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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
PTPHVVLVPFPGQGHVAPLMQLARLLHARGARVTFVYTQYNYRRLLRAKGEAAVRPPATSSARFRIEVIDDGLSLSVPQN
DVGGLVDSLRKNCLHPFRALLRRLGQEVEGQDAPPVTCVVGDVVMTFAAAAAREAGIPEVQFFTASACGLLGYLHYGELV
ERGLVPFRDASLLADDDYLDTPLEWVPGMSHMRLRDMPTFCRTTDPDDVMVSATLQQMESAAGSKALILNTLYELEKDVV
DALAAFFPPIYTVGPLAEVIASSAMDISIWQEDTRCLSWLDGKPAGSVVYVNFGSMAVMTAAQAREFALGLASCGSPFLW
VKRPDVVEGEEVLLPEALLDEVARGRGLVVPWCPQAAVLKHAAVGLFVSHCGWNSLLEATAAGQPVLAWPCHGEQTTNCR
QLCEVWGNGAQLPREVESGAVARLVREMMVGDLGKEKRAKAAEWKAAAEAAARKGGASWRNVERVVNDLLLVGG

The query sequence (length=474) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 7zer:A 474 474 1.0000 1.0000 1.0000 0.0 7zf0:A
2 8inh:B 454 475 0.3228 0.3370 0.3221 1.68e-70 8inh:A
3 8wvd:A 450 478 0.3122 0.3289 0.3096 7.83e-65 6l8z:A
4 5u6n:B 448 483 0.2996 0.3170 0.2940 1.63e-64 5u6m:A, 5u6m:B, 5u6n:A, 5u6s:A, 5u6s:B, 5v2j:A, 5v2j:B, 5v2k:A, 5v2k:B
5 8i90:A 440 477 0.2911 0.3136 0.2893 1.11e-59 8i90:B, 8i94:A, 8i94:B
6 8wrk:A 434 475 0.2679 0.2926 0.2674 1.57e-57 8in7:A, 8ina:A, 8ind:A, 8inj:A, 8ino:A, 8inv:A, 8wrj:A
7 2vg8:A 465 493 0.3481 0.3548 0.3347 4.98e-57 2vce:A, 2vch:A
8 8w7y:A 474 478 0.3059 0.3059 0.3033 2.69e-56
9 8ita:A 429 465 0.3333 0.3683 0.3398 1.63e-55 8inp:A
10 6jem:A 440 474 0.3059 0.3295 0.3059 1.97e-54 6jem:B, 6jem:C, 6jen:A, 6jen:B, 6jen:C
11 7w11:A 435 474 0.2700 0.2943 0.2700 2.56e-53
12 7w0k:A 457 480 0.2743 0.2845 0.2708 1.65e-52 7w0z:A, 7w10:A, 7w1b:A, 7w1h:A
13 6lzy:A 454 490 0.2869 0.2996 0.2776 3.29e-50 6lzx:A, 6lzx:B, 6lzy:B, 7vej:A, 7vej:B, 7vek:A, 7vek:B, 7vel:A, 7vel:B
14 2acv:A 461 480 0.2911 0.2993 0.2875 4.15e-49 2acv:B, 2acw:A, 2acw:B
15 5nlm:B 448 489 0.3291 0.3482 0.3190 1.13e-48
16 6inh:A 450 468 0.2595 0.2733 0.2628 1.61e-48 6inf:A, 6ing:A, 6ini:A, 6kvi:A, 6kvj:A, 6kvk:A, 6kvl:A, 6o86:A, 6o87:A, 6o88:A
17 6su6:A 467 501 0.3354 0.3405 0.3174 4.53e-48 5nlm:A, 6su6:B, 6su7:A
18 7q3s:A 453 491 0.3186 0.3333 0.3075 1.72e-44
