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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
PLRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSNLNLDARNLLAYKQTE
DLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRS
TPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSI
SLCVYDELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTSTIEQELMQNKVDHNEV
EEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKS
QILQYVHKITPRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTIS
IAKAGIITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPDD
VLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDDSEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQ
EAVRLIRSAIKDYATDPKTGKIDMNLVQTG

The query sequence (length=670) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 5v8f:4 741 674 0.9836 0.8893 0.9777 0.0 5bk4:C, 5bk4:4, 6eyc:4, 6f0l:C, 3ja8:4, 7p30:4, 7p30:C, 7p5z:C, 7p5z:4, 7pt6:4, 7pt6:D, 7pt7:4, 7pt7:D, 6rqc:4, 7v3u:4, 7v3u:D, 7v3v:4, 7v3v:D, 7w8g:4, 7w8g:D
2 8kg8:4 697 666 0.9358 0.8996 0.9414 0.0 8b9a:4, 8b9b:4, 8b9c:4, 8kg6:4, 8p5e:4, 8p62:4, 8p63:4, 7pmk:4, 7pmn:4, 7qhs:4, 6sko:4, 8w7m:4, 7z13:4, 7z13:c
3 6skl:4 679 670 0.9015 0.8895 0.9015 0.0 8kg9:4, 8xgc:4
4 7w1y:4 653 663 0.4970 0.5100 0.5023 0.0 7w1y:C, 6xtx:4, 6xty:4
5 8b9d:4 677 670 0.4866 0.4815 0.4866 0.0 7pfo:4, 7plo:4
6 6rax:4 626 657 0.4761 0.5096 0.4855 0.0 6raw:4, 6ray:4, 6raz:4
7 8ouw:4 619 657 0.4418 0.4782 0.4505 0.0
8 4r7y:A 591 649 0.3612 0.4095 0.3729 9.04e-130 4r7y:B, 4r7z:A, 4r7z:B, 4r7z:C, 4r7z:D, 4r7z:E, 4r7z:F, 4r7z:G, 4r7z:H, 4r7z:I, 4r7z:P, 4r7z:J, 4r7z:K, 4r7z:L, 4r7z:M, 4r7z:N, 4r7z:O
9 8x7u:D 654 601 0.3463 0.3547 0.3860 3.67e-129 8x7u:E, 8x7u:C, 8x7u:B, 8x7u:F, 8x7u:A
10 4fdg:B 592 639 0.3299 0.3733 0.3459 6.84e-118 8eaf:A, 8eaf:B, 8eaf:C, 8eaf:D, 8eaf:E, 8eaf:F, 8eag:B, 8eag:C, 8eag:D, 8eag:E, 8eag:F, 8eag:A, 8eah:A, 8eah:B, 8eah:C, 8eah:D, 8eah:E, 8eah:F, 8eai:B, 8eai:C, 8eai:D, 8eai:E, 8eai:F, 8eai:A, 8eaj:A, 8eaj:B, 8eaj:C, 8eaj:D, 8eaj:E, 8eaj:F, 8eak:B, 8eak:C, 8eak:D, 8eak:E, 8eak:A, 8eak:F, 8eal:A, 8eal:B, 8eal:C, 8eal:D, 8eal:E, 8eal:F, 8eam:B, 8eam:C, 8eam:D, 8eam:E, 8eam:A, 8eam:F, 4fdg:A, 4fdg:C, 4fdg:D, 4fdg:E, 6mii:A, 6mii:B, 6mii:C, 6mii:D, 6mii:E, 6mii:F, 2vl6:A, 2vl6:B, 2vl6:C, 6wnz:B, 6wnz:A
11 8ouw:7 632 519 0.2955 0.3133 0.3815 1.65e-111
12 7w1y:2 706 581 0.3090 0.2932 0.3563 4.64e-111 7pfo:2, 7plo:2, 8q6o:A, 8q6o:2, 8q6p:2, 7w1y:A, 6xtx:2, 6xty:2
