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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
RPFEFRTSVVVSTLLGLVMALLIHFVVLSSGAFNWLR

The query sequence (length=37) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8iug:3 39 37 1.0000 0.9487 1.0000 2.73e-20 8hju:9, 8hju:1, 8hju:3, 8hju:5, 8hju:7, 8hju:A, 8hju:D, 8hju:F, 8hju:H, 8hju:J, 8hju:N, 8hju:P, 8hju:R, 8hju:T, 8hju:V, 8hjv:9, 8hjv:1, 8hjv:3, 8hjv:5, 8hjv:7, 8hjv:A, 8hjv:D, 8hjv:F, 8hjv:H, 8hjv:J, 8hjv:N, 8hjv:P, 8hjv:R, 8hjv:T, 8hjv:V, 8iug:9, 8iug:1, 8iug:5, 8iug:7, 8iug:A, 8iug:D, 8iug:F, 8iug:H, 8iug:J, 8iug:R, 8iug:N, 8iug:P, 8iug:T, 8iug:V, 8iun:V, 8iun:T, 8iun:R, 8iun:P, 8iun:N, 8iun:J, 8iun:H, 8iun:F, 8iun:D, 8iun:A, 8iun:9, 8iun:7, 8iun:5, 8iun:1, 8iun:3, 8j5o:9, 8j5o:1, 8j5o:3, 8j5o:5, 8j5o:7, 8j5o:A, 8j5o:D, 8j5o:F, 8j5o:H, 8j5o:J, 8j5o:R, 8j5o:T, 8j5o:N, 8j5o:P, 8j5o:V, 8j5p:V, 8j5p:9, 8j5p:1, 8j5p:3, 8j5p:5, 8j5p:7, 8j5p:A, 8j5p:D, 8j5p:F, 8j5p:H, 8j5p:J, 8j5p:P, 8j5p:N, 8j5p:R, 8j5p:T, 5yq7:D, 5yq7:A, 5yq7:9, 5yq7:7, 5yq7:3, 5yq7:1, 5yq7:J, 5yq7:V, 5yq7:T, 5yq7:R, 5yq7:P, 5yq7:N, 5yq7:H, 5yq7:F, 5yq7:5
2 7vrj:7 44 34 0.4595 0.3864 0.5000 6.76e-04 7vrj:A, 7vrj:9, 7vrj:I, 7vrj:K, 7vrj:O, 7vrj:Q, 7vrj:1, 7vrj:5, 8wdu:7, 8wdu:9, 8wdu:O, 8wdu:A, 8wdu:I, 8wdu:K, 8wdu:Q, 8wdu:1, 8wdu:5, 8wdv:7, 8wdv:O, 8wdv:A, 8wdv:9, 8wdv:I, 8wdv:K, 8wdv:Q, 8wdv:1, 8wdv:5
3 7oy8:8 48 35 0.4324 0.3333 0.4571 8.23e-04 7eqd:A, 7eqd:D, 7eqd:9, 7eqd:F, 7eqd:I, 7eqd:K, 7eqd:O, 7eqd:Q, 7eqd:S, 7eqd:U, 7eqd:W, 7eqd:Y, 7eqd:1, 7eqd:3, 7eqd:5, 7eqd:7, 7oy8:Z, 7oy8:X, 7oy8:2, 7oy8:4, 7oy8:6, 7oy8:D, 7oy8:A, 7oy8:E, 7oy8:F, 7oy8:G, 7oy8:J, 7oy8:N, 7oy8:R, 7oy8:T, 7oy8:V
4 7xxf:S 58 34 0.4324 0.2759 0.4706 0.001 7xxf:9, 7xxf:D, 7xxf:A, 7xxf:F, 7xxf:I, 7xxf:K, 7xxf:O, 7xxf:Q, 7xxf:U, 7xxf:W, 7xxf:Y, 7xxf:1, 7xxf:3, 7xxf:5, 7xxf:7
