317 8.47e-10 8q6o:5
77 8q6o:F 275 129 0.0574 0.1418 0.3023 4.77e-09 8q6o:7
78 4me3:A 246 185 0.0692 0.1911 0.2541 5.07e-09
79 7vno:A 452 125 0.0427 0.0642 0.2320 0.25 7vno:B, 7vnt:A, 7vnt:B, 7vo1:A, 7vo1:B
80 8osg:B 323 90 0.0339 0.0712 0.2556 1.5 8osf:A, 8osf:B, 8osf:C, 8osf:D, 8osf:E, 8osg:C, 8osg:D, 8osg:E
81 6vfx:E 341 59 0.0265 0.0528 0.3051 1.9 6vfs:E, 6vfs:C, 6vfs:D, 6vfx:C, 6vfx:B, 6vfx:D, 6vfx:A
82 6n2i:A 338 189 0.0633 0.1272 0.2275 2.0
83 6v11:C 503 197 0.0648 0.0875 0.2234 2.7 6v11:A, 6v11:B, 6v11:F
84 6tly:A 99 55 0.0236 0.1616 0.2909 3.8
85 3ug7:A 317 70 0.0280 0.0599 0.2714 3.9 3ug6:A, 3ug6:B, 3ug6:C, 3ug6:D, 3ug7:B, 3ug7:C, 3ug7:D
86 3k1j:A 566 67 0.0324 0.0389 0.3284 5.4 3k1j:B
87 7rci:A 317 46 0.0221 0.0473 0.3261 6.4 1ea6:A, 1ea6:B, 1h7u:B, 1h7u:A, 7rci:B, 7rck:A, 7rck:B
88 4aie:A 537 77 0.0324 0.0410 0.2857 6.4
89 8h1c:B 983 170 0.0707 0.0488 0.2824 7.4 8h1c:A, 7xjz:A, 7xk0:A, 7xk1:A, 7xk1:C
90 3zkn:A 375 48 0.0280 0.0507 0.3958 8.5 7d5b:A, 7d5u:A, 2ewy:A, 2ewy:B, 2ewy:C, 2ewy:D, 7f1g:A, 6jsz:A, 7n4n:A, 6uj0:A, 6uj0:B, 6uj1:A, 6uj1:B, 3zki:A, 3zki:B, 3zkn:B, 3zks:A, 3zlq:A, 3zlq:B
91 6uv1:A 438 86 0.0339 0.0525 0.2674 9.8 6uv1:B, 6uv2:A, 6uv3:A, 6uv4:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218