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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
RRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQM
HGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFD
LSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRD
YLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGF
REVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDE
ANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGAD
TTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRPLILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVD
QSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQFRLSGQTIEVTSEYLFRHSDNELL
HWMVALDGKPLASGEVPLDVAPQGKQLIELPELPQPESAGQLWLTVRVVQPNATAWSEAGHISAWQQWRLAENLSVTLPA
ASHAIPHLTTSEMDFCIELGNKRWQFNRQSGFLSQMWIGDKKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKA
AGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFISRKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQLAQVA
ERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSH
RHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGRYHYQLVWCQK

The query sequence (length=1011) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 7btk:C 1023 1011 0.9990 0.9873 0.9990 0.0 5a1a:A, 5a1a:B, 5a1a:C, 5a1a:D, 7brs:A, 7brs:B, 7brs:C, 7brs:D, 7btk:A, 7btk:B, 7btk:D, 6cvm:A, 6cvm:B, 6cvm:C, 6cvm:D, 3czj:A, 3czj:B, 3czj:C, 3czj:D, 1dp0:A, 1dp0:B, 1dp0:C, 1dp0:D, 4duv:A, 4duv:B, 4duv:C, 4duv:D, 4duw:A, 4duw:B, 4duw:C, 4duw:D, 4dux:A, 4dux:B, 4dux:C, 4dux:D, 3dym:A, 3dym:B, 3dym:C, 3dym:D, 3dyo:A, 3dyo:B, 3dyo:C, 3dyo:D, 3dyp:A, 3dyp:B, 3dyp:C, 3dyp:D, 3e1f:1, 3e1f:2, 3e1f:3, 3e1f:4, 1f4a:A, 1f4a:B, 1f4a:C, 1f4a:D, 1f4h:A, 1f4h:B, 1f4h:C, 1f4h:D, 1hn1:A, 1hn1:B, 1hn1:C, 1hn1:D, 3i3b:A, 3i3b:B, 3i3b:C, 3i3b:D, 3i3d:A, 3i3d:B, 3i3d:C, 3i3d:D, 3i3e:A, 3i3e:B, 3i3e:C, 3i3e:D, 3iap:A, 3iap:B, 3iap:C, 3iap:D, 3iaq:A, 3iaq:B, 3iaq:C, 3iaq:D, 3j7h:A, 3j7h:B, 3j7h:C, 3j7h:D, 1jyn:A, 1jyn:B, 1jyn:C, 1jyn:D, 1jyv:A, 1jyv:B, 1jyv:C, 1jyv:D, 1jyw:A, 1jyw:B, 1jyw:C, 1jyw:D, 1jyx:A, 1jyx:B, 1jyx:C, 1jyx:D, 1jz2:A, 1jz2:B, 1jz2:C, 