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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
QKIAKTFTVDVSSPTENGVFDPASYAKYLIDHIKVEGAVGNLGNAVTVTEDGTVVTVVSTAKFSGKYLKYLTKKYLKKNQ
LRDWIRFVSTKTNEYRLAFYQVTP

The query sequence (length=104) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8hfr:UF 115 104 1.0000 0.9043 1.0000 3.80e-73 8aaf:H, 8agt:H, 8agu:H, 8agv:H, 8agw:H, 8agx:H, 8agz:H, 5apn:U, 5apo:U, 7azy:w, 7b7d:Lq, 8bip:LU, 8bjq:LU, 8bn3:N2, 8bqd:BL, 8bqx:BL, 7bt6:U, 7btb:U, 8ccs:G, 8cdl:G, 8cdr:G, 8ceh:G, 8cf5:G, 8cg8:G, 8cgn:G, 8civ:G, 8cku:G, 8cmj:G, 5dat:N2, 5dat:n2, 5dc3:N2, 5dc3:n2, 5dge:N2, 5dge:n2, 5dgf:N2, 5dgf:n2, 5dgv:N2, 5dgv:n2, 6elz:U, 6em5:U, 8eub:AU, 8evp:AU, 8evq:AU, 8evr:AU, 8evs:AU, 8evt:AU, 8ewb:AU, 8ewc:AU, 5fci:N2, 5fci:n2, 5fcj:N2, 5fcj:n2, 6ft6:U, 5gak:W, 6gq1:U, 6gqb:U, 6gqv:U, 5h4p:U, 6hd7:W, 6hhq:5, 6hhq:CW, 5i4l:N2, 5i4l:n2, 6i7o:BL, 6i7o:YL, 5it7:UU, 3j6x:62, 3j6y:62, 3j77:72, 3j78:72, 3jct:U, 5juo:Z, 5jup:Z, 5jus:Z, 5jut:Z, 5juu:Z, 8k2d:LU, 8k82:LU, 5lyb:N2, 5lyb:n2, 5m1j:U5, 6m62:U, 5mc6:BL, 5mei:5, 5mei:CW, 7mpi:AU, 7mpj:AU, 6n8j:U, 6n8k:U, 6n8l:U, 6n8m:h, 6n8n:h, 6n8o:h, 7n8b:AU, 7nac:U, 7nad:U, 5ndg:N2, 5ndg:n2, 5ndv:N2, 5ndv:n2, 5ndw:N2, 5ndw:n2, 7nrc:LW, 7nrd:LW, 5obm:N2, 5obm:n2, 7of1:U, 7oh3:U, 7ohq:U, 7ohr:U, 7ohv:U, 6oig:U, 5on6:5, 5on6:CW, 7osa:eL22, 7osm:eL22, 8p8m:QU, 8p8n:QU, 8p8u:QU, 8pfr:QU, 6q8y:BL, 6qik:V, 6qt0:V, 6qtz:V, 7r72:U, 7r7a:U, 6r84:W, 6r86:W, 6r87:W, 6ri5:V, 7rr5:LU, 6rzz:V, 6s05:V, 6s47:AW, 6snt:au, 6sv4:BL, 6sv4:YL, 6sv4:ZL, 6t4q:LU, 5t62:h, 5t6r:h, 6t7i:LU, 6t7t:LU, 6t83:Uy, 6t83:F, 5tbw:5, 5tbw:CW, 6tb3:BL, 5tga:N2, 5tga:n2, 5tgm:N2, 5tgm:n2, 6tnu:BL, 7too:AL22, 7top:AL22, 7u0h:U, 4u3m:N2, 4u3m:n2, 4u3n:N2, 4u3n:n2, 4u3u:N2, 4u3u:n2, 4u4n:N2, 4u4n:n2, 4u4o:N2, 4u4o:n2, 4u4q:N2, 4u4q:n2, 4u4r:N2, 4u4r:n2, 4u4u:N2, 4u4u:n2, 4u4y:N2, 4u4y:n2, 4u4z:N2, 4u4z:n2, 4u50:N2, 