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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
PMEDIEEILITEEQLKAKVKELGEMITRDYEGKDLVLIGVLKGAIMFMSGLSRAIDLPLSIDFLAVSSYGSSTKSSGIVK
IIKDHDIDIEGKDVLIVEDIIDSGLTLAYLRETLLGRKPRSLKICTILDKPERREADVKVDYCGFKIPDKFVVGYGLDYA
EKYRNLPFIGVLKPELY

The query sequence (length=177) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2geb:A 184 177 0.9944 0.9565 0.9944 1.59e-123 1r3u:A, 1r3u:B, 1yfz:A, 1yfz:B
2 3kb8:A 201 175 0.5819 0.5124 0.5886 2.70e-69 6d9r:A, 6d9r:B, 6d9s:A, 6d9s:B, 3h83:A, 3h83:B, 3kb8:B
3 4qyi:B 171 167 0.5254 0.5439 0.5569 1.39e-67 4qyi:A, 4qyi:C, 4qyi:D, 4qyi:E
4 4pfq:C 184 177 0.5254 0.5054 0.5254 8.82e-65 4pfq:A, 4pfq:B, 4pfq:D, 4pfq:E, 4pfq:F, 4pfq:G, 4pfq:H
5 5knx:B 176 171 0.5311 0.5341 0.5497 1.03e-63 1g9s:A, 1g9s:B, 1g9t:A, 1g9t:B, 1grv:B, 1grv:A, 1j7j:A, 1j7j:B, 5knr:A, 5knr:B, 5kns:A, 5kns:B, 5knt:A, 5knt:B, 5knu:A, 5knu:B, 5knv:A, 5knv:B, 5knx:A
6 5kny:B 187 180 0.5706 0.5401 0.5611 1.55e-60 5knp:A, 5knp:B, 5knp:C, 5knp:D, 5knq:A, 5knq:B, 5knq:C, 5knq:D, 5kny:A, 5kny:C, 5kny:D, 4rht:A, 4rht:B, 4rht:C, 4rht:D, 4rhu:A, 4rhu:B, 4rhu:C, 4rhu:D, 4rhu:E, 4rhu:F, 4rhx:A, 4rhx:B, 4rhx:C, 4rhx:D, 4rhy:A, 4rhy:B, 4rhy:C, 4rhy:D
7 3acc:A 166 168 0.4633 0.4940 0.4881 2.79e-51 3acd:A
8 1hgx:A 164 173 0.4181 0.4512 0.4277 9.34e-45
9 1p17:B 204 185 0.4689 0.4069 0.4486 1.43e-44 1i0i:A, 1i0i:B, 1i0l:A, 1i0l:B, 1i13:A, 1i13:B, 1i14:A, 1i14:B, 1p17:A, 1p17:C, 1p17:D, 1p18:A, 1p18:B, 1p19:A, 1p19:B, 1p19:C, 1p19:D, 1tc1:A, 1tc1:B, 1tc2:A, 1tc2:B
10 6igs:B 167 167 0.4124 0.4371 0.4371 9.55e-43 6igs:A, 6igs:C, 6igs:D
11 7cmj:A 184 184 0.4294 0.4130 0.4130 1.07e-41 1pzm:A, 1pzm:B
12 1bzy:A 214 180 0.3616 0.2991 0.3556 2.17e-29 6bnj:A, 6bnj:B, 6bnj:C, 6bnj:D, 5brn:A, 5brn:C, 5brn:D, 1bzy:B, 1bzy:C, 1bzy:D, 1d6n:A, 1d6n:B, 3gep:A, 3gep:B, 3ggc:A, 3ggc:B, 3ggj:A, 3ggj:B, 5hia:A, 5hia:B, 5hia:C, 5hia:D, 1hmp:A, 1hmp:B, 4ijq:A, 4ijq:B, 4ijq:C, 4ijq:D, 4rab:A, 4rab:B, 4rab:C, 4rab:D, 4rac:A, 4rac:B, 4rac:C, 4rac:D, 4rad:A, 4rad:B, 4rad:C, 4rad:D, 4rad:E, 4rad:F, 4rad:G, 4rad:H, 4ran:A, 4ran:B, 4ran:C, 4ran:D, 4rao:A, 4rao:B, 4rao:C, 4rao:D, 4raq:A, 4raq:B, 4raq:C, 4raq:D, 7san:A, 7san:B, 7san:C, 7san:D, 8tpv:A, 8tpv:B, 8tpv:C, 8tpv:D, 5w8v:A, 5w8v:B, 5w8v:C, 5w8v:D
