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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
SASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVF
SFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYITQEAPRPPATVTNAVSWRSEGIKYRK
NEVFLDVIEAVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFE
NDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMVKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTT
VGSVKWVPENSEIVWSVKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQALPW
VRYITQNGDYQLRTQ

The query sequence (length=415) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6cm9:M 415 415 1.0000 1.0000 1.0000 0.0 6cri:M, 6cri:W, 6cri:X, 8d4c:M, 8d4c:J, 8d4d:M, 8d4d:J, 8d4e:M, 8d4f:M, 8d4f:J, 8d4g:M, 8d4g:J, 6d83:M, 6d84:M, 6d84:P, 8d9r:M, 8d9r:j, 8d9r:k, 8d9r:l, 8d9r:m, 8d9r:n, 8d9s:M, 8d9s:j, 8d9s:k, 8d9s:l, 8d9s:m, 8d9s:n, 8d9t:M, 8d9t:i, 8d9t:j, 8d9t:k, 8d9t:l, 8d9t:m, 8d9u:M, 8d9u:i, 8d9u:j, 8d9u:k, 8d9u:l, 8d9u:m, 8d9v:M, 8d9v:J, 6dff:M, 4emz:M, 4emz:A, 4en2:M, 4en2:A, 4p6z:M, 7ux3:M
2 8d9w:a 322 412 0.7759 1.0000 0.7816 0.0 8d9w:M
3 2xa7:M 428 428 0.4024 0.3902 0.3902 8.71e-108 5c7z:A, 5fpi:A, 7oiq:AAA, 7oit:AAA, 6qh6:M, 6qh7:M, 8t1o:M, 5wrl:A, 5wrm:A, 6yaf:M
4 7og1:MMM 406 419 0.3976 0.4064 0.3938 7.65e-107 6bnt:A, 2bp5:M, 1bw8:A, 1bxx:A, 3h85:A, 1hes:A, 1i31:A, 7oiq:BBB, 2pr9:A, 5wrk:A
5 7rwa:M 379 416 0.3783 0.4142 0.3774 3.14e-96 7rwa:m
6 1h6e:A 219 264 0.2241 0.4247 0.3523 3.99e-44
7 4ikn:A 249 270 0.1976 0.3293 0.3037 5.89e-35
8 3l81:A 250 259 0.1831 0.3040 0.2934 6.84e-31 4mdr:A
9 3mc6:A 426 93 0.0578 0.0563 0.2581 0.80 3mc6:C
10 5o3w:B 717 76 0.0530 0.0307 0.2895 1.5 5o3u:A, 5o3u:B, 5o3u:C, 5o3u:D, 5o3v:B, 5o3v:A, 5o3w:A, 5o3w:C, 5o3w:D, 5uw3:A, 5uw3:B, 5uw3:C, 5uw5:A, 5uw5:B, 5uw5:C, 5uw6:A, 5uw6:B, 5uw6:C, 5uzw:A, 5uzw:B, 5uzw:C
11 5uw3:D 698 76 0.0506 0.0301 0.2763 4.1 5uw5:D, 5uw6:D, 5uw7:A, 5uw7:B, 5uzw:D
12 6cm9:S 142 76 0.0458 0.1338 0.2500 4.2 8d4c:S, 8d4c:O, 8d4d:S, 8d4d:O, 8d4e:S, 8d4f:S, 8d4f:O, 8d4g:S, 8d4g:O, 6d83:S, 6d84:S, 6d84:Q, 8d9r:S, 8d9r:t, 8d9r:u, 8d9r:v, 8d9r:w, 8d9r:x, 8d9s:S, 8d9s:t, 8d9s:u, 8d9s:v, 8d9s:w, 8d9s:x, 8d9t:S, 8d9t:s, 8d9t:t, 8d9t:u, 8d9t:v, 8d9t:w, 8d9u:S, 8d9u:s, 8d9u:t, 8d9u:u, 8d9u:v, 8d9u:w, 8d9v:S, 8d9v:O, 8d9w:e, 8d9w:f, 6dff:S, 7r4h:S, 7ux3:S
13 2hox:B 427 130 0.0819 0.0796 0.2615 5.9 2hor:A, 2hox:C, 2hox:A, 2hox:D, 1lk9:B, 1lk9:A
14 7l0b:A 202 41 0.0361 0.0743 0.3659 8.2 7l0b:B, 7l0b:C, 7l0b:D
15 2vgq:A 461 64 0.0386 0.0347 0.2500 8.3
16 8jiw:BE 263 31 0.0313 0.0494 0.4194 8.8 8auv:A, 8b2l:A1, 8ip8:ja, 8ip9:ja, 8ipa:ja, 8ipb:ja, 8r6f:E, 4v3p:SD, 4v7e:BE
17 2jkr:S 142 57 0.0361 0.1056 0.2632 9.3 2jkr:I, 2jkt:S, 2jkt:I, 7og1:SSS, 6qh6:S, 6qh7:S

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218