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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
QEAKKVRITVDKDPVETSFEKWAKPGHFSRTLAKGPKTTTWIWNLHADAHDFDGHTSSLEDVSRKIFSAHFGQLSVIFLW
LSGMYFHGARFSNYVAWLSNPTAIKPSAQVVWPIVGQDILNGDVGGGFQGVQITSGFFQLWRASGITNEKQLYATAIGGL
VMSALMLFAGWFHYHKAAPKLEWFQNVESMMNHHLAGLLGLGCLSWAGHQIHVSLPINKLLDAGVAPSEIPLPHEFIVNR
ELMAQLYPSFSKGLTPFFTLDWNAYSDFLTFKGGLNPITGGLWLSDTAHHHLALAVLFIVAGHMYRTNWGIGHSMKEILE
AHKGPFTGEGHKGLYEILTTSWHAQLAINLAMIGSLSIIVAHHMYAMPPYPYIATDYPTQLSLFTHHMWIGGFCVTGAAA
HGAIFMVRDYSPAQNYNNLLDRMIRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMRALGRSQDMFSDTAIQLQPIFAQWI
QSIHTLAPGNTAPNALAATSYAFGGDIVAVNGKIAMMPIALGTADFMVHHIHAFTIHVTVLILLKGVLFARNSRLIPDKA
NLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSLSIVIFHFSWKMQSDVWGSVTPNGAVSHITGGNFAQSAITINGWL
RDFLWAQASQVIQSYGSALSAYGLIFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKLGPAIQPRALSITQGRAV
GLAHYLVGGIGTTWAFFLARIIAVG

The query sequence (length=745) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 7y5e:AN 745 745 1.0000 1.0000 1.0000 0.0 7y5e:A2, 7y7a:A7, 7y7a:Ao
2 8wm6:A 742 742 0.8913 0.8949 0.8949 0.0 8wmj:A, 8wmv:A, 8wmw:A, 7y7b:A, 7y8a:A
3 7blz:A 743 729 0.8698 0.8721 0.8889 0.0 6fos:A, 8wey:A, 5zgb:A, 5zgh:A
4 7dr0:A 739 739 0.8483 0.8552 0.8552 0.0 7dr1:A, 7dr2:aA, 7dr2:bA, 7dr2:cA, 7dr2:dA
5 6ly5:a 742 741 0.8604 0.8639 0.8650 0.0 6l4u:A
6 7yca:A 742 742 0.8617 0.8652 0.8652 0.0 7a4p:A, 7bgi:A, 7blx:A, 8cmo:A, 7d0j:A, 7dz7:A, 7dz8:A, 8h2u:A, 6ijj:A, 6ijo:A, 6jo5:A, 6jo6:A, 7r3k:A, 7wyi:A, 7wzn:A, 7zq9:A, 7zqc:A, 7zqd:A, 7zqd:A2, 6zzx:A, 6zzy:A
7 6tra:A 746 745 0.8577 0.8566 0.8577 0.0 4fe1:A, 7fix:A1, 7fix:A2, 7fix:A3, 1jb0:A, 6k33:aA, 6k33:bA, 6k33:cA, 6lu1:A, 7m75:A, 7m76:A, 7m78:A, 3pcq:A, 6pfy:A, 6pfy:G, 6pfy:Y, 6pgk:A, 6pgk:G, 6pgk:Y, 6trc:A, 6trc:a, 6trc:1, 6trd:A, 6trd:a, 6trd:1, 5zf0:A1, 5zf0:A2, 5zf0:A3, 5zf0:A4, 5zf0:A6, 5zf0:A5
8 6igz:A 740 741 0.8497 0.8554 0.8543 0.0 6qph:A, 6rhz:A, 6sl5:A, 6yxr:A
9 5l8r:A 743 742 0.8309 0.8331 0.8342 0.0 8bcv:A, 8bcw:A, 7dkz:A, 7ew6:A, 7ewk:A, 7f9o:A, 7f9o:e, 8htu:A, 8j6z:A, 8j7a:A, 8j7b:A, 7ksq:A, 7kux:A, 6l35:A, 3lw5:A, 2o01:A, 4rku:A, 7wfd:AA, 7wfe:BA, 7wg5:AA, 7wg5:BA, 8wgh:A, 2wsc:A, 2wse:A, 2wsf:A, 4xk8:A, 4xk8:a, 7xqp:A, 4y28:A, 6yac:A, 6yez:A, 5zji:A, 6zoo:A, 6zxs:A
