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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
RLPFSFANRFKMVLEVPPVLYYVEPLNAQALVEVRRVLKQTFVPQAIAAEAFEKKLTEAYDFFSLAEEAPIIKLINAMLG
EAIKEGASDIHIETFEKILSIRFRVDGVLRDVLSPSRKLAPLLVSRVKVMAKLDIAEKRVPQDGRISLAVDVRVSTMPSS
HGERVVMRLLDKNATRLDLHSLGMTPVNHDNFRHLISRPHGIILVTGPTGSGKSTTLYAGLQELNSNERNILTVEDPIEF
DIDGIGQTQVNPKVDMTFARGLRAILRQDPDVVMVGEIRDLETAQIAVQASLTGHLVMSTLHTNTAVGAITRLRDMGIEP
FLISSSLLGVLAQRLVRTLCQDCKEPYEADKEQRKLFALTLYRAKGCEKCNHKGYRGRTGIHELLMVDDKVQELIHAEAG
EQAMDKYIREHTPSIRSDGLDKVLQGVTSLEEVMRVTK

The query sequence (length=438) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4pht:B 442 441 1.0000 0.9910 0.9932 0.0 1p9r:A, 1p9w:A, 4pht:A, 4pht:C
2 5tsh:E 387 383 0.4110 0.4651 0.4700 1.35e-124 5tsg:B, 5tsg:C, 5tsg:D, 5tsh:A, 5tsh:B, 5tsh:C, 5tsh:D, 5tsh:F, 5zfr:A, 5zfr:B, 5zfr:C
3 5oiu:C 386 383 0.4224 0.4793 0.4830 1.96e-122 5it5:F, 5it5:A, 5it5:B, 5it5:E, 5it5:C, 5it5:D, 5oiu:A, 5oiu:B, 5oiu:D, 5oiu:E, 5oiu:F
4 8dzg:A 420 404 0.2740 0.2857 0.2970 5.90e-37 8dze:A, 8dze:B, 8dze:C, 8dze:D, 8dze:E, 8dze:F, 8dzf:A, 8dzf:B, 8dzf:C, 8dzf:D, 8dzf:E, 8dzf:F, 8dzg:B, 8dzg:C, 8dzg:D, 8dzg:E, 8dzg:F
5 3jvv:C 337 286 0.2329 0.3027 0.3566 1.22e-35 3jvv:A, 3jvv:B
6 2ewv:A 343 277 0.2192 0.2799 0.3466 3.02e-32 2eww:A, 2gsz:F
7 6ojz:D 361 256 0.2055 0.2493 0.3516 3.38e-31 6ojx:A, 6ojx:B, 6ojx:C, 6ojz:A, 6ojz:B, 6ojz:C, 6ojz:E, 6ojz:F, 6ok2:A, 6ok2:B, 6ok2:C, 6ok2:D, 6ok2:E, 6ok2:F, 6okv:A, 6okv:B, 6okv:C, 6okv:D, 6okv:E, 6okv:F, 6olm:A, 6olm:B, 6olm:C, 6olm:D, 6olm:E, 6olm:F
8 5fl3:A 354 155 0.1712 0.2119 0.4839 3.72e-31
9 2oap:2 503 209 0.1416 0.1233 0.2967 1.70e-11 2oap:1, 2oaq:2
10 4ihq:A 512 152 0.1187 0.1016 0.3421 8.03e-10 4ihq:B, 4ihq:C
11 6bge:A 323 116 0.0845 0.1146 0.3190 1.28e-06 6bge:B, 1g6o:A, 1g6o:B, 1nly:A, 1nly:B
12 8rjf:A 424 122 0.0890 0.0920 0.3197 1.78e-05 8rjf:B, 8rjf:C, 8rjf:D, 8rjf:E, 8rjf:F, 8rkd:F, 8rkd:A, 8rkd:C, 8rkd:D
13 8xqw:A 988 60 0.0502 0.0223 0.3667 0.045
14 8ui7:A 643 28 0.0342 0.0233 0.5357 0.084 8ui8:A, 8ui9:A, 8uii:A
15 7oar:B 413 37 0.0342 0.0363 0.4054 0.087