13 8fx3:B 223 196 0.3446 0.2735 0.3112 5.60e-26 8fwy:A, 8fwy:B, 8fwz:A, 8fwz:B, 8fx0:A, 8fx0:B, 8fx1:A, 8fx1:B, 8fx2:A, 8fx2:B, 8fx3:A
14 6mxc:C 220 195 0.3390 0.2727 0.3077 2.03e-25 6aqo:A, 6aqo:B, 6aqo:C, 6aqo:D, 6aqo:E, 6aqo:F, 6ar9:A, 6ar9:B, 6ar9:C, 6ar9:D, 6ar9:E, 6ar9:F, 6mxb:A, 6mxb:B, 6mxb:C, 6mxb:D, 6mxb:E, 6mxb:F, 6mxc:A, 6mxc:B, 6mxc:D, 6mxc:E, 6mxc:F, 6mxd:A, 6mxd:B, 6mxd:C, 6mxd:D, 7scr:A, 7scr:C, 7scr:B, 7scr:D, 7scr:E, 7scr:F
15 6aps:A 185 180 0.3164 0.3027 0.3111 1.05e-23 6aps:B, 6apt:A, 6apt:B, 6apu:A, 6apu:B, 6apv:A, 6apv:B, 6apv:C, 6apv:D, 5jsq:A, 5jsq:B, 5jv5:A, 5jv5:B, 5k51:A, 5k51:B, 5k51:C, 5k51:D, 5kam:A, 5kam:C, 5kap:A, 5kap:B, 6mxg:A, 6mxg:B, 7sb7:A, 7sb7:B, 8tr1:A, 8tr1:B, 8tr1:C, 8tr1:D, 8ts4:A, 8ts4:B
16 5brn:B 194 170 0.3220 0.2938 0.3353 1.62e-23 5bsk:A, 5bsk:B, 5bsk:C, 5bsk:D, 4kn6:A, 8tpy:A, 8tpy:B, 8tpy:C, 8tpy:D
17 2jbh:B 213 180 0.3390 0.2817 0.3333 3.31e-22 2jbh:A
18 2vfa:B 205 181 0.3107 0.2683 0.3039 4.94e-21 2vfa:A
19 1fsg:A 233 181 0.3220 0.2446 0.3149 7.32e-20 1dbr:A, 1dbr:B, 1dbr:D, 1fsg:C, 1qk3:A, 1qk3:B, 1qk3:C, 1qk3:D, 1qk4:A, 1qk4:B, 1qk4:C, 1qk4:D, 1qk5:A, 1qk5:B
20 5esw:A 190 169 0.2542 0.2368 0.2663 1.28e-19 5esx:A, 5esx:B
21 5ipf:A 201 183 0.3164 0.2786 0.3060 1.70e-19 5ipf:B, 5ipf:C, 5ipf:D
22 3ozf:B 234 183 0.3107 0.2350 0.3005 2.00e-18 1cjb:A, 1cjb:B, 1cjb:C, 1cjb:D, 3ozf:A, 3ozf:C, 3ozf:D, 3ozg:A, 3ozg:B, 3ozg:C, 3ozg:D, 7tux:A, 7tux:B, 7tux:C, 7tux:D
23 6bo7:A 220 180 0.3107 0.2500 0.3056 2.94e-18 6bo7:B, 6bo7:C, 6bo7:D, 6bo7:E, 6bo7:F, 6bo7:G, 6bo7:H, 6bo7:I, 6bo7:J, 6bo7:K, 6bo7:L
24 4p86:A 177 153 0.2203 0.2203 0.2549 9.38e-06 4p86:B, 4p86:C, 4p86:D
25 1a95:B 150 131 0.1808 0.2133 0.2443 0.005 1a95:C, 1a96:B, 1a96:C, 1a97:B, 1a97:C, 4jit:B, 4jit:C
26 5xtk:A 150 129 0.1751 0.2067 0.2403 0.009
27 4zfn:B 177 130 0.1808 0.1808 0.2462 0.052 5bqp:A, 5bqp:B, 5bqp:C, 5bqp:D, 4z1o:A, 4z1o:B, 4zfn:A