4u50:n2, 4u51:N2, 4u51:n2, 4u52:N2, 4u52:n2, 4u53:N2, 4u53:n2, 4u55:N2, 4u55:n2, 4u56:N2, 4u56:n2, 4u6f:N2, 4u6f:n2, 7ug6:U, 7uoo:U, 7uqb:U, 7uqz:U, 6uz7:AU, 7v08:U, 4v6i:BW, 4v88:BU, 4v88:DU, 4v8t:U, 4v8y:BU, 4v8z:BU, 8v87:U, 4v91:U, 6woo:U, 6xiq:U, 6xir:U, 8y0u:LU, 6ylg:U, 6ylh:U, 6ylx:U, 6yly:U, 7z34:U, 6z6j:LU, 6z6k:LU, 7zpq:BT, 7zrs:BT, 7zs5:BV, 7zuw:BT, 7zux:ET, 7zw0:LX
2 8esq:U 98 95 0.4519 0.4796 0.4947 2.56e-30 8esr:U, 8etc:U, 8etg:U, 8eug:U, 8eui:U
3 7r81:W1 101 101 0.4615 0.4752 0.4752 3.33e-30
4 8i9x:LU 105 103 0.4327 0.4286 0.4369 8.23e-29 8i9y:LU, 8i9z:LU, 8ia0:LU, 7olc:LU, 7old:LU, 8oo0:LU, 8pv1:LU, 8pv2:LU, 8pv3:LU, 8pv4:LU, 8pv5:LU, 8pv6:LU, 8pv7:LU, 8pv8:LU, 8pvk:LU, 8pvl:LU, 7z3n:LU, 7z3o:LU
5 8c3a:5 103 102 0.6058 0.6117 0.6176 2.82e-28 8c3a:BP, 8cq7:5, 8cq7:BP, 8cqw:5, 8cqw:BP, 8cre:5, 8cre:BP, 8oeq:5, 8oeq:BP, 7pzy:5, 7q08:5, 7q0f:5, 7q0p:5, 7q0r:5, 8q5i:5
6 9bh5:CU 100 100 0.4038 0.4200 0.4200 9.72e-22 9cai:CU
7 8rxh:LU 122 99 0.3462 0.2951 0.3636 7.24e-20 8a3w:U, 8a98:U, 6az3:U, 3jcs:U, 8rxx:LU, 5t2a:T
8 8ova:BV 122 99 0.3365 0.2869 0.3535 6.01e-19 8ove:BV, 4v8m:BV
9 4v6x:CU 112 98 0.4423 0.4107 0.4694 1.25e-18 7a01:82, 8a3d:O, 5aj0:AU, 8b5l:U, 8b6c:U, 9bdl:AL22, 9bdn:AL22, 9bdp:AL22, 7bhp:LU, 8bhf:H1, 8bpo:T2, 8btk:BU, 7cpu:LU, 7cpv:LU, 4d5y:U, 4d67:U, 6d90:U, 6d9j:U, 9f1b:BU, 9f1c:BU, 9f1d:BU, 7f5s:LU, 8fkz:LF, 8fl2:LF, 8fl3:LF, 8fl4:LF, 8fl6:LF, 8fl7:LF, 8fl9:LF, 8fla:LF, 8flb:LF, 8flc:LF, 8fld:LF, 8fle:LF, 8flf:LF, 9fq0:LU, 6frk:U, 6ftg:U, 6fti:U, 6ftj:U, 8g5y:LU, 8g5z:LU, 8g60:LU, 8g61:LU, 8g6j:LU, 8glp:LU, 6gz3:AU, 6gz4:AU, 6gz5:AU, 6hcf:U3, 6hcj:U3, 6hcm:U3, 6hcq:U3, 8idt:d, 8idy:d, 8ie3:d, 8ifd:2O, 8ife:2O, 8ine:d, 8inf:d, 8ink:d, 6ip5:2O, 6ip6:2O, 6ip8:2O, 8ipd:d, 8ipx:d, 8ipy:d, 8ir1:d, 8ir3:d, 3j7o:U, 3j7p:U, 3j7q:U, 3j7r:U, 3j92:U, 3jag:U, 3jah:U, 3jai:U, 3jaj:U, 3jan:U, 8jdj:Z, 8jdk:Z, 8jdl:Z, 8jdm:Z, 