1jz2:D, 1jz3:A, 1jz3:B, 1jz3:C, 1jz3:D, 1jz4:A, 1jz4:B, 1jz4:C, 1jz4:D, 1jz5:A, 1jz5:B, 1jz5:C, 1jz5:D, 1jz6:A, 1jz6:B, 1jz6:C, 1jz6:D, 1jz7:A, 1jz7:B, 1jz7:C, 1jz7:D, 1jz8:A, 1jz8:B, 1jz8:C, 1jz8:D, 6kuz:A, 6kuz:B, 6kuz:C, 6kuz:D, 3muy:1, 3muy:2, 3muy:3, 3muy:4, 3muz:1, 3muz:2, 3muz:3, 3muz:4, 3mv0:1, 3mv0:2, 3mv0:3, 3mv0:4, 3mv1:1, 3mv1:2, 3mv1:3, 3mv1:4, 1px3:A, 1px3:B, 1px3:C, 1px3:D, 1px4:A, 1px4:B, 1px4:C, 1px4:D, 3sep:A, 3sep:B, 3sep:C, 3sep:D, 3t08:A, 3t08:B, 3t08:C, 3t08:D, 3t09:A, 3t09:B, 3t09:C, 3t09:D, 3t0a:A, 3t0a:B, 3t0a:C, 3t0a:D, 3t0b:A, 3t0b:B, 3t0b:C, 3t0b:D, 3t0d:A, 3t0d:B, 3t0d:C, 3t0d:D, 3t2o:A, 3t2o:B, 3t2o:C, 3t2o:D, 3t2p:A, 3t2p:B, 3t2p:C, 3t2p:D, 3t2q:A, 3t2q:B, 3t2q:C, 3t2q:D, 6tsh:A, 6tsh:B, 6tsh:C, 6tsh:D, 6tsk:A, 6tsk:B, 6tsk:C, 6tsk:D, 4ttg:A, 4ttg:B, 4ttg:C, 4ttg:D, 6tte:A, 6tte:B, 6tte:C, 6tte:D, 4v40:A, 4v40:B, 4v40:C, 4v40:D, 4v40:E, 4v40:F, 4v40:G, 4v40:H, 4v40:I, 4v40:J, 4v40:K, 4v40:L, 4v40:M, 4v40:N, 4v40:O, 4v40:P, 4v41:A, 4v41:B, 4v41:C, 4v41:D, 4v41:E, 4v41:F, 4v41:G, 4v41:H, 4v41:I, 4v41:J, 4v41:K, 4v41:L, 4v41:M, 4v41:N, 4v41:O, 4v41:P, 4v44:A, 4v44:B, 4v44:C, 4v44:D, 4v44:E, 4v44:F, 4v44:G, 4v44:H, 4v44:I, 4v44:J, 4v44:K, 4v44:L, 4v44:M, 4v44:N, 4v44:O, 4v44:P, 4v45:A, 4v45:B, 4v45:C, 4v45:D, 4v45:E, 4v45:F, 4v45:G, 4v45:H, 4v45:I, 4v45:J, 4v45:K, 4v45:L, 4v45:M, 4v45:N, 4v45:O, 4v45:P, 3vd3:A, 3vd3:B, 3vd3:C, 3vd3:D, 3vd4:A, 3vd4:B, 3vd4:C, 3vd4:D, 3vd5:A, 3vd5:C, 3vd5:D, 3vd5:B, 3vd7:A, 3vd7:B, 3vd7:C, 3vd7:D, 3vd9:A, 3vd9:B, 3vd9:C, 3vd9:D, 3vda:A, 3vda:B, 3vda:C, 3vda:D, 3vdb:A, 3vdb:B, 3vdb:C, 3vdb:D, 3vdc:A, 3vdc:B, 3vdc:C, 3vdc:D, 8vt0:A, 8vt0:B, 8vt0:C, 8vt0:D, 6x1q:A, 6x1q:B, 6x1q:C, 6x1q:D
2 6s6z:A 1083 1024 0.3660 0.3416 0.3613 0.0 6s6z:D, 6s6z:B, 6s6z:H, 6s6z:F, 6s6z:G, 6s6z:E, 6s6z:C, 6sd0:A, 6sd0:B, 6sd0:C, 6sd0:D
3 3bga:A 1003 1012 0.3363 0.3390 0.3360 2.50e-169 3bga:B
4 6se9:A 989 1026 0.3561 0.3640 0.3509 2.86e-156 6sea:A, 6seb:A, 6sec:A, 6sed:A, 6zjq:A, 6zjr:A, 6zjs:A, 6zjt:A, 6zju:A, 6zjw:A, 6zjx:A
5 1yq2:A 1020 1027 0.3373 0.3343 0.3320 6.66e-147 1yq2:B, 1yq2:C, 1yq2:D, 1yq2:E, 1yq2:F
