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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
PPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGSSLMKKRRNWHRHDYTEIDDGS
KPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVMDVERYVGGDKVI
DVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYCLM
GVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGW
IHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGV
KALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEEN

The query sequence (length=447) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 3kv6:D 448 447 1.0000 0.9978 1.0000 0.0 3kv5:D, 3kv5:A, 3kv6:A, 3kv9:A, 3kva:A, 3u78:A
2 3kv4:A 432 441 0.6309 0.6528 0.6395 0.0 4do0:A, 3k3n:A, 3k3o:A, 2wwu:A
3 8f8y:B 433 443 0.5682 0.5866 0.5734 0.0 8f8y:A, 8f8z:A, 8f8z:B, 3kqi:A, 7m10:A, 3pu3:A, 3pu3:B, 3pu8:B, 3pu8:A, 3pua:A, 3pus:A, 3pus:B
4 7uv9:K 407 311 0.2841 0.3120 0.4084 1.31e-83 4qwn:A, 4qwn:C, 4qx7:A, 4qx7:C, 4qx8:A, 4qx8:C, 4qxb:A, 4qxb:C, 4qxc:A, 4qxc:C, 4qxh:A, 4qxh:C, 4tn7:A, 4tn7:C, 7uva:A, 7uva:D, 2yu1:A, 2yu2:A
5 3n9m:A 503 428 0.3311 0.2942 0.3458 2.41e-80 3n9l:A, 3n9m:C, 3n9n:A, 3n9o:A, 3n9p:A, 3n9q:A, 3puq:A, 3puq:C, 3pur:A, 3pur:C
6 1wep:A 79 65 0.1007 0.5696 0.6923 7.47e-32
7 1wem:A 76 62 0.0694 0.4079 0.5000 1.08e-16 4l7x:A, 2m3h:A
8 5wlf:A 60 57 0.0626 0.4667 0.4912 7.11e-13 5wle:A
9 2f6j:A 168 48 0.0537 0.1429 0.5000 2.54e-12 8ag2:A, 6aze:A, 7dmy:A, 7dn4:A, 7dn4:B, 7dn4:C, 7dn4:D, 7dn4:E, 7dn4:F, 7f5c:A, 7f5d:A, 7f5e:A, 2f6j:B, 2f6j:C, 2f6n:A, 2f6n:B, 8f6g:A, 2fsa:A, 2fsa:B, 2fsa:C, 2fuu:A, 5h6y:A, 7k6r:A, 7k6s:A, 7kdw:A, 7kdw:B, 7kdz:A, 7lp0:A, 7lp0:B, 7lpk:A, 7lpk:B, 7lrk:A, 7lrk:B, 7lro:A, 7lro:B, 6lu5:A, 6lu6:A, 7m2e:A, 8ou2:A, 8ou2:B, 3qzs:A, 3qzs:B, 3qzt:A, 3qzv:A, 5r4g:A, 5r4h:A, 5r4i:A, 5r4j:A, 5r4k:A, 5r4l:A, 5r4m:A, 5r4n:A, 2ri7:A, 7rwn:A, 7rwo:A, 7rwp:A, 7rwq:A, 7vd4:A
10 9c0o:A 63 47 0.0515 0.3651 0.4894 6.34e-12
11 1we9:A 64 51 0.0470 0.3281 0.4118 1.12e-08
12 5z8l:A 204 54 0.0470 0.1029 0.3889 3.02e-08 5z8n:A, 5z8n:B, 5z8n:C
13 5znp:B 186 48 0.0425 0.1022 0.3958 4.40e-08 5znp:A, 5znr:A, 5znr:B
14 5y20:A 52 44 0.0403 0.3462 0.4091 3.56e-07
15 5yc3:A 60 45 0.0403 0.3000 0.4000 4.51e-07 5yc4:A
16 6j2p:A 98 96 0.0671 0.3061 0.3125 3.54e-06 6j2p:B, 6j2p:D, 6j2p:C
17 6wxk:B 51 48 0.0380 0.3333 0.3542 1.06e-05 6wxk:A, 6wxk:C, 6wxk:D, 6wxk:E
18 6mev:A 341 122 0.0783 0.1026 0.2869 4.04e-04 6gdy:A, 6gdy:B, 3ld8:A, 3ldb:A, 6mev:B, 6mev:C, 6mev:D, 6mev:E, 6mev:F, 6mev:G, 6mev:H