5 7yml:D 56 34 0.3784 0.2500 0.4118 0.013 8b64:a, 8b64:e, 8b64:d, 8b64:b, 8b64:f, 8b64:t, 8b64:u, 8b64:s, 8b64:r, 8b64:o, 8b64:n, 8b64:k, 8b64:j, 8b64:i, 8b64:g, 7yml:A, 7yml:F, 7yml:I, 7yml:K, 7yml:O, 7yml:Q, 7yml:S, 7yml:V, 7yml:Y
6 6z5r:T 48 34 0.3514 0.2708 0.3824 0.016 6z5r:C, 6z5r:E, 6z5r:A, 6z5r:G, 6z5r:J, 6z5r:N, 6z5r:P, 6z5r:9, 6z5r:R, 6z5r:V, 6z5r:Y, 6z5r:1, 6z5r:3, 6z5r:5, 6z5r:7, 6z5s:R, 6z5s:1, 6z5s:Y, 6z5s:3, 6z5s:5, 6z5s:V, 6z5s:T, 6z5s:A, 6z5s:C, 6z5s:E, 6z5s:P, 6z5s:N, 6z5s:J, 6z5s:G
7 8k5o:w 63 34 0.3514 0.2063 0.3824 0.017 8k5o:Y, 8k5o:b, 8k5o:k, 8k5o:n, 8k5o:t, 8k5o:z, 8k5o:6, 8k5o:F, 8k5o:K, 8k5o:P, 8k5o:S, 8k5o:V, 8k5o:e, 8k5o:h, 8k5o:q
8 8k5o:3 51 35 0.2703 0.1961 0.2857 0.066
9 7vrj:3 65 34 0.3243 0.1846 0.3529 0.080 8wdu:3, 8wdv:3
10 7pil:AB 55 35 0.2973 0.2000 0.3143 0.097 7f0l:A, 7f0l:D, 7f0l:F, 7f0l:I, 7f0l:K, 7f0l:O, 7f0l:Q, 7f0l:S, 7f0l:V, 7f0l:Y, 7f0l:1, 7f0l:3, 7f0l:5, 7f0l:7, 7pil:AA, 7pil:AC, 7pil:AD, 7pil:AE, 7pil:AF, 7pil:AG, 7pil:AH, 7pil:AI, 7pil:AJ, 7pil:AK, 7pil:AL, 7pil:AM, 7pil:AN, 7pqd:AA, 7pqd:AB, 7pqd:AC, 7pqd:AD, 7pqd:AE, 7pqd:AF, 7pqd:AG, 7pqd:AH, 7pqd:AI, 7pqd:AJ, 7pqd:AK, 7pqd:AL, 7pqd:AM, 7pqd:AN, 7pqd:aa, 7pqd:ab, 7pqd:ac, 7pqd:ad, 7pqd:ae, 7pqd:af, 7pqd:ag, 7pqd:ah, 7pqd:ai, 7pqd:aj, 7pqd:ak, 7pqd:al, 7pqd:am, 7pqd:an, 4v9g:AT, 4v9g:AV, 4v9g:A3, 4v9g:A7, 4v9g:AD, 4v9g:AF, 4v9g:A1, 4v9g:AJ, 4v9g:A2, 4v9g:AN, 4v9g:AP, 4v9g:AZ, 4v9g:A5, 4v9g:AX, 4v9g:B5, 4v9g:BT, 4v9g:BV, 4v9g:B3, 4v9g:B7, 4v9g:BD, 4v9g:BF, 4v9g:B1, 4v9g:B2, 4v9g:BP, 4v9g:BZ, 4v9g:BN, 4v9g:BX, 4v9g:BJ, 7va9:A, 7va9:9, 7va9:D, 7va9:F, 7va9:I, 7va9:K, 7va9:O, 7va9:Q, 7va9:S, 7va9:U, 7va9:W, 7va9:Y, 7va9:1, 7va9:7, 7va9:a, 7va9:3, 7va9:d, 7va9:f, 7va9:i, 7va9:k, 7va9:o, 7va9:q, 7va9:s, 7va9:u, 7va9:w, 7va9:y, 7va9:5, 7va9:6, 7vb9:A, 7vb9:9, 7vb9:D, 7vb9:F, 7vb9:I, 7vb9:K, 7vb9:O, 7vb9:7, 7vb9:a, 7vb9:d, 7vb9:f, 7vb9:i, 7vb9:k, 7vb9:o, 7vb9:q, 7vb9:s, 7vb9:u, 7vb9:w, 7vb9:y, 7vb9:5, 7vb9:6, 7vb9:Q, 7vnm:A, 7vnm:9, 7vnm:D, 7vnm:F, 