13 5v8f:6 692 542 0.3075 0.2977 0.3801 2.88e-110 8b9a:6, 8b9b:6, 8b9c:6, 6eyc:6, 3ja8:6, 8kg6:6, 8kg8:6, 8kg9:6, 7p30:6, 7p30:E, 7p5z:6, 7p5z:E, 8p5e:6, 8p62:6, 8p63:6, 7pmk:6, 7pmn:6, 6ptn:m, 6ptn:6, 6pto:l, 6pto:6, 7pt6:6, 7pt6:F, 7pt7:6, 7pt7:F, 6rqc:6, 6skl:6, 6sko:6, 6u0m:6, 5u8s:6, 8w7m:6, 8xgc:6
14 7v3u:6 646 559 0.3134 0.3251 0.3757 1.01e-109 7qhs:6, 7v3u:F, 7v3v:6, 7v3v:F, 7w8g:6, 7w8g:F, 7z13:6, 7z13:e
15 7w1y:F 643 515 0.3179 0.3313 0.4136 1.78e-109 7w1y:7
16 8p5e:5 695 671 0.3269 0.3151 0.3264 3.24e-109 6eyc:5, 6f0l:D, 6f0l:5, 3ja8:5, 8kg6:5, 8kg8:5, 8kg9:5, 7p30:5, 7p30:D, 7p5z:5, 7p5z:D, 8p62:5, 8p63:5, 7pmk:5, 6ptn:l, 6ptn:5, 6pto:k, 6pto:5, 7pt6:5, 7pt6:E, 7pt7:5, 7pt7:E, 7qhs:5, 6rqc:5, 6skl:5, 6u0m:5, 5u8s:5, 5u8t:5, 7v3u:5, 7v3u:E, 7v3v:5, 7v3v:E, 7w8g:5, 7w8g:E, 8xgc:5, 7z13:5, 7z13:d
17 5u8t:6 661 549 0.3045 0.3086 0.3716 2.72e-108 6wgi:6
18 6raw:6 601 636 0.3343 0.3727 0.3522 6.09e-108 6raz:6
19 7v3u:7 699 526 0.3209 0.3076 0.4087 2.59e-107 5bk4:F, 5bk4:7, 6eyc:7, 3ja8:7, 7p30:7, 7p30:F, 7p5z:7, 7p5z:F, 7v3u:G, 7v3v:7, 7v3v:G, 7w8g:7, 7w8g:G
20 6rax:6 628 653 0.3358 0.3583 0.3446 2.73e-107 6ray:6
21 5v8f:7 725 525 0.3224 0.2979 0.4114 3.05e-107 8b9a:7, 8b9b:7, 8b9c:7, 3jc6:7, 3jc7:7, 8kg6:7, 8kg8:7, 8p5e:7, 8p62:7, 8p63:7, 7pt6:7, 7pt6:G, 7pt7:7, 7pt7:G, 7qhs:7, 6rqc:7, 6sko:7, 8w7m:7, 7z13:7, 7z13:f
22 6xtx:7 598 515 0.3134 0.3512 0.4078 3.76e-107 6xty:7
23 6rax:2 605 634 0.3075 0.3405 0.3249 2.84e-106 6raw:2, 6ray:2
24 7pt6:2 629 631 0.3209 0.3418 0.3407 7.47e-106 5bk4:2, 5bk4:A, 6eyc:2, 6f0l:A, 6f0l:2, 3ja8:2, 7p30:2, 7p30:A, 7p5z:2, 7p5z:A, 7pt6:B, 7pt7:2, 7pt7:B, 6rqc:2, 6sko:2, 5u8s:2, 7v3u:2, 7v3u:B, 7v3v:2, 7v3v:B, 5v8f:2, 8w7m:2, 7w8g:2, 7w8g:B
25 8b9d:2 576 443 0.2672 0.3108 0.4041 3.20e-105
26 5bk4:D 661 682 0.3209 0.3253 0.3152 1.20e-104 5bk4:5
27 7pmn:5 660 659 0.3119 0.3167 0.3171 1.51e-104
28 7plo:7 607 515 0.3030 0.3344 0.3942 7.91e-104 7pfo:7
29 6xtx:6 679 518 0.2896 0.2857 0.3745 5.01e-102 8b9d:6, 7pfo:6, 7plo:6, 6xty:6
30 5u8t:2 583 625 0.3134 0.3602 0.3360 2.38e-101
31 8xgc:2 778 650 0.3164 0.2725 0.3262 4.98e-101 8kg6:2, 8kg8:2, 8kg9:2, 8p5e:2, 8p62:2, 8p63:2, 7pmk:2, 7pmn:2, 6ptn:i, 6ptn:2, 6pto:h, 6pto:2, 7qhs:2, 6skl:2, 6u0m:2, 7z13:2, 7z13:a
32 7w1y:5 710 631 0.3179 0.3000 0.3376 1.45e-100 7plo:5, 7w1y:D
33 8kg9:7 636 519 0.3030 0.3192 0.3911 1.50e-100 7pmk:7, 7pmn:7, 6skl:7, 8xgc:7