28 4b4u:B 286 31 0.0734 0.0455 0.4194 0.35 4b4u:A, 4b4v:A, 4b4v:B, 4b4w:A, 4b4w:B
29 1uqw:A 487 54 0.1017 0.0370 0.3333 0.48 1uqw:B
30 4twb:A 278 25 0.0678 0.0432 0.4800 0.67 4twb:B, 4twb:C, 4twb:D, 4twb:E, 4twb:F
31 4trb:B 209 82 0.1356 0.1148 0.2927 0.74 4trc:A, 4trc:B, 4ts5:A, 4ts5:B, 4ts7:A, 4ts7:B
32 3mbi:A 287 23 0.0678 0.0418 0.5217 1.5 3lpn:A, 3lpn:B, 3lrt:A, 3lrt:B, 3mbi:C, 3mbi:B, 3mbi:D, 3nag:A, 3nag:B
33 6asv:C 311 27 0.0678 0.0386 0.4444 1.8 6asv:A, 6asv:B, 4s2u:A, 7xmu:A, 7xmu:F, 7xmu:C, 7xmu:D, 7xmu:B, 7xmu:E, 7xmv:A, 7xmv:F, 7xmv:C, 7xmv:E, 7xmv:B, 7xmv:D, 7xn3:A, 7xn3:E, 7xn3:C, 7xn3:B, 7xn3:D, 7xn3:F
34 4jls:B 135 131 0.1582 0.2074 0.2137 1.9 4jls:A, 4jls:C, 4jls:D, 4jls:E, 4jls:H, 4jls:I, 4jls:J
35 7kl6:A 147 84 0.1299 0.1565 0.2738 2.0
36 3j3v:S 112 34 0.0508 0.0804 0.2647 2.6 7aqc:S, 7aqd:S, 7as8:W, 7as9:W, 8buu:S, 6ha1:S, 6ha8:S, 6htq:S, 3j3w:S, 3j9w:BV, 5njt:l, 7o5b:r, 7ope:W, 6ppf:S, 6ppk:S, 6pvk:S, 8qcq:S, 7qgu:S, 7qh4:S, 8qpp:r, 7qv1:S, 7qv2:S, 7qv3:S, 8r55:r, 8s1p:S, 8s1u:S, 7s9u:S, 7sae:S, 6tnn:l, 6tpq:l
37 3tgw:B 441 80 0.1243 0.0499 0.2750 2.6 3b2q:A, 3b2q:B, 3dsr:A, 3dsr:B, 3eiu:A, 3eiu:B, 3tiv:B
38 6deb:B 284 65 0.1130 0.0704 0.3077 2.7 3p2o:A, 3p2o:B
39 7qep:C1 141 57 0.1017 0.1277 0.3158 2.8
40 4ynn:A 400 121 0.1864 0.0825 0.2727 2.8 4ynn:B, 4ynn:C, 4ynn:D, 4ynn:E, 4ynn:F, 4ynn:G, 4ynn:H
41 6v6y:A 277 38 0.0734 0.0469 0.3421 3.6
42 1m1b:A 291 123 0.1751 0.1065 0.2520 4.5 1m1b:B, 1pym:A, 1pym:B
43 8fpj:A 1345 93 0.1186 0.0156 0.2258 4.5
44 8uu5:U 112 62 0.0904 0.1429 0.2581 5.1 8a57:V, 8a5i:V, 8a63:V, 7nhn:V, 8uu4:U, 8uu6:U, 8uu7:U, 8uu8:U, 8uu9:U, 8uua:U
45 4js1:A 318 121 0.1751 0.0975 0.2562 5.3 4js2:A, 6qvt:A, 6qvt:B
46 8k21:E 295 42 0.0791 0.0475 0.3333 6.8 8k21:d, 8k21:e, 8k21:D, 8k22:E, 8k22:d, 8k22:e, 8k22:D, 8k23:E, 8k23:d, 8k23:e, 8k23:D, 8k24:d, 8k24:e, 8k24:E, 8k24:D, 8k25:d
47 4zcf:C 627 49 0.0791 0.0223 0.2857 6.9
48 5vog:A 176 168 0.1864 0.1875 0.1964 7.2
49 8usu:A 316 77 0.1356 0.0759 0.3117 9.1 8usu:B
50 2ct2:A 88 64 0.1186 0.2386 0.3281 9.2 5fey:A, 5fey:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218