16 7oar:A 442 37 0.0342 0.0339 0.4054 0.097 7bil:A, 7bil:B, 6s3h:A, 6s3h:B, 6s3i:A, 6s3m:A, 6s3m:B, 6s3n:A, 6s3n:B, 6s3o:A, 6s3p:A
17 8hpl:C 384 42 0.0502 0.0573 0.5238 0.16 7cag:C, 7cag:D, 8hpl:D, 8hpm:C, 8hpm:D, 8hpn:C, 8hpn:D, 8hpr:C, 8hpr:D, 8hps:C, 8hps:D
18 3pih:A 836 55 0.0502 0.0263 0.4000 0.46
19 6n9l:A 625 55 0.0502 0.0352 0.4000 0.52
20 7cte:D 406 109 0.0731 0.0788 0.2936 0.67 7ctf:D, 7ctg:D, 7jpo:D, 7jpp:D, 7jpq:D, 7jpr:D, 7jps:D, 5uj7:C, 5uj7:D, 5ujm:D
21 8swn:A 1135 34 0.0342 0.0132 0.4412 0.92
22 6nje:A 297 46 0.0320 0.0471 0.3043 0.96
23 7mqa:NS 914 39 0.0388 0.0186 0.4359 1.1 6o16:A, 6o16:B
24 6tej:B 585 58 0.0479 0.0359 0.3621 1.5
25 8ptk:f 4502 38 0.0297 0.0029 0.3421 2.1 8ptk:e
26 7z8f:e 4579 38 0.0297 0.0028 0.3421 2.2 5owo:A, 8pr2:f, 8ptk:m, 8ptk:n, 7z8f:f, 7z8f:m, 7z8f:n, 7z8h:A
27 5nug:A 2920 38 0.0297 0.0045 0.3421 2.3 5nug:B
28 8pqw:A 2892 38 0.0297 0.0045 0.3421 2.4 8pqy:A, 8pqz:A, 8pqz:J
29 7z8g:A 3047 38 0.0297 0.0043 0.3421 2.6 8fdu:A, 7z8l:f
30 8dyu:A 2562 38 0.0297 0.0051 0.3421 2.6 8dyv:A
31 8fcy:A 2864 38 0.0297 0.0045 0.3421 2.7 8fd6:A, 8fdt:A
32 4ymu:J 240 66 0.0525 0.0958 0.3485 2.9 4ymu:A, 4ymv:J, 4ymv:A
33 4fxp:B 200 47 0.0365 0.0800 0.3404 3.2 4fxp:A, 4fxp:C, 3uie:A, 3uie:B, 3uie:C
34 3c41:J 242 66 0.0525 0.0950 0.3485 3.3 3c41:K, 3c4j:A, 3c4j:B, 2olj:A, 2olj:B, 2olk:A, 2olk:B, 2olk:C, 2olk:D, 2q0h:A, 2q0h:B
35 8c6j:V 934 81 0.0525 0.0246 0.2840 3.9 6hys:A, 6hys:B, 6hys:C, 6hys:D, 6hyt:A, 6hyt:B, 6hyt:C, 6hyt:D, 6hyu:A
36 8bjf:A 1195 27 0.0320 0.0117 0.5185 3.9 8bwp:A, 8bwq:A, 8bwr:A, 8sx7:A, 8sx8:A, 8sxb:A
37 8i4a:A 1218 27 0.0320 0.0115 0.5185 4.1 8bwo:A, 8i4c:A, 8j3w:A, 8j3z:A, 8xol:A, 8xom:A
38 7pnv:b 323 40 0.0411 0.0557 0.4500 4.1
39 8a8h:B 146 17 0.0251 0.0753 0.6471 4.2
40 8iza:A 1246 27 0.0320 0.0112 0.5185 4.2 8iz7:A, 8iz9:A, 8xok:A
41 6zyw:C 4433 18 0.0297 0.0029 0.7222 4.4
42 8bx8:A 4453 18 0.0297 0.0029 0.7222 4.4 7k58:A, 7k5b:A, 7kek:A
43 8bwy:C 4264 18 0.0297 0.0030 0.7222 4.4
44 8r9r:A 255 28 0.0297 0.0510 0.4643 4.5
45 7moq:C 4159 18 0.0297 0.0031 0.7222 4.7 6zyy:C