19 8chd:A 461 499 0.3017 0.3102 0.2866 4.19e-44 8chd:B
20 8wp5:A 479 497 0.2764 0.2735 0.2636 1.89e-43
21 6jtd:A 477 502 0.3059 0.3040 0.2888 4.49e-43 6jtd:B
22 5tmb:A 451 484 0.2996 0.3149 0.2934 5.56e-43 6bk0:A, 6bk1:A, 6bk2:A, 6bk3:A, 5tmd:A, 5tme:A
23 2c1z:A 439 473 0.2743 0.2961 0.2748 7.53e-42 2c1x:A, 2c9z:A
24 8cgq:A 458 490 0.3228 0.3341 0.3122 2.65e-40 6lf6:A
25 8hoj:A 451 491 0.2869 0.3016 0.2770 3.35e-40 8hoj:B
26 7bv3:A 457 497 0.2911 0.3020 0.2777 4.10e-40
27 7bv3:B 439 491 0.2743 0.2961 0.2648 8.44e-40
28 8w53:B 479 492 0.2637 0.2610 0.2541 1.45e-39 8w53:A
29 6lg1:A 429 410 0.2679 0.2960 0.3098 1.09e-38 6lg1:B
30 8i0d:A 446 475 0.2447 0.2601 0.2442 1.80e-38 8i0e:A
31 6lfz:B 439 489 0.2827 0.3052 0.2740 3.95e-38 6lfz:A
32 4rel:A 446 476 0.2532 0.2691 0.2521 2.36e-37 4rem:A, 4ren:A, 4whm:A
33 8j2t:A 477 518 0.2954 0.2935 0.2703 4.15e-35 8j2s:A, 8j2s:B, 8j2s:C, 8j2s:D, 8j2s:E, 8j2s:F, 8j2s:G, 8j2t:B, 8j2u:A, 8j2u:B, 8j2v:A, 9j9c:A, 9j9c:B, 9j9c:C, 9j9c:D, 9j9c:E, 9j9c:F, 9j9c:G, 9j9k:A, 9j9k:B
34 6llz:A 436 483 0.2764 0.3005 0.2712 4.39e-34 7cyw:A, 6llw:A, 6llw:B, 6llz:B
35 3hbj:A 445 462 0.2426 0.2584 0.2489 3.93e-33 3hbf:A
36 6l5s:A 454 350 0.2321 0.2423 0.3143 7.93e-33 6l5p:A, 6l5q:A, 6l5r:A, 6l7h:A
37 6l5s:A 454 39 0.0338 0.0352 0.4103 0.11 6l5p:A, 6l5q:A, 6l5r:A, 6l7h:A
38 7va8:A 456 493 0.2679 0.2785 0.2576 2.13e-32 7va8:B, 7vaa:A, 7vaa:B
39 6lg0:B 444 300 0.1899 0.2027 0.3000 1.20e-31 6lg0:A, 6lg0:C, 6lg0:D, 6lg0:E, 6lg0:F
40 6lg0:B 444 36 0.0316 0.0338 0.4167 0.042 6lg0:A, 6lg0:C, 6lg0:D, 6lg0:E, 6lg0:F
41 8hjo:B 440 456 0.2574 0.2773 0.2675 5.34e-31 8hjf:A, 8hjf:B, 8hjg:A, 8hjg:B, 8hjh:A, 8hjh:B, 8hjk:A, 8hjl:A, 8hjl:B, 8hjn:A, 8hjn:B, 8hjo:A, 8hjp:A, 8hjp:B, 8j66:A
42 7es1:A 408 435 0.2764 0.3211 0.3011 5.42e-31 7erx:A, 7es0:A, 7es2:A
43 7c2x:A 490 504 0.2553 0.2469 0.2401 5.69e-28
44 6ija:A 415 270 0.1730 0.1976 0.3037 5.34e-21 6ij9:A, 6ij9:B, 6ij9:C, 6ija:B, 6ijd:A, 6ijd:B
45 6ija:A 415 43 0.0380 0.0434 0.4186 0.002 6ij9:A, 6ij9:B, 6ij9:C, 6ija:B, 6ijd:A, 6ijd:B