8k2c:LU, 5lks:LU, 6lqm:d, 6lsr:d, 6lss:d, 7ls1:O2, 7ls2:O2, 6lu8:d, 5lzs:U, 5lzt:U, 5lzu:U, 5lzv:U, 5lzw:U, 5lzx:U, 5lzy:U, 5lzz:U, 7mdz:U, 6mtb:U, 6mtc:U, 6mtd:U, 6mte:U, 7nfx:U, 7nwg:U3, 7nwh:U, 7nwi:U, 7o7y:BU, 7o7z:BU, 7o80:BU, 7o81:BU, 7obr:U, 8ohd:LU, 8oj0:LU, 8oj5:LU, 8oj8:LU, 6ole:V, 6olf:V, 6olg:AU, 6oli:V, 6olz:AU, 6om0:V, 6om7:V, 7oya:U1, 7oyb:U1, 7oyc:U1, 7oyd:U, 8p2k:BU, 6p5i:AU, 6p5j:AU, 6p5k:AU, 6p5n:AU, 8q7z:BU, 8q87:BU, 8qfd:U, 7qgg:V, 8qoi:LU, 7qvp:LU, 7qvp:MU, 7qwq:U, 7qwr:U, 7qws:U, 6qzp:LU, 6r5q:U, 6r6g:U, 6r6p:U, 6r7q:U, 8rjb:U, 8rjc:U, 8rjd:U, 8scb:U, 6sgc:U2, 6swa:S, 5t2c:O, 6t59:U3, 7tm3:U, 7toq:AL22, 7tor:AL22, 7tut:U, 7ucj:U, 7uck:U, 4ug0:LU, 4ujc:BU, 4ujd:AU, 4uje:CU, 6w6l:V, 6xa1:LU, 7xnx:LU, 7xny:LU, 8xsx:LU, 8xsy:LU, 8xsz:LU, 6y0g:LU, 8y0w:LU, 8y0x:LU, 6y2l:LU, 6y57:LU, 6y6x:LU, 8yoo:LU, 8yop:LU, 6z6l:LU, 6z6m:LU, 6z6n:LU, 7zjw:LX, 7zjx:LX, 6zm7:LU, 6zme:LU, 6zmi:LU, 6zmo:LU, 6zvk:82
10 6xu6:CU 96 96 0.3269 0.3542 0.3542 1.41e-18 6xu7:CU
11 8p5d:LU0 100 95 0.3269 0.3400 0.3579 3.52e-17 8p60:LU0, 8p60:KU0, 7qca:LU0
12 7qiw:W 101 99 0.4231 0.4356 0.4444 1.50e-16 8azw:K, 8b2l:K3, 7qiz:W
13 4v3p:LW 108 100 0.4615 0.4444 0.4800 3.01e-16 8ip8:ZA, 8ipa:ZA, 8ipb:ZA, 8jiv:CU, 4v7e:CU
14 4v6w:CU 116 104 0.4327 0.3879 0.4327 3.24e-16 6xu8:CU
15 3j79:X 97 95 0.2885 0.3093 0.3158 3.38e-16 3jbn:AX, 3jbo:AX, 3jbp:AX, 8tpu:AX, 5umd:X
16 8ovj:U 107 100 0.3269 0.3178 0.3400 3.80e-14
17 5xxb:T 99 95 0.3846 0.4040 0.4211 6.28e-14
18 5t5h:V 85 96 0.3173 0.3882 0.3438 6.88e-14
19 5xy3:U 97 94 0.2692 0.2887 0.2979 1.04e-12
20 6zj3:Lj 101 98 0.4135 0.4257 0.4388 1.80e-12
21 4v8p:AM 100 99 0.4038 0.4200 0.4242 1.90e-12 4v8p:DM, 4v8p:FM, 4v8p:HM
22 6zu5:LU0 97 96 0.2981 0.3196 0.3229 6.65e-07
23 8bf9:U 84 94 0.3750 0.4643 0.4149 8.55e-04
24 8btd:LV 115 97 0.2404 0.2174 0.2577 0.004 8br8:LV, 8brm:LV, 8bsi:LV, 8bsj:LV, 8btr:LV, 8fru:U, 7pwg:U, 7pwo:U2