46 8a22:Bw 349 54 0.0365 0.0458 0.2963 4.8 8apn:Bw, 8apo:Bw
47 7yzp:C 448 21 0.0251 0.0246 0.5238 5.4 7yzp:D
48 6ks6:d 524 68 0.0525 0.0439 0.3382 5.5 6ks6:D, 4v81:D, 4v81:L, 4v81:l, 4v8r:AD, 4v8r:Ad, 4v8r:BD, 4v8r:Bd, 4v94:D, 4v94:L, 4v94:d, 4v94:l, 7ylw:D, 7ylw:d, 7ylx:D, 7ylx:d, 7yly:D, 7yly:d
49 7ln6:F 714 136 0.0799 0.0490 0.2574 5.6 3cf0:A, 3cf0:B, 3cf0:C, 3cf0:D, 3cf0:E, 3cf0:F, 3cf0:G, 3cf0:H, 3cf0:I, 3cf0:J, 3cf0:K, 3cf0:L, 3cf0:M, 3cf0:N, 6g2v:A, 6g2w:A, 6g2x:A, 6g2y:A, 6g2z:A, 6g30:A, 7lmz:F, 7ln0:F, 7ln1:F, 7ln2:F, 7ln3:F, 7ln4:F, 7ln5:F, 6mck:A, 6mck:B, 6mck:C, 6mck:D, 6mck:E, 6mck:F, 6mck:G, 6mck:H, 6mck:I, 6mck:J, 6mck:K, 6mck:L, 8vku:A, 8vku:B, 8vku:C, 8vku:D, 8vku:E, 8vku:F, 8vls:A, 8vls:B, 8vls:C, 8vls:D, 8vls:E, 8vls:F, 8vls:G, 8vls:H, 8vls:I, 8vls:J, 8vls:K, 8vls:L, 8vov:A, 8vov:B, 8vov:C, 8vov:D, 8vov:E, 8vov:F
50 5txv:X 360 71 0.0548 0.0667 0.3380 6.1 1g4a:E, 1g4a:F, 5ji2:F, 5ji3:F, 5txv:F, 5txv:I, 5txv:M, 5txv:O, 5txv:R, 5txv:V, 5txv:W
51 6s85:D 375 21 0.0251 0.0293 0.5238 6.2 6s6v:C, 6s6v:D, 6s85:C, 7yzo:C, 7yzo:D, 7z03:D, 7z03:C
52 7z6h:K 439 17 0.0251 0.0251 0.6471 6.4
53 6d3r:A 1127 97 0.0685 0.0266 0.3093 6.7 6d3s:A
54 5jpq:q 169 43 0.0388 0.1006 0.3953 7.6 4v7r:AD, 4v7r:CD
55 6erp:A 1011 86 0.0502 0.0218 0.2558 7.6 6erp:B, 6erq:A, 6erq:B
56 3spa:A 941 86 0.0502 0.0234 0.2558 7.9 7a8p:A
57 5mrc:B 321 159 0.0868 0.1184 0.2390 8.5 3j6b:B, 5mre:B, 5mrf:B
58 8ipr:A 504 42 0.0388 0.0337 0.4048 8.8 8ipr:D
59 8po7:A 594 20 0.0251 0.0185 0.5500 8.9
60 6zww:C 749 20 0.0251 0.0147 0.5500 9.0 8po7:B, 8po8:A, 8po8:B, 6zww:A, 6zww:E, 6zww:G
61 9bdc:E 990 86 0.0502 0.0222 0.2558 9.1 9bdd:E, 4boc:A, 5ola:E, 5ola:F, 8u8u:E, 8u8v:E
62 1w1d:A 143 22 0.0251 0.0769 0.5000 9.2 1w1g:A
63 7tfk:A 360 71 0.0434 0.0528 0.2676 10.0 7tfl:A
64 6msg:F 395 74 0.0457 0.0506 0.2703 10.0 8cvt:F, 5gjq:M, 5gjr:M, 5gjr:0, 6msb:F, 6msh:F, 6msk:F, 7qxn:F, 7qxp:F, 7qxu:F, 7qxx:F, 7qya:F, 7qyb:F, 5vfp:F, 5vfq:F, 5vfr:F, 5vfs:F, 7w37:F, 7w3b:F, 7w3c:F, 7w3g:F, 7w3h:F, 7w3m:F, 6wjn:F

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218