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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
QISMRLYSNRDRPNHLGPLALERLARVDDVVAQPARQPEDGFAASEDSLLGDVEEYARLFTRFLDGPVAPLGDAIPDDPA
RRAENLKASAYFLDASMVGICRLDPGDCDPSHTHALVFAVQFGREPEAGEAGAEWIRGTNAARTDMRCAEIAAILSGYVR
WMGFPARGHFSGDAQVDLARLAVRAGLARVVDGVLVAPFLRRGFRLGVVTTGYALAADRPLAPEGDLGETAPEVMLGIDG
TRPGWEDAEEEKRPLHMGRYPMETIRRVDEPTTLVVRQEIQRVAKRGDFFKRAEAGDLGEKAKQEKKRFPMKHPLALGMQ
PLIQNMVPLQGTREKLAPTGKGGDLSDPGRNAEAIKALGYYLGADFVGICRAEPWMYYASDEVEGKPIEAYHDYAVVMLI
DQGYETMEGASGDDWISASQSMRAYMRGAEIAGVMAAHCRRMGYSARSHSNAHSEVIHNPAILMAGLGEVSRIGDTLLNP
FIGPRSKSIVFTTDLPMSVDRPIDFGLQDFCNQCRKCARECPCNAISFGDKVMFNGYEIWKADVEKCTKYRVTQMKGSAC
GRCMKMCPWNREDTVEGRRLAELSIKVPEARAAIIAMDDALQNGKRNLIKRWWFDLEVIDGVAGAPRMGTNERDLSPDRG
DKIGANQKLAMYPPRLQPPPGTTLDAVLPVDRSGGLAEYAAAETPAAARARLKSS

The query sequence (length=695) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 6zxu:A 701 699 1.0000 0.9914 0.9943 0.0 4ras:A, 4ras:B, 4ras:C, 6zxu:B, 6zxu:C, 6zxx:A, 6zxx:B, 6zxx:C, 6zy0:A, 6zy0:B, 6zy0:C, 6zy1:A, 6zy1:B, 6zy1:C
2 8q4h:A 503 282 0.1137 0.1571 0.2801 2.89e-22 8q4h:B
3 4ur3:A 458 309 0.1237 0.1878 0.2783 4.73e-22 5m2g:A, 5m2g:B, 5m8u:A, 5m8u:B, 5m8w:A, 5m8w:B, 5m8x:A, 5m8x:B, 5m8y:A, 5m8y:B, 5m8z:A, 5m8z:B, 5m90:A, 5m90:B, 5m91:A, 5m91:B, 5m92:A, 5m92:B, 5ma0:A, 5ma0:B, 5ma1:A, 5ma1:B, 5ma2:A, 5ma2:B, 5maa:A, 5maa:B, 5obi:A, 5obi:B, 5obp:A, 5obp:B, 4uqu:A, 4uqu:B, 4ur0:A, 4ur0:B, 4ur1:A, 4ur1:B, 4ur2:A, 4ur2:B, 4ur3:B, 4ur3:C, 4ur3:D, 4ur3:E, 4ur3:F
4 1clf:A 55 64 0.0317 0.4000 0.3438 4.39e-05
5 6h4n:y 351 72 0.0331 0.0655 0.3194 8.31e-04 8a3l:Y, 6h58:y, 6h58:yy
6 2zvs:A 81 58 0.0288 0.2469 0.3448 0.009 2zvs:B, 2zvs:C
7 7q4v:B 599 68 0.0331 0.0384 0.3382 0.011 8a5e:B, 7q4v:F, 7q4w:B, 7q4w:F
8 7z0s:F 164 91 0.0317 0.1341 0.2418 0.019 7z0t:F
9 4lox:A 300 57 0.0216 0.0500 0.2632 0.052 5e5o:A, 5e5s:A, 5e63:A, 5e67:A, 4z1z:A, 4z1z:B, 4z20:A, 4z20:D
10 1dur:A 55 62 0.0259 0.3273 0.2903 0.072
11 5d6s:A 370 95 0.0360 0.0676 0.2632 0.091 5d6s:B, 5d6s:C, 5d6s:D, 5d6s:E
12 5d08:A 384 121 0.0388 0.0703 0.2231 0.098 5d08:B, 5d0a:A, 5d0a:B, 5d0a:C, 5d0a:D, 5d0b:A, 5d0b:B, 5t8y:B, 5t8y:A