34 7w1y:6 716 540 0.2940 0.2751 0.3648 3.76e-100 7w1y:E
35 6rax:5 620 648 0.3239 0.3500 0.3349 4.50e-99 6ray:5, 6raz:5
36 8w7m:3 619 527 0.3000 0.3247 0.3814 8.72e-99 8b9a:3, 8b9b:3, 8b9c:3, 7pmk:3, 6skl:3, 8xgc:3
37 7pfo:5 605 628 0.3060 0.3388 0.3264 4.10e-98 8b9d:5
38 8ouw:2 701 650 0.3119 0.2981 0.3215 1.97e-97
39 7pt7:C 633 548 0.2985 0.3160 0.3650 1.56e-96
40 8p5e:3 649 555 0.2985 0.3082 0.3604 1.70e-96 8kg6:3, 8kg8:3, 8kg9:3, 8p62:3, 8p63:3, 7pt6:3, 7pt6:C, 7pt7:3, 7qhs:3, 7v3u:3, 7v3u:C, 7v3v:3, 7v3v:C, 7w8g:3, 7w8g:C, 7z13:3, 7z13:b
41 6raz:7 601 562 0.3149 0.3511 0.3754 2.73e-96 6ray:7
42 6hv9:3 558 519 0.2910 0.3495 0.3757 2.78e-96
43 6wgi:3 637 517 0.2851 0.2998 0.3694 6.05e-96
44 6xtx:3 608 634 0.3179 0.3503 0.3360 9.72e-96
45 6rax:7 632 528 0.3090 0.3275 0.3920 1.06e-95 6raw:7
46 8b9d:7 576 511 0.2910 0.3385 0.3816 1.27e-95
47 6hv9:5 628 655 0.3104 0.3312 0.3176 5.01e-95
48 6raw:5 576 638 0.3194 0.3715 0.3354 1.87e-94
49 5v8f:3 654 517 0.2851 0.2920 0.3694 2.10e-94 5bk4:B, 5bk4:3, 6eyc:3, 6f0l:3, 6f0l:B, 3ja8:3, 7p30:3, 7p30:B, 7p5z:3, 7p5z:B, 6ptn:j, 6ptn:3, 6pto:i, 6pto:3, 6rqc:3, 6sko:3, 6u0m:3, 5u8s:3, 5u8t:3
50 8b9d:3 569 629 0.3164 0.3726 0.3370 9.96e-94
51 6raz:2 559 633 0.2985 0.3578 0.3160 1.02e-92
52 7plo:3 628 654 0.3179 0.3392 0.3257 4.18e-92 7pfo:3
53 8ouw:6 707 647 0.3075 0.2914 0.3184 1.84e-91
54 8ouw:3 619 461 0.2567 0.2779 0.3731 3.11e-91
55 7w1y:B 651 664 0.3194 0.3287 0.3223 3.70e-91 7w1y:3
56 8q6p:5 321 334 0.2209 0.4611 0.4431 1.18e-88
57 8b9a:5 533 638 0.2851 0.3583 0.2994 1.76e-87 8b9b:5, 8b9c:5, 6sko:5
58 6ray:3 600 455 0.2507 0.2800 0.3692 2.30e-87 6raw:3, 6raz:3
59 6xtx:5 577 621 0.2940 0.3414 0.3172 2.61e-87 6xty:5
60 8q6p:3 370 356 0.2254 0.4081 0.4242 4.62e-87
61 6rax:3 625 473 0.2507 0.2688 0.3552 1.48e-84
62 8q6p:6 395 330 0.2119 0.3595 0.4303 2.98e-84
63 6hv9:2 549 628 0.3000 0.3661 0.3201 1.62e-82
64 8ouw:5 541 661 0.3045 0.3771 0.3086 9.13e-78
65 8w7m:5 529 644 0.2731 0.3459 0.2842 3.32e-76
66 8s91:A 602 592 0.2701 0.3007 0.3057 6.86e-75 7dp3:A, 8s91:B, 8s91:C, 8s94:A, 8s94:C, 8s94:B
67 8s91:D 621 584 0.2791 0.3011 0.3202 1.36e-74 7dpd:A, 7dpd:B, 8s91:E, 8s91:F, 8s94:D, 8s94:F, 8s94:E
68 8b9a:2 568 636 0.2746 0.3239 0.2893 2.39e-74 8b9b:2, 8b9c:2
69 8q6p:7 298 329 0.2239 0.5034 0.4559 1.11e-73
70 8q6o:C 258 289 0.1821 0.4729 0.4221 3.83e-73 8q6o:4
71 7wi7:A 565 581 0.2612 0.3097 0.3012 9.98e-71