46 6ij9:D 388 268 0.1582 0.1933 0.2799 1.75e-19
47 6ij9:D 388 43 0.0380 0.0464 0.4186 0.002
48 8sft:B 428 140 0.0844 0.0935 0.2857 5.50e-06 8gkn:A, 8gkn:B, 8sft:A, 8sft:C, 8sft:D, 8sfu:A, 8sfu:B, 8sfw:A, 8sfy:A
49 2iya:A 392 90 0.0591 0.0714 0.3111 5.41e-05 2iya:B
50 2iya:A 392 36 0.0295 0.0357 0.3889 0.27 2iya:B
51 6kqx:A 327 62 0.0549 0.0795 0.4194 2.23e-04
52 6kqx:A 327 51 0.0359 0.0520 0.3333 0.057
53 7vm0:B 406 111 0.0612 0.0714 0.2613 2.50e-04 8h5d:A, 8h5d:B, 7vm0:A
54 7vm0:B 406 45 0.0295 0.0345 0.3111 0.046 8h5d:A, 8h5d:B, 7vm0:A
55 7vlb:A 385 81 0.0654 0.0805 0.3827 5.75e-04
56 7vlb:A 385 51 0.0359 0.0442 0.3333 0.067
57 7vlb:B 353 81 0.0654 0.0878 0.3827 6.19e-04
58 7vlb:B 353 51 0.0359 0.0482 0.3333 0.068
59 3oth:A 395 80 0.0612 0.0734 0.3625 0.006 3otg:A, 3oth:B
60 6j31:B 387 36 0.0359 0.0439 0.4722 0.057 6j31:A, 6j31:C, 6j31:D
61 6j31:B 387 52 0.0380 0.0465 0.3462 0.091 6j31:A, 6j31:C, 6j31:D
62 3rsc:A 397 68 0.0485 0.0579 0.3382 0.15 3iaa:A, 3iaa:B, 3rsc:B
63 7xx4:A 395 109 0.0633 0.0759 0.2752 0.20 2iyf:A, 2iyf:B, 4m83:A, 4m83:B, 7xx4:B
64 7xx4:A 395 32 0.0274 0.0329 0.4062 1.2 2iyf:A, 2iyf:B, 4m83:A, 4m83:B, 7xx4:B
65 7lvy:A 431 47 0.0338 0.0371 0.3404 0.26 7mco:A, 7mco:B
66 3ia7:A 397 35 0.0295 0.0353 0.4000 2.4 3ia7:B
67 3ia7:A 397 87 0.0485 0.0579 0.2644 6.9 3ia7:B
68 7ye1:D 1144 33 0.0253 0.0105 0.3636 3.0 7ye2:D
69 2vpw:A 734 30 0.0316 0.0204 0.5000 4.4 2vpw:E, 2vpx:A, 2vpx:E, 2vpy:A, 2vpy:E, 2vpz:A, 2vpz:E
70 2hf8:A 211 44 0.0274 0.0616 0.2955 6.1 2hf8:B, 2hf9:A, 2hf9:B
71 4bp9:A 710 51 0.0380 0.0254 0.3529 8.2 4bp9:B, 4bp9:C, 4bp9:D, 4bp9:E, 4bp9:F
72 7n61:0X 420 137 0.0738 0.0833 0.2555 9.0 7n61:0Y, 7n61:0Z, 7n61:1A
73 3rb7:A 248 18 0.0232 0.0444 0.6111 9.0 3e9t:A, 3e9t:B, 3ead:A, 3ead:B, 3ead:C, 3ead:D, 3rb5:A, 3rb5:B, 3rb7:B, 3rb7:E, 3rb7:G
74 2chq:A 313 77 0.0443 0.0671 0.2727 9.3 2chg:A, 2chg:B, 2chg:C, 2chg:D, 2chq:B, 2chq:C

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218