6 3ob8:A 1024 1029 0.3096 0.3057 0.3042 5.88e-139 3ob8:B, 3ob8:D, 3ob8:C, 3oba:A, 3oba:C, 3oba:D, 3oba:B
7 7kgy:A 593 468 0.1276 0.2175 0.2756 3.72e-33 7kgy:B, 7kgy:C, 7kgy:D
8 5z1b:A 627 478 0.1256 0.2026 0.2657 5.82e-32 6ld0:A, 6ld0:B, 6ld0:C, 6ld0:D, 6ldb:A, 6ldb:B, 6ldb:C, 6ldb:D, 6ldc:A, 6ldc:B, 6ldc:C, 6ldc:D, 6ldd:A, 6ldd:B, 6ldd:C, 6ldd:D, 5z1b:B, 5z1b:C, 5z1b:D
9 6ed2:A 591 468 0.1236 0.2115 0.2671 8.22e-31
10 5t99:A 757 457 0.1246 0.1664 0.2757 4.51e-30 5t99:B
11 1bhg:A 611 416 0.1128 0.1866 0.2740 6.75e-29 1bhg:B, 3hn3:A, 3hn3:B, 3hn3:D, 3hn3:E
12 7nit:D 1253 408 0.1098 0.0886 0.2721 7.15e-29 5dmy:A, 5dmy:B, 5dmy:C, 7nit:A, 7nit:B, 7nit:C, 7nit:E, 7nit:F, 6qub:A, 6qub:B, 6quc:A, 6quc:B
13 3lpf:A 603 484 0.1276 0.2139 0.2665 7.64e-29 5czk:A, 5czk:B, 4jhz:A, 4jhz:B, 3k4d:A, 3k4d:B, 6leg:A, 6leg:B, 6leg:C, 6leg:D, 6lej:A, 6lej:B, 6lel:A, 6lel:B, 6lem:A, 6lem:B, 3lpf:B, 3lpg:A, 3lpg:B, 8ohx:AAA, 8ohx:BBB, 7pr6:AAA, 7pr6:BBB
14 6qud:A 837 392 0.1068 0.1290 0.2755 1.14e-28
15 6u7j:A 569 462 0.1118 0.1986 0.2446 1.79e-28 6u7j:C, 6u7j:D
16 6cxs:B 599 397 0.1068 0.1803 0.2720 2.02e-28 6cxs:A
17 6ncx:B 559 399 0.1137 0.2057 0.2882 1.17e-27 6ncx:D, 6ncx:A, 6ncx:C
18 4jkl:A 587 293 0.0841 0.1448 0.2901 4.92e-27 4jkl:B
19 6ncz:C 589 428 0.0979 0.1681 0.2313 2.40e-26 6ncz:A, 6ncz:B, 6ncz:D, 6ncz:E, 6ncz:F
20 6jz4:A 576 484 0.1227 0.2153 0.2562 4.58e-26 6jz5:A, 6jz5:B, 6jz7:A, 6jz7:B, 6jz8:B
21 5c71:A 583 382 0.0969 0.1681 0.2565 1.23e-25 5c71:C
22 5t9g:C 811 549 0.1316 0.1640 0.2423 3.66e-25 5t9g:A, 5t9g:B, 5t9g:D
23 5z19:B 601 499 0.1217 0.2047 0.2465 5.34e-25 6jz2:A, 6jz2:B, 6jz3:A, 6jz3:B, 6jz4:B, 6jz6:A, 6jz6:B, 6jz8:A, 5z19:A, 5z19:C, 5z19:D, 5z19:E, 5z19:F
24 5z1a:A 655 355 0.0900 0.1389 0.2563 4.90e-24
25 6d41:B 579 337 0.0890 0.1554 0.2671 9.24e-23 6d41:A, 6d6w:A, 6d6w:B, 6d6w:C, 6d6w:D, 6d7f:A, 6d7f:B, 6d7f:C, 6d7f:D, 6d7f:E, 6d7f:F
26 7cwd:A 803 416 0.1068 0.1345 0.2596 5.01e-22
27 8e72:B 598 477 0.1118 0.1890 0.2369 1.68e-21 8dhw:A, 8dhw:B, 8e72:A
28 7vqm:A 584 346 0.0890 0.1541 0.2601 2.93e-21 7vqm:B, 7vqm:C, 7vqm:D