72 7wi7:B 566 588 0.2701 0.3198 0.3078 4.07e-67
73 1ltl:E 242 209 0.0851 0.2355 0.2727 2.47e-16 1ltl:A, 1ltl:B, 1ltl:C, 1ltl:D, 1ltl:F
74 4pof:A 255 216 0.0851 0.2235 0.2639 2.98e-16 5iy0:A, 5iy0:B, 5iy0:C, 5iy0:D, 5iy0:E, 5iy0:F, 4pof:B, 4pof:C, 4pof:D, 4pof:E, 4pof:F, 4pog:A, 4pog:E, 4pog:F, 4pog:K, 4pog:L, 4pog:G, 4pog:H, 4pog:I, 4pog:J, 4pog:B, 4pog:C, 4pog:D, 4ywl:A, 4ywl:B, 4ywl:C, 4ywl:D, 4ywl:E, 4ywl:F, 4ywl:G, 4ywl:H, 4ywl:I, 4ywl:J, 4ywm:A, 4ywm:B, 4ywm:C, 4ywm:D, 4ywm:E, 4ywm:F, 4ywm:G, 4ywm:H, 4ywm:I, 4ywm:J
75 8q6o:E 249 130 0.0597 0.1606 0.3077 2.99e-13 8q6o:6
76 8q6o:D 256 259 0.0896 0.2344 0.2317 7.52e-10 8q6o:5
77 4me3:A 246 185 0.0701 0.1911 0.2541 4.59e-09
78 8q6o:F 275 129 0.0582 0.1418 0.3023 4.86e-09 8q6o:7
79 7vno:A 452 125 0.0433 0.0642 0.2320 0.24 7vno:B, 7vnt:A, 7vnt:B, 7vo1:A, 7vo1:B
80 6k6s:A 443 55 0.0299 0.0451 0.3636 1.2 6k6s:B
81 5n1t:A 393 54 0.0209 0.0356 0.2593 1.3
82 8osg:B 323 90 0.0343 0.0712 0.2556 1.4 8osf:A, 8osf:B, 8osf:C, 8osf:D, 8osf:E, 8osg:C, 8osg:D, 8osg:E
83 6vfx:E 341 59 0.0269 0.0528 0.3051 2.0 6vfs:E, 6vfs:C, 6vfs:D, 6vfx:C, 6vfx:B, 6vfx:D, 6vfx:A
84 1ny5:B 385 125 0.0463 0.0805 0.2480 2.7 4bs1:A, 4bs1:B, 4bt0:A, 4bt0:B, 4bt1:A, 4bt1:B, 4ly6:A, 4ly6:B, 4ly6:C, 4ly6:D, 4ly6:E, 4ly6:G, 4ly6:H, 4ly6:I, 4ly6:J, 4ly6:K, 4ly6:L, 4ly6:M, 4ly6:N, 4ly6:O, 4ly6:P, 4ly6:Q, 4ly6:R, 4ly6:S, 4ly6:T, 4ly6:U, 4ly6:V, 4ly6:W, 4ly6:X, 4lzz:A, 4lzz:B, 4lzz:C, 4lzz:D, 4lzz:E, 4lzz:F, 4lzz:G, 4lzz:H, 4lzz:I, 4lzz:J, 4lzz:K, 4lzz:L, 4lzz:M, 4lzz:N, 4lzz:O, 4lzz:P, 4lzz:Q, 4lzz:R, 4lzz:S, 4lzz:T, 4lzz:U, 4lzz:V, 4lzz:W, 4lzz:X, 3m0e:A, 3m0e:B, 3m0e:C, 3m0e:D, 3m0e:E, 3m0e:F, 3m0e:G, 1ny5:A, 1ny6:A, 1ny6:B, 1ny6:C, 1ny6:D, 1ny6:E, 1ny6:F, 1ny6:G, 1ny6:H, 1ny6:I, 1ny6:J, 1ny6:K, 1ny6:L, 1ny6:M, 1ny6:N, 1zy2:A
85 3ug7:A 317 70 0.0284 0.0599 0.2714 3.0 3ug6:A, 3ug6:B, 3ug6:C, 3ug6:D, 3ug7:B, 3ug7:C, 3ug7:D
86 8bxl:B 590 49 0.0254 0.0288 0.3469 3.0 8bxl:C, 8bxl:D, 8bxl:A, 8bxl:F, 8bxl:E
87 6tly:A 99 55 0.0239 0.1616 0.2909 3.8
88 6ylg:t 431 48 0.0239 0.0371 0.3333 4.0 6ylh:t
89 4aie:A 537 77 0.0328 0.0410 0.2857 4.6
90 3zkn:A 375 48 0.0284 0.0507 0.3958 8.4 7d5b:A, 7d5u:A, 2ewy:A, 2ewy:B, 2ewy:C, 2ewy:D, 7f1g:A, 6jsz:A, 7n4n:A, 6uj0:A, 6uj0:B, 6uj1:A, 6uj1:B, 3zki:A, 3zki:B, 3zkn:B, 3zks:A, 3zlq:A, 3zlq:B
91 6or5:A 2058 123 0.0493 0.0160 0.2683 8.9

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218