19 8br4:A 339 103 0.0716 0.0944 0.3107 7.07e-04 8br4:B, 8br4:C, 8br4:D, 8br4:E, 8br4:F, 8br4:G, 8br4:H, 8br4:I, 8br4:J, 8br4:K, 8br4:L, 8br4:M, 8br4:N, 8br4:O, 8br4:P
20 5nfn:B 318 88 0.0515 0.0723 0.2614 8.32e-04 5nfn:A, 5nfn:C, 5nfn:D, 5nfo:A, 5nfo:B
21 2lv9:A 80 46 0.0380 0.2125 0.3696 0.002 4l58:A
22 5c11:A 52 46 0.0425 0.3654 0.4130 0.003 3gl6:A, 2kgg:A, 2kgi:A
23 3dmt:A 359 110 0.0649 0.0808 0.2636 0.011 3dmt:B, 3dmt:C, 3dmt:D, 3ids:D, 1k3t:C, 1ml3:B, 1ml3:C, 1ml3:D, 1qxs:C, 1qxs:D, 1qxs:A, 1qxs:B, 2x0n:A, 2x0n:B, 2x0n:O, 2x0n:P, 2x0n:Q, 2x0n:R
24 2k16:A 75 45 0.0403 0.2400 0.4000 0.013 5c13:A, 5c13:C, 5c13:E, 5c13:G, 2k17:A, 5wxg:A, 5wxh:C, 5wxh:A, 5xmy:A, 5xmy:C
25 1x4i:A 70 68 0.0515 0.3286 0.3382 0.014 7zmx:A, 7zmx:B
26 5tab:A 53 37 0.0336 0.2830 0.4054 0.014
27 6ldo:A 381 98 0.0716 0.0840 0.3265 0.020 6ldo:B, 6ldo:C, 6ldo:D, 6ldo:E, 6ldo:F, 6le4:A, 6le4:B, 6le4:C, 6le4:D, 6le4:E, 6le4:F
28 1wee:A 72 55 0.0403 0.2500 0.3273 0.021
29 5oqd:C 192 54 0.0313 0.0729 0.2593 0.037 5oqd:B, 5oqd:A, 5oqd:D, 5oqd:E, 5oqd:F
30 5tdr:A 70 48 0.0358 0.2286 0.3333 0.052 5tdw:A
31 3cmc:O 334 130 0.0649 0.0868 0.2231 0.053 3cmc:P, 3cmc:Q, 3cmc:R, 1dbv:O, 1dbv:P, 1dbv:Q, 1dbv:R, 2dbv:O, 2dbv:P, 2dbv:Q, 2dbv:R, 3dbv:O, 3dbv:P, 3dbv:Q, 3dbv:R, 4dbv:O, 4dbv:P, 4dbv:Q, 4dbv:R, 1gd1:O, 1gd1:P, 1gd1:Q, 1gd1:R, 1npt:O, 1npt:P, 1npt:Q, 1npt:R, 1nq5:O, 1nq5:Q, 1nq5:A, 1nq5:C, 1nqa:O, 1nqa:P, 1nqa:Q, 1nqa:R, 1nqo:O, 1nqo:Q, 1nqo:A, 1nqo:C
32 5tbn:A 57 37 0.0336 0.2632 0.4054 0.084
33 5xfr:A 309 60 0.0425 0.0615 0.3167 0.088 5xfr:B
34 3o70:A 55 40 0.0313 0.2545 0.3500 0.093 3o7a:A
35 6ghr:B 342 108 0.0492 0.0643 0.2037 0.095 4boy:A, 4boy:B, 6gfo:A, 6gfo:B, 6gfo:C, 6gfo:D, 6gfp:A, 6gfp:B, 6gfq:B, 6gfq:A, 6gfr:A, 6gfr:B, 6gg7:B, 6gg7:A, 6ghl:A, 6ghl:D, 6ghl:B, 6ghl:C, 6ghr:D, 6ghr:A, 6ghr:C, 6gve:D, 6gve:A, 6gve:E, 6gve:F, 6gve:I, 6gve:K, 6gve:N, 6gve:O, 3zcx:A, 3zcx:B, 3zdf:B, 3zdf:A
36 4qsz:A 686 92 0.0470 0.0306 0.2283 0.15 8j25:A, 8j2p:E, 8j2p:A, 4kyc:A, 4qsz:B, 4qu2:A, 4qu2:B
37 5xfo:A 315 53 0.0358 0.0508 0.3019 0.18 8h43:A, 8h43:B, 8h43:C, 4hcz:A, 4hcz:B, 7lky:B, 7lky:H, 7lky:A, 7lky:C, 7lky:D, 7lky:E, 7lky:F, 7lky:G, 6wat:AA, 6wat:AC, 6wat:BA, 6wat:BC, 6wat:CA, 6wat:CC, 6wat:DA, 6wat:DC, 6wat:EC, 6wat:EA, 6wat:FA, 6wat:FC, 6wat:GA, 6wat:GC, 6wat:HA, 6wat:HC, 6wat:IA, 6wat:IC, 6wat:JA, 6wat:JC, 6wat:KA, 6wat:KC, 6wat:OC, 6wat:LA, 6wat:LC, 6wat:MA, 6wat:MC, 6wat:NA, 6wat:NC, 6wat:OA, 6wav:A, 6wav:C, 6wav:B, 6wav:D, 5xfn:A, 5xfp:B, 5xfp:A, 5xfp:E, 5xfq:A, 5xfq:B
38 3al5:B 311 140 0.0805 0.1158 0.2571 0.18 3al5:D, 3al6:B, 3al6:D