10 5oy0:A 751 745 0.8403 0.8336 0.8403 0.0 8am5:a, 8asl:a, 8asp:a, 6hqb:A, 4kt0:A, 4l6v:A, 4l6v:a, 4l6v:1, 6nwa:A, 6nwa:a, 6nwa:H, 7o1v:A, 5oy0:a, 5oy0:1, 7umh:A, 7umh:H, 7umh:a, 6uzv:A, 6uzv:a, 6uzv:1, 6vpv:A, 6vpv:a, 6vpv:1
11 6k61:A 742 742 0.8201 0.8235 0.8235 0.0 6jeo:aA, 6jeo:bA, 6jeo:cA, 6jeo:dA, 6k61:a, 6tcl:A1, 6tcl:A2, 6tcl:A, 6tcl:AA, 7y3f:A
12 6kif:A 751 752 0.8322 0.8256 0.8245 0.0 6kif:G, 6kif:e, 6kig:A, 6kig:G, 6kig:e
13 7qco:A 728 728 0.8188 0.8379 0.8379 0.0 7qco:E, 7qco:e, 7qco:a
14 6kmw:aA 721 721 0.8027 0.8294 0.8294 0.0 6kmw:bA, 6kmw:cA
15 7s3d:A 749 745 0.7705 0.7664 0.7705 0.0 7s3d:G, 7s3d:a
16 7lx0:G 751 753 0.7745 0.7683 0.7663 0.0 7lx0:a, 7lx0:A, 6pnj:A, 6pnj:G, 6pnj:a
17 7dwq:A 726 723 0.7315 0.7507 0.7538 0.0
18 6kmx:aA 717 717 0.7195 0.7476 0.7476 0.0 6kmx:bA, 6kmx:cA
19 7coy:aA 685 713 0.7034 0.7650 0.7349 0.0 7coy:bA, 7coy:cA
20 7f4v:aA 772 774 0.7208 0.6956 0.6938 0.0 7f4v:bA, 7f4v:cA
21 8jjr:a 665 726 0.4846 0.5429 0.4972 0.0
22 8jze:a 670 727 0.4591 0.5104 0.4704 0.0 8jzf:a
23 8jw0:a 645 712 0.4752 0.5488 0.4972 0.0
24 7blz:B 731 751 0.4537 0.4624 0.4501 0.0 6fos:B, 8wey:B, 5zgb:B, 5zgh:B
25 7f4v:aB 725 747 0.4497 0.4621 0.4485 0.0 7f4v:bB, 7f4v:cB
26 6ly5:b 732 752 0.4456 0.4536 0.4415 0.0 6l4u:B
27 6kmw:aB 740 761 0.4523 0.4554 0.4428 0.0 6kmw:cB, 6kmw:bB
28 7d0j:B 734 753 0.4497 0.4564 0.4449 0.0 7a4p:B, 7bgi:B, 7blx:B, 8cmo:B, 7dz7:B, 7dz8:B, 8h2u:B, 6ijj:B, 6ijo:B, 6jo5:B, 6jo6:B, 6qph:B, 7r3k:B, 6rhz:B, 6sl5:B, 7wyi:B, 7wzn:B, 6yxr:B, 7zq9:B, 7zqc:B, 7zqd:B, 7zqd:B2, 6zzx:B, 6zzy:B
29 7y5e:BN 732 753 0.4456 0.4536 0.4409 0.0 7y5e:B2, 7y7a:B7, 7y7a:Bo, 7y7b:B, 7y8a:B
30 6vpv:B 737 757 0.4456 0.4505 0.4386 0.0 8am5:b, 8asl:b, 8asp:b, 6hqb:B, 4kt0:B, 4l6v:B, 4l6v:b, 4l6v:2, 6nwa:B, 6nwa:b, 6nwa:G, 7o1v:B, 5oy0:B, 5oy0:b, 5oy0:2, 7umh:B, 7umh:G, 7umh:b, 6uzv:B, 6uzv:b, 6uzv:2, 6vpv:b, 6vpv:2
31 6igz:B 733 753 0.4470 0.4543 0.4422 0.0
32 6kif:B 733 753 0.4430 0.4502 0.4382 0.0 6kif:H, 6kif:f, 6kig:B, 6kig:H, 6kig:f
33 8wm6:B 732 753 0.4416 0.4495 0.4369 0.0 8wmj:B, 8wmv:B, 8wmw:B