13 7p8n:B 613 62 0.0317 0.0359 0.3548 0.11 7p5h:B, 7p5h:E, 7p5h:b, 7p5h:e, 7p8n:b, 7p91:b, 7p91:B, 7p92:B
14 6fah:E 393 62 0.0245 0.0433 0.2742 0.19 6fah:A
15 7zc6:B 202 58 0.0273 0.0941 0.3276 0.28
16 7zc6:B 202 41 0.0216 0.0743 0.3659 7.4
17 7bkb:L 79 60 0.0216 0.1899 0.2500 0.33 7bkb:l, 7bkc:L, 7bkc:l
18 7plm:A 1177 64 0.0288 0.0170 0.3125 0.46 7plm:B
19 7bkd:A 664 62 0.0273 0.0286 0.3065 0.49 7bkb:A, 7bkb:a, 7bkc:A, 7bkc:a, 7bkd:a, 7bke:A, 7bke:a
20 3eun:A 81 62 0.0273 0.2346 0.3065 0.50 1blu:A, 3exy:A
21 6h8k:I 137 58 0.0230 0.1168 0.2759 0.54
22 7bkc:K 321 63 0.0302 0.0654 0.3333 0.86 7bkc:k
23 6uk5:A 240 39 0.0230 0.0667 0.4103 1.0 6uk5:B
24 7b0n:I 191 109 0.0345 0.1257 0.2202 1.0 6gcs:I, 7o6y:I, 7o71:I, 6rfq:I, 6rfr:I, 6rfs:I, 6y79:I, 6yj4:I
25 8e73:S8 181 61 0.0230 0.0884 0.2623 1.1 7a23:D, 7a24:D, 7aqr:I, 7ar7:I, 7ar8:I, 7arb:I, 8bee:I, 8bpx:I, 8bq5:I, 8bq6:I, 6x89:S8
26 1rgv:A 80 43 0.0216 0.1875 0.3488 1.5
27 7qv7:D 448 60 0.0273 0.0424 0.3167 1.7 7qv7:K, 7qv7:Q, 7qv7:R, 7qv7:V, 7qv7:Z
28 7bkb:K 386 63 0.0302 0.0544 0.3333 1.7 7bkb:k, 7bkc:M, 7bkc:m
29 1b0p:A 1231 69 0.0302 0.0171 0.3043 1.8 1b0p:B, 2c3m:A, 2c3m:B, 2c3o:A, 2c3o:B, 2c3p:A, 2c3p:B, 2c3u:A, 2c3u:B, 2c3y:A, 2c3y:B, 2c42:A, 2c42:B, 1kek:A, 1kek:B, 2pda:A, 2pda:B, 2uza:A, 2uza:B
30 8b6f:AL 218 61 0.0216 0.0688 0.2459 2.0 8bqs:AL, 8gym:s8, 8gym:S8, 8gzu:s8, 8gzu:S8, 7tgh:S8
31 7npa:A 618 69 0.0259 0.0291 0.2609 2.2 7npa:B, 7npa:C, 7npa:D, 7npa:E, 7npa:F, 7npa:G, 7npa:H, 7npa:I, 7npa:J, 7npa:K, 7npa:L, 7npa:M, 7npa:N, 7npa:O, 7npa:P
32 7arc:I 199 58 0.0245 0.0854 0.2931 2.3 7ard:I
33 7qv7:B 183 68 0.0245 0.0929 0.2500 2.4 7qv7:C, 7qv7:J, 7qv7:N, 7qv7:P, 7qv7:X
34 2fgo:A 81 66 0.0302 0.2593 0.3182 2.4
35 7wfg:I 160 36 0.0187 0.0813 0.3611 2.5 7wg5:I
36 8wm6:C 80 61 0.0245 0.2125 0.2787 2.8 8wmj:C, 8wmv:C, 8wmw:C, 7y5e:CN, 7y5e:C2, 7y7a:C7, 7y7a:Co, 7y7b:C, 7y8a:C
37 5t61:L 348 34 0.0201 0.0402 0.4118 3.2 5t5i:F, 5t5i:N, 5t5m:F, 5t61:F, 5t61:R, 5t61:X, 5t61:d, 5t61:j, 5t61:p, 5t61:v
38 7np8:B 620 61 0.0230 0.0258 0.2623 3.4 7np8:A, 7np8:C, 7np8:D
39 7zm7:I 185 61 0.0230 0.0865 0.2623 4.4 7zmb:I, 7zmg:I