39 3b1j:A 338 105 0.0604 0.0799 0.2571 0.25 3b1j:B, 3b1k:A, 3b1k:H, 3b1k:B, 3b1k:G, 3b20:A, 3b20:B, 3b20:O, 3b20:P, 3b20:Q, 3b20:R, 2d2i:A, 2d2i:B, 2d2i:O, 2d2i:P, 2d2i:Q, 2d2i:R, 2duu:A, 2duu:B, 2duu:O, 2duu:P, 2duu:Q, 2duu:R
40 4o64:A 116 41 0.0291 0.1121 0.3171 0.37 4o64:B, 4o64:C
41 1dss:G 333 103 0.0559 0.0751 0.2427 0.45 1dss:R, 1gpd:G, 1gpd:R, 1ihx:A, 1ihx:B, 1ihx:C, 1ihx:D, 1ihy:A, 1ihy:B, 1ihy:C, 1ihy:D, 1szj:G, 1szj:R
42 1a7k:A 358 113 0.0626 0.0782 0.2478 0.66 1a7k:B, 1a7k:C, 1a7k:D, 1gyp:A, 1gyp:B, 1gyp:C, 1gyp:D, 1gyq:A, 1gyq:B, 1gyq:C, 1gyq:D, 1i32:A, 1i32:B, 1i32:C, 1i32:D, 1i32:E, 1i32:F, 1i33:A, 1i33:B, 1i33:C, 1i33:D, 1i33:E, 1i33:F
43 7yxg:A 313 87 0.0470 0.0671 0.2414 0.71 7yxg:B, 7yxh:A, 7yxh:B, 7yxi:A, 7yxi:B, 7yxj:A, 7yxj:B, 7yxj:C, 7yxj:D, 7yxk:A, 7yxk:B, 7yxl:A, 7yxl:B
44 6jla:C 184 46 0.0313 0.0761 0.3043 1.2
45 7y0i:A 56 48 0.0380 0.3036 0.3542 1.3
46 7q54:C 368 110 0.0582 0.0707 0.2364 1.8 2pkq:O, 2pkq:Q, 2pkq:T, 7q53:O, 7q53:Q, 7q54:Q, 7q54:O, 7q54:A, 7q55:O, 7q55:Q, 7q55:A, 7q55:C, 7q55:E, 7q55:G, 7q55:I, 7q55:K, 7q56:K, 7q56:E, 7q56:I, 7q56:A, 7q56:G, 7q56:C, 7q56:Q, 7q56:O, 7q57:O, 7q57:Q, 7q57:A, 7q57:C, 7q57:G, 7q57:E, 7q57:I, 7q57:K, 7q57:M, 7q57:S
47 2ma5:A 61 52 0.0447 0.3279 0.3846 2.0
48 4yan:A 252 64 0.0403 0.0714 0.2812 2.4 4yan:B, 4yan:C, 4yan:D
49 2m85:A 65 49 0.0336 0.2308 0.3061 2.8
50 1o68:B 262 27 0.0224 0.0382 0.3704 2.9 1o68:A, 1o68:D, 1o68:E
51 3l0d:A 332 149 0.0805 0.1084 0.2416 3.4 3l0d:B
52 1hdg:O 332 101 0.0492 0.0663 0.2178 3.5 1hdg:Q
53 2xb1:C 97 31 0.0246 0.1134 0.3548 3.7 4up0:A, 4up5:A, 2xb1:A
54 6o7g:B 60 26 0.0201 0.1500 0.3462 4.7 8u2y:B
55 4k9d:A 338 105 0.0470 0.0621 0.2000 4.9 4k9d:B, 4k9d:C, 4k9d:D, 4k9d:E, 4k9d:F, 4k9d:G, 4k9d:H
56 3doc:A 335 110 0.0515 0.0687 0.2091 5.6 3doc:B, 3doc:C, 3doc:D
57 2qic:A 51 50 0.0380 0.3333 0.3400 5.7
58 5m6d:A 346 49 0.0336 0.0434 0.3061 5.8 6fzh:A, 6fzh:B, 6ite:P, 6ite:Q, 6ite:R, 6ite:O
59 5uwy:A 306 69 0.0537 0.0784 0.3478 6.2
60 7t92:C 317 58 0.0447 0.0631 0.3448 6.9
61 3gnq:C 335 107 0.0559 0.0746 0.2336 7.0 3gnq:B, 3gnq:D, 3gnq:E, 3gnq:F, 3gnq:G, 3gnq:H
62 7mqa:LZ 162 52 0.0336 0.0926 0.2885 7.1
63 2gmh:A 581 159 0.0850 0.0654 0.2390 7.9 2gmh:B, 2gmj:A, 2gmj:B
64 3kex:A 292 84 0.0492 0.0753 0.2619 9.1 3kex:B, 3lmg:A, 3lmg:B, 6op9:A, 4riw:A, 4riw:C, 4rix:A, 4rix:C, 4riy:A, 4riy:C
65 1weu:A 91 59 0.0447 0.2198 0.3390 9.5 3c6w:A, 3c6w:C, 2k1j:A, 2m1r:A, 2pnx:A, 2pnx:C, 2vnf:A, 2vnf:C, 1wen:A

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218