34 7s3d:B 742 762 0.4376 0.4394 0.4278 0.0 7s3d:H, 7s3d:b
35 7fix:B1 740 765 0.4497 0.4527 0.4379 0.0 7bw2:B, 4fe1:B, 7fix:B2, 7fix:B3, 1jb0:B, 6k33:aB, 6k33:bB, 6k33:cB, 7m75:B, 7m76:B, 7m78:B, 3pcq:B, 6pfy:H, 6pfy:B, 6pfy:Z, 6pgk:H, 6pgk:B, 6pgk:Z, 6tra:B, 6trc:B, 6trc:b, 6trc:2, 6trd:B, 6trd:b, 6trd:2, 5zf0:B1, 5zf0:B2, 5zf0:B3, 5zf0:B4, 5zf0:B6, 5zf0:B5
36 7yca:B 732 753 0.4376 0.4454 0.4329 0.0
37 7wfd:AB 734 753 0.4443 0.4510 0.4396 0.0 8bcv:B, 8bcw:B, 7dkz:B, 7ew6:B, 7ewk:B, 7f9o:B, 7f9o:f, 8htu:B, 8j6z:B, 8j7a:B, 8j7b:B, 7ksq:B, 7kux:B, 6l35:B, 5l8r:B, 3lw5:B, 2o01:B, 4rku:B, 7wfe:BB, 7wg5:AB, 7wg5:BB, 8wgh:B, 2wsc:B, 2wse:B, 2wsf:B, 4xk8:B, 4xk8:b, 7xqp:B, 4y28:B, 6yac:B, 6yez:B, 5zji:B, 6zoo:B, 6zxs:B
38 6kmx:aB 727 753 0.4349 0.4457 0.4303 0.0 6kmx:bB, 6kmx:cB
39 7qco:B 734 757 0.4282 0.4346 0.4214 0.0 7qco:G, 7qco:g, 7qco:b
40 7lx0:H 739 763 0.4242 0.4276 0.4142 0.0 7lx0:b, 7lx0:B, 6pnj:H, 6pnj:B, 6pnj:b
41 6lu1:B 713 758 0.4349 0.4544 0.4274 0.0
42 6k61:B 740 761 0.4309 0.4338 0.4218 0.0 6jeo:aB, 6jeo:bB, 6jeo:cB, 6jeo:dB, 6k61:b, 6tcl:B1, 6tcl:B2, 6tcl:B, 6tcl:BB, 7y3f:B
43 7dr0:B 706 760 0.4215 0.4448 0.4132 0.0 7dr1:B, 7dr2:aB, 7dr2:bB, 7dr2:cB, 7dr2:dB
44 7dwq:B 659 749 0.3987 0.4507 0.3965 6.60e-170 7coy:aB, 7coy:bB, 7coy:cB
45 8jw0:b 617 709 0.2980 0.3598 0.3131 1.10e-96
46 8jjr:b 659 715 0.3047 0.3445 0.3175 3.14e-92
47 8jze:b 663 717 0.3047 0.3424 0.3166 6.26e-92 8jzf:b
48 7zq9:B2 180 192 0.0899 0.3722 0.3490 6.32e-17
49 5v8k:A 600 282 0.0966 0.1200 0.2553 7.15e-14
50 6m32:A 628 81 0.0349 0.0414 0.3210 0.002 6m32:a
51 8gwa:A 667 81 0.0349 0.0390 0.3210 0.002 8gwa:a, 7uea:A, 7uea:a, 7ueb:A, 7ueb:a, 7z6q:A, 7z6q:a
52 7vzg:a 858 120 0.0389 0.0338 0.2417 0.25 7vzg:A, 7vzr:A, 7vzr:a
53 7xg0:D 331 95 0.0322 0.0725 0.2526 1.8 7xfz:C, 7xg0:C, 7xg0:E, 7xg0:F, 7xg1:C, 7xg1:D, 7xg1:E, 7xg2:C, 7xg2:D, 7xg2:E, 7xg2:F, 7xg3:C, 7xg3:D, 7xg3:E, 7xg3:F, 7xg4:C, 7xg4:D, 7xg4:E, 7xg4:F
54 2mnj:B 88 48 0.0228 0.1932 0.3542 2.9
55 1jqg:A 409 60 0.0255 0.0465 0.3167 4.5
56 3bn1:A 368 43 0.0242 0.0489 0.4186 9.5 3bn1:B, 3dr4:A, 3dr4:B, 3dr4:C, 3dr4:D, 3dr7:A, 3dr7:B, 3dr7:C, 3dr7:D

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218