25 2d3l:A 481 91 0.2596 0.0561 0.2967 0.89 2d3n:A, 1wp6:A, 1wpc:A
26 4kbl:A 395 68 0.1538 0.0405 0.2353 1.1 4kbl:B, 5udh:B
27 7b5l:H 423 68 0.1538 0.0378 0.2353 1.2 7b5n:H, 4kc9:A, 5udh:A
28 5tte:B 442 68 0.1538 0.0362 0.2353 1.2 7b5m:H, 2m9y:A, 1wd2:A
29 4v58:G 2060 61 0.1731 0.0087 0.2951 1.5 4v58:H, 4v58:I, 4v58:J, 4v58:K, 4v58:L, 4v59:G, 4v59:H, 4v59:I, 4v59:J, 4v59:K, 4v59:L
30 1be3:A 446 58 0.1635 0.0381 0.2931 1.6 2a06:A, 1bgy:A, 1bgy:M, 4d6t:N, 4d6u:A, 4d6u:N, 7dgq:k, 7dgq:w, 7dgr:k, 7dgr:w, 7dgs:k, 7dgs:w, 7dkf:A1, 7dkf:M1, 6fo0:N, 6fo0:A, 6fo2:N, 6fo2:A, 5luf:c, 5luf:l, 5nmi:N, 5nmi:A, 1pp9:A, 1ppj:A, 6qbx:a3, 6qc3:a1, 7tz6:A, 7tz6:N, 2ybb:a, 2ybb:A
31 6ag0:C 483 96 0.2500 0.0538 0.2708 1.6 6ag0:A, 1hvx:A, 4uzu:A
32 8sr8:A 1353 38 0.1250 0.0096 0.3421 2.4 8sr8:B, 8sr8:C, 8sr8:D, 8sr9:A, 8sr9:B, 8sr9:C, 8sr9:D, 8sra:A, 8sra:B, 8sra:C, 8sra:D, 8srb:A, 8srb:B, 8srb:C, 8srb:D
33 8sre:A 1377 38 0.1250 0.0094 0.3421 2.5 8sr7:A, 8sr7:B, 8sr7:C, 8sr7:D, 8src:A, 8src:B, 8src:C, 8src:D, 8srd:A, 8srd:B, 8srd:C, 8srd:D, 8sre:B, 8sre:D, 8sre:C, 8srf:A, 8srf:B, 8srf:C, 8srf:D, 8srg:A, 8srg:B, 8srg:C, 8srg:D, 8srh:A, 8srh:B, 8srh:C, 8srh:D, 8sri:A, 8sri:B, 8sri:C, 8sri:D, 8srj:A, 8srj:B, 8srj:D, 8srj:C, 8srk:A, 8srk:B, 8srk:C, 8srk:D
34 6q0m:B 94 36 0.1250 0.1383 0.3611 3.9
35 2xiq:A 714 36 0.1250 0.0182 0.3611 4.1 8dyj:B, 8dyl:B, 2xij:A, 2xiq:B
36 8gju:J 689 36 0.1250 0.0189 0.3611 4.2 8gju:K, 8gju:L, 8gju:H
37 6sul:A 334 36 0.1058 0.0329 0.3056 4.7 6sul:B, 6sul:C, 6sul:D, 6sv5:A
38 8br8:SR 101 25 0.0962 0.0990 0.4000 5.3
39 2bmu:B 226 50 0.1442 0.0664 0.3000 6.1 2bmu:A, 2bri:A, 2bri:B, 2ji5:A, 2ji5:B
40 6oxd:A 736 27 0.1154 0.0163 0.4444 7.0 6oxc:A
41 7squ:A 542 32 0.0962 0.0185 0.3125 9.9 7squ:D, 7squ:G, 7squ:J, 7sqv:A
42 6sum:A 335 33 0.0962 0.0299 0.3030 9.9 6sum:B, 6sun:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218