7vnm:I, 7vnm:O, 7vnm:K, 7vnm:Q, 7vnm:S, 7vnm:U, 7vnm:W, 7vnm:7, 7vnm:1, 7vny:A, 7vny:D, 7vny:9, 7vny:F, 7vny:I, 7vny:K, 7vny:O, 7vny:Q, 7vny:S, 7vny:U, 7vny:W, 7vny:3, 7vny:1, 7vny:7, 7vor:A, 7vor:9, 7vor:D, 7vor:F, 7vor:I, 7vor:K, 7vor:O, 7vor:Q, 7vor:S, 7vor:U, 7vor:W, 7vor:3, 7vor:1, 7vor:7, 7vor:a, 7vor:b9, 7vor:d, 7vor:f, 7vor:i, 7vor:k, 7vor:o, 7vor:q, 7vor:s, 7vor:u, 7vor:w, 7vor:5, 7vor:b1, 7vor:6, 7vot:A, 7vot:9, 7vot:D, 7vot:F, 7vot:I, 7vot:K, 7vot:O, 7vot:Q, 7vot:S, 7vot:U, 7vot:W, 7vot:3, 7vot:1, 7vot:7, 7vot:a, 7vot:b9, 7vot:d, 7vot:f, 7vot:i, 7vot:k, 7vot:o, 7vot:q, 7vot:s, 7vot:u, 7vot:w, 7vot:5, 7vot:b1, 7vot:6, 7voy:A, 7voy:D, 7voy:F, 7voy:I, 7voy:K, 7voy:O, 7voy:Q, 7voy:S, 7voy:U, 7voy:W, 7voy:Y, 7voy:1, 7voy:7, 7voy:9, 7voy:4, 7voy:6, 7voy:C, 7vy2:A, 7vy2:D, 7vy2:F, 7vy2:I, 7vy2:K, 7vy2:O, 7vy2:Q, 7vy2:S, 7vy2:V, 7vy2:Y, 7vy2:1, 7vy2:3, 7vy2:5, 7vy2:7, 7vy2:a, 7vy2:d, 7vy2:f, 7vy2:i, 7vy2:k, 7vy2:o, 7vy2:q, 7vy2:s, 7vy2:v, 7vy2:y, 7vy2:01, 7vy2:03, 7vy2:05, 7vy2:07, 7vy3:Y, 7vy3:A, 7vy3:D, 7vy3:F, 7vy3:I, 7vy3:K, 7vy3:O, 7vy3:Q, 7vy3:S, 7vy3:V
11 7o0u:ak 71 20 0.2973 0.1549 0.5500 0.098 7o0u:ah, 7o0u:ac, 7o0u:af, 7o0u:aa, 7o0u:ab, 7o0u:ad, 7o0u:ae, 7o0u:ag, 7o0u:ai, 7o0u:aj, 7o0u:al, 7o0u:am, 7o0u:an, 7o0u:ao, 7o0u:ap, 7o0v:af, 7o0v:ah, 7o0v:ac, 7o0v:ae, 7o0v:aa, 7o0v:ab, 7o0v:ad, 7o0v:ag, 7o0v:ai, 7o0v:aj, 7o0v:ak, 7o0v:al, 7o0v:am, 7o0v:an, 7o0v:ao, 7o0v:ap, 7o0w:ac, 7o0w:af, 7o0w:aa, 7o0w:ab, 7o0w:ad, 7o0w:ae, 7o0w:ag, 7o0w:ah, 7o0w:ai, 7o0w:aj, 7o0w:ak, 7o0w:al, 7o0w:am, 7o0w:an, 7o0w:ao, 7o0w:ap, 7o0x:ah, 7o0x:ac, 7o0x:af, 7o0x:aa, 7o0x:ab, 7o0x:ad, 7o0x:ae, 7o0x:ag, 7o0x:ai, 7o0x:aj, 7o0x:ak, 7o0x:al, 7o0x:am, 7o0x:ao, 7o0x:an, 7o0x:ap
12 7ddq:o 53 34 0.3243 0.2264 0.3529 0.13 7ddq:n, 7ddq:t, 7ddq:s, 7ddq:u, 7ddq:r, 7ddq:a, 7ddq:b, 7ddq:e, 7ddq:d, 7ddq:k, 7ddq:j, 7ddq:f, 7ddq:i, 7ddq:g