29 6d50:B 840 441 0.1039 0.1250 0.2381 3.86e-21 6d50:A, 6nzg:A, 6nzg:B, 5uj6:A, 5uj6:B
30 6d7j:A 799 265 0.0722 0.0914 0.2755 9.42e-21 6d7j:D
31 4cu7:A 848 466 0.1177 0.1403 0.2554 1.54e-20 4cu8:A, 4cuc:A
32 6bjq:A 598 549 0.1355 0.2291 0.2495 2.98e-20 6d4o:A, 8gen:A, 8geo:A, 8geq:A, 8ger:A, 8ugt:A
33 5ldr:A 731 433 0.1157 0.1601 0.2702 1.62e-19 5ldr:B
34 8dhl:B 853 341 0.0900 0.1067 0.2669 1.58e-18 8dhl:A
35 7xyr:A 546 419 0.0979 0.1813 0.2363 2.59e-17
36 6mvf:A 643 444 0.1009 0.1586 0.2297 1.91e-16 6mvf:B, 6mvf:C, 6mvf:D, 6mvf:E, 6mvf:F
37 6mvg:A 637 404 0.0989 0.1570 0.2475 1.92e-16 6mvg:B, 6mvg:C
38 6bo6:A 493 236 0.0682 0.1400 0.2924 1.01e-14
39 7kgz:B 634 361 0.0841 0.1341 0.2355 1.26e-12 7kgz:A
40 8get:C 659 327 0.0772 0.1184 0.2385 2.14e-12 8ges:A, 8ges:D, 8ges:C, 8ges:B, 8get:A, 8get:B, 8get:D, 6mvh:A, 6mvh:B, 6mvh:C
41 2vl4:B 841 398 0.0989 0.1189 0.2513 4.51e-11 7op6:A, 7op6:B, 7op7:A, 7op7:B, 2vjx:A, 2vjx:B, 2vl4:A, 2vmf:A, 2vmf:B, 2vo5:A, 2vo5:B, 2vot:A, 2vot:B, 2vqt:A, 2vqt:B, 2vqu:A, 2vqu:B, 2vr4:A, 2vr4:B, 2wbk:A, 2wbk:B
42 7sf2:A 586 409 0.1009 0.1741 0.2494 2.52e-10 7sf2:B, 7sf2:C, 7sf2:D, 7sf2:E, 7sf2:F
43 6hpd:A 955 364 0.0722 0.0764 0.2005 5.16e-10
44 5n6u:A 811 399 0.0851 0.1060 0.2155 5.63e-10 5n6u:B, 5n6u:C, 5n6u:D
45 6bye:A 861 444 0.0920 0.1080 0.2095 8.16e-09 6bye:B, 6byg:A, 6byg:B, 6byi:A, 6byi:B
46 6ddt:A 862 160 0.0435 0.0510 0.2750 8.73e-07 6ddu:A
47 2vzs:A 857 373 0.0861 0.1015 0.2332 4.03e-05 2vzs:B, 2vzt:A, 2vzt:B, 2vzu:A, 2vzu:B, 2vzv:A, 2vzv:B, 2x05:A, 2x05:B, 2x09:A, 2x09:B
48 8pe1:B 451 140 0.0307 0.0687 0.2214 0.090 8pe1:A, 8pe2:A
49 2io4:B 246 55 0.0208 0.0854 0.3818 0.77 2io4:D
50 5zov:A 399 79 0.0247 0.0627 0.3165 1.1 5zov:B
51 4dns:A 486 94 0.0267 0.0556 0.2872 5.0 4dns:B
52 5jbx:B 261 113 0.0317 0.1226 0.2832 6.4 5jbx:A
53 7vp2:A 83 44 0.0148 0.1807 0.3409 9.3 7vp1:A, 7vp1:B, 7vp2:B, 7vp4:B, 7vp4:A, 7vp4:F, 7vp4:E, 7vp4:J, 7vp4:I, 7vp5:A, 7vp5:B, 7vp5:E, 7vp5:F, 7vp5:I, 7vp5:J, 7vp7:A, 7vp7:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218