40 7y1u:A 723 100 0.0374 0.0360 0.2600 6.5
41 6cfw:N 121 34 0.0129 0.0744 0.2647 7.5
42 5t5i:P 81 79 0.0317 0.2716 0.2785 8.5 5t5i:G, 5t5m:G, 5t61:E, 5t61:K, 5t61:Q, 5t61:W, 5t61:c, 5t61:i, 5t61:o, 5t61:u
43 8oh5:B 584 60 0.0245 0.0291 0.2833 8.7 8oh5:E, 8oh5:H, 8oh5:K, 8oh9:B, 8oh9:E, 8oh9:H, 8oh9:K
44 8qby:I 159 58 0.0230 0.1006 0.2759 8.8
45 7ak5:I 178 61 0.0230 0.0899 0.2623 9.3 7ak6:I, 7b93:I, 8c2s:I, 8ca3:I, 8ca5:I, 7dgq:E, 7dgr:E, 7dgs:E, 7dgz:E, 7dh0:E, 7dkf:E2, 6g2j:I, 6g72:I, 5gpn:b, 5gup:H, 8iao:I, 8iap:I, 8ib4:I, 8ib5:I, 8ib9:I, 8iba:I, 8ibd:I, 8ibe:I, 8ic2:I, 8ic3:I, 5lc5:I, 5ldw:I, 5ldx:I, 5lnk:9, 5o31:I, 8olt:I, 8om1:I, 7psa:I, 8pw5:9, 8pw6:9, 8pw7:9, 8q0a:I, 8q0f:I, 8q0j:I, 8q0m:I, 8q0o:I, 8q0q:I, 8q1p:I, 8q1u:I, 8q1y:I, 8q25:I, 8q45:I, 8q46:I, 8q47:I, 8q48:I, 8q49:I, 8q4a:I, 6q9d:S8, 6qa9:S8, 6qbx:S8, 6qc2:S8, 6qc3:S8, 6qc4:S8, 6qc5:S8, 6qc6:S8, 6qc7:S8, 6qc8:S8, 6qc9:S8, 6qca:S8, 6qcf:S8, 7qsd:I, 7qsk:I, 7qsl:I, 7qsm:I, 7qsn:I, 7qso:I, 7r41:I, 7r42:I, 7r43:I, 7r44:I, 7r45:I, 7r46:I, 7r47:I, 7r48:I, 7r4c:I, 7r4d:I, 7r4f:I, 7r4g:I, 8rgp:9, 8rgq:9, 8rgr:9, 8rgt:9, 8ud1:1I, 8ueo:1I, 8uep:1I, 8ueq:1I, 8uer:1I, 8ues:1I, 8uet:1I, 8ueu:1I, 8uev:1I, 8uew:1I, 8uex:1I, 8uey:1I, 8uez:1I, 8ugh:1I, 8ugi:1I, 8ugj:1I, 8ugn:1I, 8ugn:5I, 8ugp:1I, 8ugr:1I, 8ugr:5I, 7v2c:B, 7v2d:B, 7v2e:B, 7v2f:B, 7v2h:B, 7v2k:B, 7v2r:B, 7v30:B, 7v31:B, 7v32:B, 7v33:B, 7v3m:B, 7vb7:B, 7vbn:B, 7vbz:B, 7vwj:B, 7vxp:B, 7vxu:B, 7vy8:B, 7vya:B, 7vyf:B, 7vyh:B, 7vyn:B, 7vz1:B, 7vzv:B, 7vzw:B, 7w00:B, 7w0h:B, 7w0r:B, 7w0y:B, 7w1o:B, 7w1p:B, 7w1t:B, 7w1u:B, 7w1v:B, 7w1z:B, 7w20:B, 7w2k:B, 7w2l:B, 7w2r:B, 7w2u:B, 7w2y:B, 7w31:B, 7w32:B, 7w35:B, 7w4c:B, 7w4d:B, 7w4e:B, 7w4f:B, 7w4g:B, 7w4j:B, 7w4k:B, 7w4l:B, 7w4m:B, 7w4n:B, 7w4q:B, 5xtb:B, 5xtd:B, 5xth:B, 5xti:B, 5xti:BB, 7zd6:9, 7zdh:9, 7zdj:9, 7zdm:9, 7zdp:9, 7zeb:9, 6zk9:9, 6zkc:9, 6zkd:9, 6zke:9, 6zkf:9, 6zkg:9, 6zkh:9, 6zki:9, 6zkj:9, 6zkk:9, 6zkl:9, 6zkm:9, 6zkn:9, 6zko:9, 6zkp:9, 6zkq:9, 6zkr:9, 6zks:9, 6zkt:9, 6zku:9, 6zkv:9, 6zr2:I, 6ztq:I
46 8a8o:D 102 16 0.0129 0.0882 0.5625 9.3 8a8o:C

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218