13 8wdv:Y 64 20 0.2703 0.1562 0.5000 0.14 7vrj:S, 7vrj:U, 8wdu:U, 8wdu:W, 8wdu:D, 8wdu:F, 8wdu:S, 8wdu:Y, 8wdv:W, 8wdv:D, 8wdv:F, 8wdv:S, 8wdv:U
14 6et5:3 58 18 0.2973 0.1897 0.6111 0.38 6et5:P, 6et5:S, 6et5:V, 6et5:Y, 6et5:b, 6et5:e, 6et5:h, 6et5:k, 6et5:n, 6et5:q, 6et5:t, 6et5:w, 6et5:z, 6et5:6, 6et5:F, 6et5:K
15 7vrj:Y 63 20 0.2432 0.1429 0.4500 0.38 7vrj:D, 7vrj:F, 7vrj:W
16 4d1a:A 456 19 0.2703 0.0219 0.5263 2.4 4d1b:A, 4d1c:A, 4d1d:A
17 5b5m:A 60 20 0.2973 0.1833 0.5500 3.3 5b5m:9, 5b5m:D, 5b5m:F, 5b5m:I, 5b5m:K, 5b5m:O, 5b5m:Q, 5b5m:S, 5b5m:U, 5b5m:W, 5b5m:Y, 5b5m:1, 5b5m:3, 5b5m:5, 5b5m:7, 5b5m:AA, 5b5m:m, 5b5m:l, 5b5m:p, 5b5m:r, 5b5m:u, 5b5m:w, 5b5m:AC, 5b5m:AE, 5b5m:AG, 5b5m:AI, 5b5m:AK, 5b5m:d, 5b5m:f, 5b5m:h, 5b5m:j, 5b5n:A, 5b5n:9, 5b5n:D, 5b5n:F, 5b5n:I, 5b5n:K, 5b5n:O, 5b5n:Q, 5b5n:S, 5b5n:U, 5b5n:W, 5b5n:Y, 5b5n:1, 5b5n:3, 5b5n:5, 5b5n:7, 5b5n:AA, 5b5n:m, 5b5n:j, 5b5n:l, 5b5n:p, 5b5n:r, 5b5n:u, 5b5n:w, 5b5n:AC, 5b5n:AE, 5b5n:AG, 5b5n:AI, 5b5n:AK, 5b5n:d, 5b5n:f, 5b5n:h, 7c52:7, 7c52:S, 7c52:A, 7c52:D, 7c52:F, 7c52:9, 7c52:I, 7c52:K, 7c52:O, 7c52:Q, 7c52:U, 7c52:W, 7c52:Y, 7c52:1, 7c52:3, 7c52:5, 4v8k:AA, 4v8k:AD, 4v8k:A9, 4v8k:AF, 4v8k:AI, 4v8k:AK, 4v8k:AO, 4v8k:AQ, 4v8k:AS, 4v8k:AW, 4v8k:AU, 4v8k:AY, 4v8k:A1, 4v8k:A3, 4v8k:A5, 4v8k:A7, 4v8k:BA, 4v8k:BD, 4v8k:B9, 4v8k:BF, 4v8k:BI, 4v8k:BK, 4v8k:BO, 4v8k:BQ, 4v8k:BS, 4v8k:BU, 4v8k:BW, 4v8k:BY, 4v8k:B1, 4v8k:B3, 4v8k:B5, 4v8k:B7, 3wmm:A, 3wmm:7, 3wmm:9, 3wmm:D, 3wmm:F, 3wmm:I, 3wmm:K, 3wmm:O, 3wmm:Q, 3wmm:S, 3wmm:U, 3wmm:W, 3wmm:Y, 3wmm:1, 3wmm:3, 3wmm:5, 5y5s:7, 5y5s:S, 5y5s:A, 5y5s:D, 5y5s:F, 5y5s:I, 5y5s:K, 5y5s:O, 5y5s:Q, 5y5s:U, 5y5s:W, 5y5s:Y, 5y5s:1, 5y5s:3, 5y5s:5, 5y5s:9
18 6et5:1 55 27 0.2703 0.1818 0.3704 5.4 6et5:4, 6et5:G, 6et5:N, 6et5:Q, 6et5:T, 6et5:W, 6et5:Z, 6et5:c, 6et5:f, 6et5:i, 6et5:l, 6et5:o, 6et5:r, 6et5:u, 6et5:x, 6et5:7

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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